Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers
Abstract Background and objective Noninvasive salivary biomarkers can be used to assess the cumulative subclinical health impacts of social and environmental stressors. We evaluated seven salivary biomarkers of neuroendocrine and immune functions and a group index of physiological dysregulation base...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-024-07056-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823863427847684096 |
|---|---|
| author | Andrey I. Egorov William Xue Jason Kobylanski Miyu Fuzawa Shannon M. Griffin Timothy J. Wade Michael Nye |
| author_facet | Andrey I. Egorov William Xue Jason Kobylanski Miyu Fuzawa Shannon M. Griffin Timothy J. Wade Michael Nye |
| author_sort | Andrey I. Egorov |
| collection | DOAJ |
| description | Abstract Background and objective Noninvasive salivary biomarkers can be used to assess the cumulative subclinical health impacts of social and environmental stressors. We evaluated seven salivary biomarkers of neuroendocrine and immune functions and a group index of physiological dysregulation based on these biomarkers in a pilot survey in a socioeconomically disadvantaged population. Results Participants recruited at subsidized public housing projects in Denver, Colorado, completed a sociodemographic, behavioral, and health questionnaire and used passive drool samplers to collect five saliva samples over the course of 1 day. Samples were tested for the neuroendocrine biomarkers alpha-amylase, cortisol, and dehydroepiandrosterone (DHEA) as well as immune system/inflammation biomarkers C-reactive protein (CRP), interleukin (IL)-1β, IL-6 and total immunoglobulin A (IgA). A composite Inflammation and Physiological Dysregulation Index (IPDI) was calculated as a count of potentially unhealthy values of dichotomized biomarkers. In 20 individuals who completed the survey (average age 46 years, 75% females), allergy to house dust was significantly associated with increased IPDI (adjusted for age) and significantly increased odds of potentially unhealthy values of total IgA, IL-1β, and CRP. Age, obesity, diabetes, allergy to pollen, recent loss of employment, and depression, anxiety, and stress scores from the standard DASS-21 questionnaire were positively but not significantly (0.05 < p < 0.2) associated with IPDI. This project demonstrated an application of a composite index based on noninvasive salivary biomarkers to assess subclinical health impacts of chronic social stressors. |
| format | Article |
| id | doaj-art-8072ab24a1f746aab2eb9e920afc0f42 |
| institution | Kabale University |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-8072ab24a1f746aab2eb9e920afc0f422025-02-09T12:09:54ZengBMCBMC Research Notes1756-05002025-02-0118111010.1186/s13104-024-07056-4Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkersAndrey I. Egorov0William Xue1Jason Kobylanski2Miyu Fuzawa3Shannon M. Griffin4Timothy J. Wade5Michael Nye6Office of Research and Development, U.S. Environmental Protection AgencyORAU Contractor to the U.S. Environmental Protection AgencyORAU Contractor to the U.S. Environmental Protection AgencyORAU Contractor to the U.S. Environmental Protection AgencyOffice of Research and Development, U.S. Environmental Protection AgencyOffice of Research and Development, U.S. Environmental Protection AgencyOffice of Research and Development, U.S. Environmental Protection AgencyAbstract Background and objective Noninvasive salivary biomarkers can be used to assess the cumulative subclinical health impacts of social and environmental stressors. We evaluated seven salivary biomarkers of neuroendocrine and immune functions and a group index of physiological dysregulation based on these biomarkers in a pilot survey in a socioeconomically disadvantaged population. Results Participants recruited at subsidized public housing projects in Denver, Colorado, completed a sociodemographic, behavioral, and health questionnaire and used passive drool samplers to collect five saliva samples over the course of 1 day. Samples were tested for the neuroendocrine biomarkers alpha-amylase, cortisol, and dehydroepiandrosterone (DHEA) as well as immune system/inflammation biomarkers C-reactive protein (CRP), interleukin (IL)-1β, IL-6 and total immunoglobulin A (IgA). A composite Inflammation and Physiological Dysregulation Index (IPDI) was calculated as a count of potentially unhealthy values of dichotomized biomarkers. In 20 individuals who completed the survey (average age 46 years, 75% females), allergy to house dust was significantly associated with increased IPDI (adjusted for age) and significantly increased odds of potentially unhealthy values of total IgA, IL-1β, and CRP. Age, obesity, diabetes, allergy to pollen, recent loss of employment, and depression, anxiety, and stress scores from the standard DASS-21 questionnaire were positively but not significantly (0.05 < p < 0.2) associated with IPDI. This project demonstrated an application of a composite index based on noninvasive salivary biomarkers to assess subclinical health impacts of chronic social stressors.https://doi.org/10.1186/s13104-024-07056-4Physiological dysregulationInflammationAllostatic loadSalivaBiomarkersStress |
| spellingShingle | Andrey I. Egorov William Xue Jason Kobylanski Miyu Fuzawa Shannon M. Griffin Timothy J. Wade Michael Nye Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers BMC Research Notes Physiological dysregulation Inflammation Allostatic load Saliva Biomarkers Stress |
| title | Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers |
| title_full | Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers |
| title_fullStr | Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers |
| title_full_unstemmed | Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers |
| title_short | Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers |
| title_sort | pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers |
| topic | Physiological dysregulation Inflammation Allostatic load Saliva Biomarkers Stress |
| url | https://doi.org/10.1186/s13104-024-07056-4 |
| work_keys_str_mv | AT andreyiegorov pilotapplicationofaninflammationandphysiologicaldysregulationindexbasedonnoninvasivesalivarybiomarkers AT williamxue pilotapplicationofaninflammationandphysiologicaldysregulationindexbasedonnoninvasivesalivarybiomarkers AT jasonkobylanski pilotapplicationofaninflammationandphysiologicaldysregulationindexbasedonnoninvasivesalivarybiomarkers AT miyufuzawa pilotapplicationofaninflammationandphysiologicaldysregulationindexbasedonnoninvasivesalivarybiomarkers AT shannonmgriffin pilotapplicationofaninflammationandphysiologicaldysregulationindexbasedonnoninvasivesalivarybiomarkers AT timothyjwade pilotapplicationofaninflammationandphysiologicaldysregulationindexbasedonnoninvasivesalivarybiomarkers AT michaelnye pilotapplicationofaninflammationandphysiologicaldysregulationindexbasedonnoninvasivesalivarybiomarkers |