Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk
Abstract Background The eradication of the Hepatitis C Virus (HCV) reduce the risk of liver cancer (LC), but lifestyle changes after cure may counterbalance its benefit. Our study investigates lifestyle changes that occur in HCV patients with Sustained Virological Response (SVR) after direct-acting...
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BMC
2025-02-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03611-w |
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| author | Núria Granel Gemma Iserte Concepció Bartres Neus Llarch Anna Pla Víctor Sapena Zoe Mariño Sabela Lens Ramón Vilana Isabel Nuñez Anna Darnell Ernest Belmonte Ángeles García-Criado Alba Díaz Marco Sanduzzi-Zamparelli Carla Fuster Sergio Muñoz-Martínez Carmen Ayuso Jordi Rimola Alejandro Forner Alexandre Soler Ferran Torres José Ríos Jordi Bruix Andrew M. Moon Xavier Forns María Reig |
| author_facet | Núria Granel Gemma Iserte Concepció Bartres Neus Llarch Anna Pla Víctor Sapena Zoe Mariño Sabela Lens Ramón Vilana Isabel Nuñez Anna Darnell Ernest Belmonte Ángeles García-Criado Alba Díaz Marco Sanduzzi-Zamparelli Carla Fuster Sergio Muñoz-Martínez Carmen Ayuso Jordi Rimola Alejandro Forner Alexandre Soler Ferran Torres José Ríos Jordi Bruix Andrew M. Moon Xavier Forns María Reig |
| author_sort | Núria Granel |
| collection | DOAJ |
| description | Abstract Background The eradication of the Hepatitis C Virus (HCV) reduce the risk of liver cancer (LC), but lifestyle changes after cure may counterbalance its benefit. Our study investigates lifestyle changes that occur in HCV patients with Sustained Virological Response (SVR) after direct-acting antiviral (DAA) treatment. Methods In this prospective, single-center study, HCV patients with advanced liver disease (F3/F4) treated and cured with DAA were invited to fill a lifestyle habits questionnaire in and perform abdominal ultrasound (US), blood extraction and anthropometric measurements within the 1st month after SVR and every 6 months thereafter until 48 months of follow-up, LC development, death, or loss to follow-up. Results This prospective cohort included 182 patients with SVR after DAA in this first analysis through the 4 years of follow-up. At the time of SVR, 65.9% had cirrhosis, median BMI was 27.1 kg/m2, 74.2% were overweight or obese and 6.6% had an US with hepatic steatosis. Within a year of SVR, 9% of males and 4% of females progressed from normal weight to overweight/obesity and 19.4% increased alcohol consumption. At 48 months, there were statistically significant increases in BMI (0.75, p = 0.001) and alcohol consumption (6.4% p = 0.007). Conclusions In this prospective cohort, successful HCV therapy was followed by significant changes in lifestyle habits translating into increases in BMI and alcohol consumption. These post-SVR changes raise concerns that the chemopreventive benefits of HCV cure may be counterbalanced by increased risks of liver disease progression and LC development from metabolic risk factors and alcohol use. Post-SVR, patients may benefit from intensive counseling and pharmacotherapy to address obesity and alcohol use. Trial registration/ clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-7f74b18d10a14b1d885d1791a28f9711 |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-7f74b18d10a14b1d885d1791a28f97112025-02-09T12:39:39ZengBMCBMC Gastroenterology1471-230X2025-02-0125111010.1186/s12876-025-03611-wLiver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer riskNúria Granel0Gemma Iserte1Concepció Bartres2Neus Llarch3Anna Pla4Víctor Sapena5Zoe Mariño6Sabela Lens7Ramón Vilana8Isabel Nuñez9Anna Darnell10Ernest Belmonte11Ángeles García-Criado12Alba Díaz13Marco Sanduzzi-Zamparelli14Carla Fuster15Sergio Muñoz-Martínez16Carmen Ayuso17Jordi Rimola18Alejandro Forner19Alexandre Soler20Ferran Torres21José Ríos22Jordi Bruix23Andrew M. Moon24Xavier Forns25María Reig26Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Liver Unit, Hospital Clinic de BarcelonaBarcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Liver