Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease
Introduction: Essential oil (EO) of eucalyptus has been commonly used as a traditional Chinese medicine to treat illnesses such as influenza, dysentery and eczema, and it is widely used in the pharmaceutical industry. However, its neuroprotective effects have not been fully demonstrated. Given the r...
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Elsevier
2025-03-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142525000132 |
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| author | Aracely Janneth Naranjo-Viteri Matías Jávega Cometto Matías Caverzan Leandro Gabriel Champarini María Paula Zunino Rogelio E. Abburra Claudia B. Hereñú Rosana Crespo |
| author_facet | Aracely Janneth Naranjo-Viteri Matías Jávega Cometto Matías Caverzan Leandro Gabriel Champarini María Paula Zunino Rogelio E. Abburra Claudia B. Hereñú Rosana Crespo |
| author_sort | Aracely Janneth Naranjo-Viteri |
| collection | DOAJ |
| description | Introduction: Essential oil (EO) of eucalyptus has been commonly used as a traditional Chinese medicine to treat illnesses such as influenza, dysentery and eczema, and it is widely used in the pharmaceutical industry. However, its neuroprotective effects have not been fully demonstrated. Given the rising prevalence of the neurodegenerative disorder, Parkinson's disease, in aging populations, this study aims to investigate the effect of Eucalyptus globulus EO (EuEO) in a rat Parkinson model induced by bilateral lesion with the neurotoxin, 6-hydroxydopamine (6-OHDA). Methods: EuEO composition was determined by GC–MS. Wistar rats were treated with EuEO (25 mg/kg, i.p) for 36 days, and behavioral tests (Barnes maze, wire mesh ramp, and grip strength) were performed 18 days after 6-OHDA application. We evaluated tyrosine hydroxylase (TH) and dopamine transporter (DAT) expression in the brain caudate-putamen unit; inflammatory cytokine (TNF-α, IL-6) expression in the hippocampus; liver, kidney, and gut histology; serum parameters; and hepatic lipid content. Results: Our findings indicate that EuEO is mainly composed of 1,8-cineole (81.8 %) and that, in the parkinsonian rats, it improved impairments in spatial memory, motor performance, and strength; increased TH and DAT protein content; decreased TNF-α expression; diminished liver lipid content and body weight gain without changes in the rats’ food/water consumption or their serum lipid levels; diminished transaminase and alkaline phosphatase activity, and the albumin/globulin ratio. Discussion: Although 1,8-cineole is a well-documented bioactive compound, further research is required to evaluate its potential synergistic or additive interactions with minor components. Our findings highlight the remarkable neuroprotective potential of EuEO and encourage further research of this very promising therapeutic alternative. |
| format | Article |
| id | doaj-art-7d3f6a83fea44cd586491c5455c4059b |
| institution | Kabale University |
| issn | 2667-1425 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj-art-7d3f6a83fea44cd586491c5455c4059b2025-02-08T05:01:36ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252025-03-0114100584Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's diseaseAracely Janneth Naranjo-Viteri0Matías Jávega Cometto1Matías Caverzan2Leandro Gabriel Champarini3María Paula Zunino4Rogelio E. Abburra5Claudia B. Hereñú6Rosana Crespo7Instituto de Farmacología Experimental de Córdoba (IFEC-CONICET), Departamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, ArgentinaInstituto de Farmacología Experimental de Córdoba (IFEC-CONICET), Departamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, ArgentinaInstituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados (IITEMA-CONICET), Departamento de Patología Animal, Facultad de Agronomía y Veterinaria, Universidad Nacional de Rio Cuarto, Rio Cuarto, ArgentinaInstituto de Farmacología Experimental de Córdoba (IFEC-CONICET), Departamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, ArgentinaInstituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, ArgentinaCátedra de Química Analítica Instrumental. Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, ArgentinaInstituto de Farmacología Experimental de Córdoba (IFEC-CONICET), Departamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, ArgentinaInstituto de Farmacología Experimental de Córdoba (IFEC-CONICET), Departamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Corresponding author.Introduction: Essential oil (EO) of eucalyptus has been commonly used as a traditional Chinese medicine to treat illnesses such as influenza, dysentery and eczema, and it is widely used in the pharmaceutical industry. However, its neuroprotective effects have not been fully demonstrated. Given the rising prevalence of the neurodegenerative disorder, Parkinson's disease, in aging populations, this study aims to investigate the effect of Eucalyptus globulus EO (EuEO) in a rat Parkinson model induced by bilateral lesion with the neurotoxin, 6-hydroxydopamine (6-OHDA). Methods: EuEO composition was determined by GC–MS. Wistar rats were treated with EuEO (25 mg/kg, i.p) for 36 days, and behavioral tests (Barnes maze, wire mesh ramp, and grip strength) were performed 18 days after 6-OHDA application. We evaluated tyrosine hydroxylase (TH) and dopamine transporter (DAT) expression in the brain caudate-putamen unit; inflammatory cytokine (TNF-α, IL-6) expression in the hippocampus; liver, kidney, and gut histology; serum parameters; and hepatic lipid content. Results: Our findings indicate that EuEO is mainly composed of 1,8-cineole (81.8 %) and that, in the parkinsonian rats, it improved impairments in spatial memory, motor performance, and strength; increased TH and DAT protein content; decreased TNF-α expression; diminished liver lipid content and body weight gain without changes in the rats’ food/water consumption or their serum lipid levels; diminished transaminase and alkaline phosphatase activity, and the albumin/globulin ratio. Discussion: Although 1,8-cineole is a well-documented bioactive compound, further research is required to evaluate its potential synergistic or additive interactions with minor components. Our findings highlight the remarkable neuroprotective potential of EuEO and encourage further research of this very promising therapeutic alternative.http://www.sciencedirect.com/science/article/pii/S2667142525000132Eucalyptus globulusEssential oil6-OHDAParkinson modelBehavioral testsSystemic effects |
| spellingShingle | Aracely Janneth Naranjo-Viteri Matías Jávega Cometto Matías Caverzan Leandro Gabriel Champarini María Paula Zunino Rogelio E. Abburra Claudia B. Hereñú Rosana Crespo Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease Pharmacological Research - Modern Chinese Medicine Eucalyptus globulus Essential oil 6-OHDA Parkinson model Behavioral tests Systemic effects |
| title | Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease |
| title_full | Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease |
| title_fullStr | Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease |
| title_full_unstemmed | Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease |
| title_short | Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease |
| title_sort | assessing the neuroprotective potential of eucalyptus globulus essential oil in a 6 hydroxydopamine rat model of parkinson s disease |
| topic | Eucalyptus globulus Essential oil 6-OHDA Parkinson model Behavioral tests Systemic effects |
| url | http://www.sciencedirect.com/science/article/pii/S2667142525000132 |
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