Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3β
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Glycogen synthase kinase 3β (GSK-3β) plays a pivotal role in AD pathogenesis, particularly in tau protein hyperphosphorylation. Natural bioactive compounds have a wide range of so...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1497861/full |
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| author | Mei Wang Wendi Huang Juan Huang Juan Huang Yong Luo Yong Luo Nanqu Huang Nanqu Huang |
| author_facet | Mei Wang Wendi Huang Juan Huang Juan Huang Yong Luo Yong Luo Nanqu Huang Nanqu Huang |
| author_sort | Mei Wang |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Glycogen synthase kinase 3β (GSK-3β) plays a pivotal role in AD pathogenesis, particularly in tau protein hyperphosphorylation. Natural bioactive compounds have a wide range of sources, and medicinally valuable active compound can be extracted from plants, animals, and microorganisms. Currently, studies have found that various natural bioactive compounds from plants have the potential to improve AD symptoms, such as resveratrol and berberine. Therefore, this review examines the potential of natural bioactive compounds to modulate GSK-3β activity and inhibit the hyperphosphorylation of tau, offering a promising therapeutic strategy for AD. We summarize the current understanding of alkaloids, phenols, flavonoids, terpenoids and other natural compounds, highlighting their mechanisms of action and preclinical efficacy. |
| format | Article |
| id | doaj-art-810fb7779f1d4b0d853fd352d86888a7 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-810fb7779f1d4b0d853fd352d86888a72025-02-07T06:49:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.14978611497861Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3βMei Wang0Wendi Huang1Juan Huang2Juan Huang3Yong Luo4Yong Luo5Nanqu Huang6Nanqu Huang7Department of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, ChinaDepartment of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, ChinaKey Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, ChinaChinese Pharmacological Society-Guizhou Province Joint Laboratory for Pharmacology, Zunyi, Guizhou, ChinaDepartment of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, ChinaDepartment of Geriatrics, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, ChinaDepartment of Geriatrics, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, ChinaNational Drug Clinical Trial Institution, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, ChinaAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Glycogen synthase kinase 3β (GSK-3β) plays a pivotal role in AD pathogenesis, particularly in tau protein hyperphosphorylation. Natural bioactive compounds have a wide range of sources, and medicinally valuable active compound can be extracted from plants, animals, and microorganisms. Currently, studies have found that various natural bioactive compounds from plants have the potential to improve AD symptoms, such as resveratrol and berberine. Therefore, this review examines the potential of natural bioactive compounds to modulate GSK-3β activity and inhibit the hyperphosphorylation of tau, offering a promising therapeutic strategy for AD. We summarize the current understanding of alkaloids, phenols, flavonoids, terpenoids and other natural compounds, highlighting their mechanisms of action and preclinical efficacy.https://www.frontiersin.org/articles/10.3389/fphar.2025.1497861/fullAlzheimer’s diseaseGSK-3βtau proteintau hyperphosphorylationnatural bioactive compounds |
| spellingShingle | Mei Wang Wendi Huang Juan Huang Juan Huang Yong Luo Yong Luo Nanqu Huang Nanqu Huang Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3β Frontiers in Pharmacology Alzheimer’s disease GSK-3β tau protein tau hyperphosphorylation natural bioactive compounds |
| title | Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3β |
| title_full | Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3β |
| title_fullStr | Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3β |
| title_full_unstemmed | Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3β |
| title_short | Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3β |
| title_sort | natural bioactive compounds form herbal medicine in alzheimer s disease from the perspective of gsk 3β |
| topic | Alzheimer’s disease GSK-3β tau protein tau hyperphosphorylation natural bioactive compounds |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1497861/full |
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