Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures
Abstract Objectives To determine the incidence of later epilepsy in full‐term infants with neonatal encephalopathy (NE) who undergo continuous electroencephalography (cEEG) monitoring in the neonatal period and to identify potential predictors of later epilepsy both in infants with and without elect...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-02-01
|
| Series: | Epilepsia Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/epi4.13089 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206489818595328 |
|---|---|
| author | Carol M. Stephens Jacopo Proietti Sean R. Mathieson Vicki Livingstone Brian McNamara Niamh McSweeney Olivia O'Mahony Brian H. Walsh Deirdre M. Murray Geraldine B. Boylan |
| author_facet | Carol M. Stephens Jacopo Proietti Sean R. Mathieson Vicki Livingstone Brian McNamara Niamh McSweeney Olivia O'Mahony Brian H. Walsh Deirdre M. Murray Geraldine B. Boylan |
| author_sort | Carol M. Stephens |
| collection | DOAJ |
| description | Abstract Objectives To determine the incidence of later epilepsy in full‐term infants with neonatal encephalopathy (NE) who undergo continuous electroencephalography (cEEG) monitoring in the neonatal period and to identify potential predictors of later epilepsy both in infants with and without electrographic neonatal seizures (ENS). Methods This was a retrospective observational study performed at Cork University Maternity Hospital, Cork, Ireland, between 2003 and 2019. All term infants with NE had a minimum of 2 h of cEEG monitoring in the neonatal period. ENS were identified via cEEG monitoring. Pediatric medical charts were reviewed to determine if epilepsy developed after the neonatal period and to determine potential predictors of epilepsy in infants both with and without ENS. Results Two hundred and eighty infants were included. The overall incidence rate of epilepsy was 17.55 per 1000 person‐years (95% CI: 10.91 to 28.23). In infants with ENS (n = 82), the incidence rate was 39.27 per 1000 person‐years (95% CI: 22.30 to 69.16). In infants without ENS (n = 198), the incidence rate was 7.54 per 1000 person‐years (95% CI: 3.14 to 18.12). The incidence rate was significantly higher in the ENS group compared to the non‐ENS group (p‐value = 0.002). Several potential predictors for the development of later epilepsy were identified including infants delivered vaginally, low Apgar scores at 1 and 5 min, severe HIE diagnosis, presence of ENS, a severely abnormal EEG background and an abnormal brain MRI. Significance Following NE, term infants are at risk of epilepsy with a significantly higher incidence rate in infants who experience ENS compared to those who did not. Close follow‐up is required in both groups well into the childhood period. Plain Language Summary This study aimed to determine the occurrence of epilepsy in children who were monitored for seizures in the newborn period. The occurrence of epilepsy was higher in infants who experienced seizures in the newborn period compared to those who did not. Several potential predictors of later epilepsy were identified in both groups of infants (those with and without seizures in the newborn period). Both groups of infants require close follow‐up in childhood. |
| format | Article |
| id | doaj-art-7fe13f47cecf46fe8aa7062d0a906470 |
| institution | Kabale University |
| issn | 2470-9239 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Epilepsia Open |
| spelling | doaj-art-7fe13f47cecf46fe8aa7062d0a9064702025-02-07T09:12:45ZengWileyEpilepsia Open2470-92392025-02-0110115516710.1002/epi4.13089Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic SeizuresCarol M. Stephens0Jacopo Proietti1Sean R. Mathieson2Vicki Livingstone3Brian McNamara4Niamh McSweeney5Olivia O'Mahony6Brian H. Walsh7Deirdre M. Murray8Geraldine B. Boylan9INFANT Research Centre University College Cork Cork IrelandINFANT Research Centre University College Cork Cork IrelandINFANT Research Centre University College Cork Cork IrelandINFANT Research Centre University College Cork Cork IrelandDepartment of Neurophysiology Cork University Hospital Cork IrelandDepartment of Paediatrics and Child Health University College Cork Cork IrelandDepartment of Paediatric Neurology Cork University Hospital Cork IrelandINFANT Research Centre University College Cork Cork IrelandINFANT Research Centre University College Cork Cork IrelandINFANT Research Centre University