Metabolism of bile acids, liver diseases and microbiome
Aim of review. To present the modern data on interrelation of bile acid (BA) metabolism, microbiome and liver diseases. Summary. Bile acids are important signaling molecules that regulate lipid and glucose metabolism. Enterohepatic circulation of BA plays the central role in nutrient absorption and...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/224 |
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| _version_ | 1823860291531702272 |
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| author | Yu. V. Yevsyutina V. T. Ivashkin |
| author_facet | Yu. V. Yevsyutina V. T. Ivashkin |
| author_sort | Yu. V. Yevsyutina |
| collection | DOAJ |
| description | Aim of review. To present the modern data on interrelation of bile acid (BA) metabolism, microbiome and liver diseases. Summary. Bile acids are important signaling molecules that regulate lipid and glucose metabolism. Enterohepatic circulation of BA plays the central role in nutrient absorption and metabolic regulation. Data of investigations demonstrate interrelation of BA, intestinal microbiome and liver diseases. In particular, the role of BA metabolism disorders in development of non-alcoholic fatty liver disease is extensively studied. Sequestrants of BA are under study as putative BA and glucose metabolism regulators then draws interest from practical point of view. Conclusion. Bile acids carry out multiple physiological functions. The link between BA metabolism, liver disease and intestinal microbiome is demonstrated by numerous investigations. |
| format | Article |
| id | doaj-art-7d198efff53a4aecbe69b76fb7d62c6b |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-7d198efff53a4aecbe69b76fb7d62c6b2025-02-10T16:14:29ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-0128241010.22416/1382-4376-2018-28-2-4-10224Metabolism of bile acids, liver diseases and microbiomeYu. V. Yevsyutina0V. T. Ivashkin1National Research Center for Preventive MedicineSechenov First Moscow State Medical University (Sechenov University)Aim of review. To present the modern data on interrelation of bile acid (BA) metabolism, microbiome and liver diseases. Summary. Bile acids are important signaling molecules that regulate lipid and glucose metabolism. Enterohepatic circulation of BA plays the central role in nutrient absorption and metabolic regulation. Data of investigations demonstrate interrelation of BA, intestinal microbiome and liver diseases. In particular, the role of BA metabolism disorders in development of non-alcoholic fatty liver disease is extensively studied. Sequestrants of BA are under study as putative BA and glucose metabolism regulators then draws interest from practical point of view. Conclusion. Bile acids carry out multiple physiological functions. The link between BA metabolism, liver disease and intestinal microbiome is demonstrated by numerous investigations.https://www.gastro-j.ru/jour/article/view/224микробиомжелчные кислотынеалкогольная жировая болезнь печенисеквестранты желчных кислотинфекция clostridium difficile |
| spellingShingle | Yu. V. Yevsyutina V. T. Ivashkin Metabolism of bile acids, liver diseases and microbiome Российский журнал гастроэнтерологии, гепатологии, колопроктологии микробиом желчные кислоты неалкогольная жировая болезнь печени секвестранты желчных кислот инфекция clostridium difficile |
| title | Metabolism of bile acids, liver diseases and microbiome |
| title_full | Metabolism of bile acids, liver diseases and microbiome |
| title_fullStr | Metabolism of bile acids, liver diseases and microbiome |
| title_full_unstemmed | Metabolism of bile acids, liver diseases and microbiome |
| title_short | Metabolism of bile acids, liver diseases and microbiome |
| title_sort | metabolism of bile acids liver diseases and microbiome |
| topic | микробиом желчные кислоты неалкогольная жировая болезнь печени секвестранты желчных кислот инфекция clostridium difficile |
| url | https://www.gastro-j.ru/jour/article/view/224 |
| work_keys_str_mv | AT yuvyevsyutina metabolismofbileacidsliverdiseasesandmicrobiome AT vtivashkin metabolismofbileacidsliverdiseasesandmicrobiome |