Unit, Hospital Clinic de BarcelonaBarcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Liver Unit, Hospital Clinic de BarcelonaLiver Unit, Hospital Clinic de BarcelonaBarcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Liver Oncology Unit, Radiology Department, Hospital Clinic de BarcelonaBarcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Biostatistics Unit, Faculty of Medicine, Universitat Autònoma de Barcelona (UAB)Department of Clinical Farmacology Hospital Clinic and Medical Statistics Core Facility, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS)Barcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Division of Gastroenterology and Hepatology, University of North CarolinaLiver Unit, Hospital Clinic de BarcelonaBarcelona Clinic Liver Cancer (BCLC) group. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Abstract Background The eradication of the Hepatitis C Virus (HCV) reduce the risk of liver cancer (LC), but lifestyle changes after cure may counterbalance its benefit. Our study investigates lifestyle changes that occur in HCV patients with Sustained Virological Response (SVR) after direct-acting antiviral (DAA) treatment. Methods In this prospective, single-center study, HCV patients with advanced liver disease (F3/F4) treated and cured with DAA were invited to fill a lifestyle habits questionnaire in and perform abdominal ultrasound (US), blood extraction and anthropometric measurements within the 1st month after SVR and every 6 months thereafter until 48 months of follow-up, LC development, death, or loss to follow-up. Results This prospective cohort included 182 patients with SVR after DAA in this first analysis through the 4 years of follow-up. At the time of SVR, 65.9% had cirrhosis, median BMI was 27.1 kg/m2, 74.2% were overweight or obese and 6.6% had an US with hepatic steatosis. Within a year of SVR, 9% of males and 4% of females progressed from normal weight to overweight/obesity and 19.4% increased alcohol consumption. At 48 months, there were statistically significant increases in BMI (0.75, p = 0.001) and alcohol consumption (6.4% p = 0.007). Conclusions In this prospective cohort, successful HCV therapy was followed by significant changes in lifestyle habits translating into increases in BMI and alcohol consumption. These post-SVR changes raise concerns that the chemopreventive benefits of HCV cure may be counterbalanced by increased risks of liver disease progression and LC development from metabolic risk factors and alcohol use. Post-SVR, patients may benefit from intensive counseling and pharmacotherapy to address obesity and alcohol use. Trial registration/ clinical trial number Not applicable.https://doi.org/10.1186/s12876-025-03611-wLifestyleHCVNurseLiver cancerHCCSteatotic Liver diseases |
| spellingShingle | Núria Granel Gemma Iserte Concepció Bartres Neus Llarch Anna Pla Víctor Sapena Zoe Mariño Sabela Lens Ramón Vilana Isabel Nuñez Anna Darnell Ernest Belmonte Ángeles García-Criado Alba Díaz Marco Sanduzzi-Zamparelli Carla Fuster Sergio Muñoz-Martínez Carmen Ayuso Jordi Rimola Alejandro Forner Alexandre Soler Ferran Torres José Ríos Jordi Bruix Andrew M. Moon Xavier Forns María Reig Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk BMC Gastroenterology Lifestyle HCV Nurse Liver cancer HCC Steatotic Liver diseases |
| title | Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk |
| title_full | Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk |
| title_fullStr | Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk |
| title_full_unstemmed | Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk |
| title_short | Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk |
| title_sort | liver cancer risk and changes in lifestyle habits after successful hepatitis c virus therapy post daa hcv therapy lifestyle changes and liver cancer risk |
| topic | Lifestyle HCV Nurse Liver cancer HCC Steatotic Liver diseases |
| url | https://doi.org/10.1186/s12876-025-03611-w |
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