College Cork Cork IrelandAbstract Objectives To determine the incidence of later epilepsy in full‐term infants with neonatal encephalopathy (NE) who undergo continuous electroencephalography (cEEG) monitoring in the neonatal period and to identify potential predictors of later epilepsy both in infants with and without electrographic neonatal seizures (ENS). Methods This was a retrospective observational study performed at Cork University Maternity Hospital, Cork, Ireland, between 2003 and 2019. All term infants with NE had a minimum of 2 h of cEEG monitoring in the neonatal period. ENS were identified via cEEG monitoring. Pediatric medical charts were reviewed to determine if epilepsy developed after the neonatal period and to determine potential predictors of epilepsy in infants both with and without ENS. Results Two hundred and eighty infants were included. The overall incidence rate of epilepsy was 17.55 per 1000 person‐years (95% CI: 10.91 to 28.23). In infants with ENS (n = 82), the incidence rate was 39.27 per 1000 person‐years (95% CI: 22.30 to 69.16). In infants without ENS (n = 198), the incidence rate was 7.54 per 1000 person‐years (95% CI: 3.14 to 18.12). The incidence rate was significantly higher in the ENS group compared to the non‐ENS group (p‐value = 0.002). Several potential predictors for the development of later epilepsy were identified including infants delivered vaginally, low Apgar scores at 1 and 5 min, severe HIE diagnosis, presence of ENS, a severely abnormal EEG background and an abnormal brain MRI. Significance Following NE, term infants are at risk of epilepsy with a significantly higher incidence rate in infants who experience ENS compared to those who did not. Close follow‐up is required in both groups well into the childhood period. Plain Language Summary This study aimed to determine the occurrence of epilepsy in children who were monitored for seizures in the newborn period. The occurrence of epilepsy was higher in infants who experienced seizures in the newborn period compared to those who did not. Several potential predictors of later epilepsy were identified in both groups of infants (those with and without seizures in the newborn period). Both groups of infants require close follow‐up in childhood.https://doi.org/10.1002/epi4.13089EEGepilepsyneonatal encephalopathyseizures |
| spellingShingle | Carol M. Stephens Jacopo Proietti Sean R. Mathieson Vicki Livingstone Brian McNamara Niamh McSweeney Olivia O'Mahony Brian H. Walsh Deirdre M. Murray Geraldine B. Boylan Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures Epilepsia Open EEG epilepsy neonatal encephalopathy seizures |
| title | Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures |
| title_full | Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures |
| title_fullStr | Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures |
| title_full_unstemmed | Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures |
| title_short | Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures |
| title_sort | incidence and predictors of later epilepsy in neonates with encephalopathy the impact of electrographic seizures |
| topic | EEG epilepsy neonatal encephalopathy seizures |
| url | https://doi.org/10.1002/epi4.13089 |
| work_keys_str_mv | AT carolmstephens incidenceandpredictorsoflaterepilepsyinneonateswithencephalopathytheimpactofelectrographicseizures AT jacopoproietti incidenceandpredictorsoflaterepilepsyinneonateswithencephalopathytheimpactofelectrographicseizures AT seanrmathieson incidenceandpredictorsoflaterepilepsyinneonateswithencephalopathytheimpactofelectrographicseizures AT vickilivingstone incidenceandpredictorsoflaterepilepsyinneonateswithencephalopathytheimpactofelectrographicseizures AT brianmcnamara incidenceandpredictorsoflaterepilepsyinneonateswithencephalopathytheimpactofelectrographicseizures AT niamhmcsweeney incidenceandpredictorsoflaterepilepsyinneonateswithencephalopathytheimpactofelectrographicseizures AT oliviaomahony incidenceandpredictorsoflaterepilepsyinneonateswithencephalopathytheimpactofelectrographicseizures AT brianhwalsh incidenceandpredictorsoflaterepilepsyinneonateswithencephalopathytheimpactofelectrographicseizures AT deirdremmurray incidenceandpredictorsoflaterepilepsyinneonateswithencephalopathytheimpactofelectrographicseizures AT geraldinebboylan incidenceandpredictorsoflaterepilepsyinneonateswithencephalopathytheimpactofelectrographicseizures |