Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis Treatment
Yuqing Lu,1,* Yan Wang,2,* Yize Li,1,* Yunan Li,1 Yao-Wen Jiang,1,3 Jingjing Li1,3 1School of Medical Imaging, Xuzhou Medical University, Xuzhou, 221004, People’s Republic of China; 2The First Clinical Medical College, Xuzhou Medical University, Xuzhou, 221004, People’s Repub...
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Dove Medical Press
2025-02-01
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| author | Lu Y Wang Y Li Y Li Y Jiang YW Li J |
| author_facet | Lu Y Wang Y Li Y Li Y Jiang YW Li J |
| author_sort | Lu Y |
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| description | Yuqing Lu,1,* Yan Wang,2,* Yize Li,1,* Yunan Li,1 Yao-Wen Jiang,1,3 Jingjing Li1,3 1School of Medical Imaging, Xuzhou Medical University, Xuzhou, 221004, People’s Republic of China; 2The First Clinical Medical College, Xuzhou Medical University, Xuzhou, 221004, People’s Republic of China; 3Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yao-Wen Jiang; Jingjing Li, Email [email protected]; [email protected]: Photothermal therapy (PTT) is attracting increasing attention in treating atherosclerotic plaques. However, PTT can induce inflammatory responses, in turn stimulating the regeneration of atherosclerosis and hindering subsequent therapy.Methods: In this paper, a multifunctional nanoparticle (Au NR@SiO2/RSNO/DS, GSNPD) for the synergistic treatment of atherosclerosis through PTT and anti-inflammation effects was developed. The preparation and characterization of GSNPD, their cellular toxicity, photothermal conversion and targeted ablation efficiency, anti-inflammation and ROS scavenging effect, as well as the inhibition of foam cell formation were studied in vitro.Results: The experimental results showed that the fabricated GSNPD NPs displayed positive effects on anti-atherosclerosis by pro-inflammatory macrophages ablation, NO production and ROS scavenging.Discussion: GSNPD NPs were designed to effectively and accurately ablate pro-inflammatory macrophages by recognizing and targeting to SR-A overexpressed on the activated macrophages of arterial plaques via PTT, and simultaneous inhibit the PTT-induced inflammation through the laser-activated NO release in situ. This match of therapeutic agents and inhibitors not only achieves good therapeutic effects but also minimizes side effects as much as possible, which may provide an effective way for PTT-based treatment of atherosclerosis.Keywords: gold nanorods, photothermal therapy, NO, activated macrophages, atherosclerosis |
| format | Article |
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| institution | Kabale University |
| issn | 1178-2013 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj-art-7ffce39799e14800a650bbfd1d71e1b02025-02-09T16:10:20ZengDove Medical PressInternational Journal of Nanomedicine1178-20132025-02-01Volume 201731174699990Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis TreatmentLu YWang YLi YLi YJiang YWLi JYuqing Lu,1,* Yan Wang,2,* Yize Li,1,* Yunan Li,1 Yao-Wen Jiang,1,3 Jingjing Li1,3 1School of Medical Imaging, Xuzhou Medical University, Xuzhou, 221004, People’s Republic of China; 2The First Clinical Medical College, Xuzhou Medical University, Xuzhou, 221004, People’s Republic of China; 3Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yao-Wen Jiang; Jingjing Li, Email [email protected]; [email protected]: Photothermal therapy (PTT) is attracting increasing attention in treating atherosclerotic plaques. However, PTT can induce inflammatory responses, in turn stimulating the regeneration of atherosclerosis and hindering subsequent therapy.Methods: In this paper, a multifunctional nanoparticle (Au NR@SiO2/RSNO/DS, GSNPD) for the synergistic treatment of atherosclerosis through PTT and anti-inflammation effects was developed. The preparation and characterization of GSNPD, their cellular toxicity, photothermal conversion and targeted ablation efficiency, anti-inflammation and ROS scavenging effect, as well as the inhibition of foam cell formation were studied in vitro.Results: The experimental results showed that the fabricated GSNPD NPs displayed positive effects on anti-atherosclerosis by pro-inflammatory macrophages ablation, NO production and ROS scavenging.Discussion: GSNPD NPs were designed to effectively and accurately ablate pro-inflammatory macrophages by recognizing and targeting to SR-A overexpressed on the activated macrophages of arterial plaques via PTT, and simultaneous inhibit the PTT-induced inflammation through the laser-activated NO release in situ. This match of therapeutic agents and inhibitors not only achieves good therapeutic effects but also minimizes side effects as much as possible, which may provide an effective way for PTT-based treatment of atherosclerosis.Keywords: gold nanorods, photothermal therapy, NO, activated macrophages, atherosclerosishttps://www.dovepress.com/golden-tandem-of-photothermal-ablation-and-simultaneous-anti-inflammat-peer-reviewed-fulltext-article-IJNgold nanorodsphotothermal therapynoactivated macrophagesatherosclerosis |
| spellingShingle | Lu Y Wang Y Li Y Li Y Jiang YW Li J Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis Treatment International Journal of Nanomedicine gold nanorods photothermal therapy no activated macrophages atherosclerosis |
| title | Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis Treatment |
| title_full | Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis Treatment |
| title_fullStr | Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis Treatment |
| title_full_unstemmed | Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis Treatment |
| title_short | Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis Treatment |
| title_sort | golden tandem of photothermal ablation and simultaneous anti inflammation in one nanoparticle for activated macrophage targeted atherosclerosis treatment |
| topic | gold nanorods photothermal therapy no activated macrophages atherosclerosis |
| url | https://www.dovepress.com/golden-tandem-of-photothermal-ablation-and-simultaneous-anti-inflammat-peer-reviewed-fulltext-article-IJN |
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