Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?
Objective: To find out the relationship of maternal serum levels of kisspeptin with gestational diabetes mellitus status. Study Design: A total of 158 pregnant women between 24 and 28 weeks of gestation were divided into two groups according to gestational diabetes mellitus status: (i) Pregnant wo...
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| Format: | Article |
| Language: | English |
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Medical Network
2020-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/946 |
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| author | Emine Arslan Umit Gorkem Cihan Togrul |
| author_facet | Emine Arslan Umit Gorkem Cihan Togrul |
| author_sort | Emine Arslan |
| collection | DOAJ |
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Objective: To find out the relationship of maternal serum levels of kisspeptin with gestational diabetes mellitus status.
Study Design: A total of 158 pregnant women between 24 and 28 weeks of gestation were divided into two groups according to gestational diabetes mellitus status: (i) Pregnant women with gestational diabetes mellitus (gestational diabetes mellitus group, n=76) and (ii) Healthy pregnant women (control group, n=82). Maternal serum concentrations of kisspeptin, insulin, and homeostasis model assessment-insulin resistance were assessed.
Results: In both groups, there were no difference in terms of age and gestational age (p=0.058 and p=0.820, respectively). The median of body mass indices of both groups at 24 to 28 weeks of gestation were statistically similar (p=0.062). The serum concentrations of kisspeptin did not demonstrate significant differences between the gestational diabetes mellitus and control groups (p=0.28). There was a significant difference in terms of serum level of insulin and homeostasis model assessment-insulin resistance between the gestational diabetes mellitus and control groups (p<0.001).
Conclusion: No differences were found in serum kisspeptin levels between pregnant women with GDM and healthy pregnant women. Further prospective studies will be essential to elucidate the contribution of kisspeptin to gestational diabetes mellitus.
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| format | Article |
| id | doaj-art-81097710ee2443138ac1f6eb4cb82378 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-81097710ee2443138ac1f6eb4cb823782025-02-11T21:10:42ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182020-12-0126310.21613/GORM.2019.946Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?Emine Arslan0Umit Gorkem1Cihan Togrul2Hitit University Faculty of Medicine, Department of Obstetrics and GynecologyHitit University Faculty of Medicine, Department of Obstetrics and GynecologyHitit University Faculty of Medicine, Department of Obstetrics and Gynecology Objective: To find out the relationship of maternal serum levels of kisspeptin with gestational diabetes mellitus status. Study Design: A total of 158 pregnant women between 24 and 28 weeks of gestation were divided into two groups according to gestational diabetes mellitus status: (i) Pregnant women with gestational diabetes mellitus (gestational diabetes mellitus group, n=76) and (ii) Healthy pregnant women (control group, n=82). Maternal serum concentrations of kisspeptin, insulin, and homeostasis model assessment-insulin resistance were assessed. Results: In both groups, there were no difference in terms of age and gestational age (p=0.058 and p=0.820, respectively). The median of body mass indices of both groups at 24 to 28 weeks of gestation were statistically similar (p=0.062). The serum concentrations of kisspeptin did not demonstrate significant differences between the gestational diabetes mellitus and control groups (p=0.28). There was a significant difference in terms of serum level of insulin and homeostasis model assessment-insulin resistance between the gestational diabetes mellitus and control groups (p<0.001). Conclusion: No differences were found in serum kisspeptin levels between pregnant women with GDM and healthy pregnant women. Further prospective studies will be essential to elucidate the contribution of kisspeptin to gestational diabetes mellitus. https://gorm.com.tr/index.php/GORM/article/view/946Gestational diabetesKisspeptinMetabolism |
| spellingShingle | Emine Arslan Umit Gorkem Cihan Togrul Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus? Gynecology Obstetrics & Reproductive Medicine Gestational diabetes Kisspeptin Metabolism |
| title | Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus? |
| title_full | Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus? |
| title_fullStr | Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus? |
| title_full_unstemmed | Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus? |
| title_short | Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus? |
| title_sort | is there an association between kisspeptin levels and gestational diabetes mellitus |
| topic | Gestational diabetes Kisspeptin Metabolism |
| url | https://gorm.com.tr/index.php/GORM/article/view/946 |
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