Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2
Spices and Mediterranean medicinal plants provide a rich resource for novel antiviral drug development. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic with devastating outcomes, and hence, there is a global need to search for small-molecule...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia.edu Journals
2024-08-01
|
| Series: | Academia Biology |
| Online Access: | https://www.academia.edu/122696296/Antiviral_activity_of_natural_compounds_extracted_from_Mediterranean_medicinal_plants_against_SARS_CoV_2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823859550217830400 |
|---|---|
| author | Stephanie Ghio Jean-Pierre Brincat Yuksel Cetin Frederick Lia |
| author_facet | Stephanie Ghio Jean-Pierre Brincat Yuksel Cetin Frederick Lia |
| author_sort | Stephanie Ghio |
| collection | DOAJ |
| description |
Spices and Mediterranean medicinal plants provide a rich resource for novel antiviral drug development. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic with devastating outcomes, and hence, there is a global need to search for small-molecule inhibitors that can act against this viral pathogen. This review highlights studies that have investigated the antiviral activities of spices and Mediterranean herbs, as well as their mechanism of action against SARS-CoV-2. Potential therapeutic target mechanisms addressed in this review comprise both host-directed and virus-directed therapies. Host-directed therapies include the inhibition of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). Virus-directed therapies include inhibition of papain-like protease (PLpro) and the main protease, 3-chymotrypsin-like protease (3CLpro). Though numerous studies have been conducted on natural products, many of these studies have been performed in silico and require further research to verify the suggested therapeutic properties. 3CLpro has been identified as the target with the largest number of proven in vitro results, with compounds from different classes of molecules shown to inhibit this essential viral protease. In silico studies have confirmed the in vitro results, while providing additional mechanistic insights. Phytocompounds can serve as a foundation for designing new antiviral therapies. |
| format | Article |
| id | doaj-art-7f7fc88ba29746c9b30f0b939ad7f6fc |
| institution | Kabale University |
| issn | 2837-4010 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Academia.edu Journals |
| record_format | Article |
| series | Academia Biology |
| spelling | doaj-art-7f7fc88ba29746c9b30f0b939ad7f6fc2025-02-11T00:43:43ZengAcademia.edu JournalsAcademia Biology2837-40102024-08-012310.20935/AcadBiol7297Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2Stephanie Ghio0Jean-Pierre Brincat1Yuksel Cetin2Frederick Lia3Institute of Applied Sciences, Malta College of Arts, Science & Technology (MCAST), Triq Kordin, Paola PLA9032, Malta.Institute of Applied Sciences, Malta College of Arts, Science & Technology (MCAST), Triq Kordin, Paola PLA9032, Malta.Medical Biotechnology Unit, Life Sciences, TÜBİTAK Marmara Research Center, Gebze, Kocaeli 41470, Turkey.Institute of Applied Sciences, Malta College of Arts, Science & Technology (MCAST), Triq Kordin, Paola PLA9032, Malta. Spices and Mediterranean medicinal plants provide a rich resource for novel antiviral drug development. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic with devastating outcomes, and hence, there is a global need to search for small-molecule inhibitors that can act against this viral pathogen. This review highlights studies that have investigated the antiviral activities of spices and Mediterranean herbs, as well as their mechanism of action against SARS-CoV-2. Potential therapeutic target mechanisms addressed in this review comprise both host-directed and virus-directed therapies. Host-directed therapies include the inhibition of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). Virus-directed therapies include inhibition of papain-like protease (PLpro) and the main protease, 3-chymotrypsin-like protease (3CLpro). Though numerous studies have been conducted on natural products, many of these studies have been performed in silico and require further research to verify the suggested therapeutic properties. 3CLpro has been identified as the target with the largest number of proven in vitro results, with compounds from different classes of molecules shown to inhibit this essential viral protease. In silico studies have confirmed the in vitro results, while providing additional mechanistic insights. Phytocompounds can serve as a foundation for designing new antiviral therapies.https://www.academia.edu/122696296/Antiviral_activity_of_natural_compounds_extracted_from_Mediterranean_medicinal_plants_against_SARS_CoV_2 |
| spellingShingle | Stephanie Ghio Jean-Pierre Brincat Yuksel Cetin Frederick Lia Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 Academia Biology |
| title | Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 |
| title_full | Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 |
| title_fullStr | Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 |
| title_full_unstemmed | Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 |
| title_short | Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 |
| title_sort | antiviral activity of natural compounds extracted from mediterranean medicinal plants against sars cov 2 |
| url | https://www.academia.edu/122696296/Antiviral_activity_of_natural_compounds_extracted_from_Mediterranean_medicinal_plants_against_SARS_CoV_2 |
| work_keys_str_mv | AT stephanieghio antiviralactivityofnaturalcompoundsextractedfrommediterraneanmedicinalplantsagainstsarscov2 AT jeanpierrebrincat antiviralactivityofnaturalcompoundsextractedfrommediterraneanmedicinalplantsagainstsarscov2 AT yukselcetin antiviralactivityofnaturalcompoundsextractedfrommediterraneanmedicinalplantsagainstsarscov2 AT fredericklia antiviralactivityofnaturalcompoundsextractedfrommediterraneanmedicinalplantsagainstsarscov2 |