The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study
Abstract Background and purpose Although Ginkgo biloba extract (GBE) has been shown to be effective in treating acute ischemic stroke (AIS) in several clinical trials, concerns regarding adverse events, such as bleeding, have been raised. This study aimed to investigate the mechanisms by which GBE i...
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BMC
2025-02-01
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| Series: | Thrombosis Journal |
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| Online Access: | https://doi.org/10.1186/s12959-025-00696-x |
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| author | Xiangqian Huang Xiaoming Zhang Jiahao Song Duo Lan Mengqi Wang Xunming Ji Da Zhou Ran Meng |
| author_facet | Xiangqian Huang Xiaoming Zhang Jiahao Song Duo Lan Mengqi Wang Xunming Ji Da Zhou Ran Meng |
| author_sort | Xiangqian Huang |
| collection | DOAJ |
| description | Abstract Background and purpose Although Ginkgo biloba extract (GBE) has been shown to be effective in treating acute ischemic stroke (AIS) in several clinical trials, concerns regarding adverse events, such as bleeding, have been raised. This study aimed to investigate the mechanisms by which GBE improves AIS prognosis, particularly its impact on platelet activity, coagulation function, and the potential risk of bleeding. Methods This real-world study consecutively enrolled 99 patients: 49 with internal jugular venous stenosis (IJVS) treated with GBE; 33 with AIS treated with GBE and low-dose aspirin; and 17 with AIS treated with low-dose aspirin alone. Plasma platelet aggregation and coagulation status were assessed before and after treatment. Major and minor bleeding events were recorded in the AIS group. Results In the IJVS group, GBE specifically inhibited arachidonic acid (AA)-induced, but not ADP-induced, platelet aggregation, along with prolonged thrombin time (PT) and activated partial thromboplastin time (APTT). In the AIS group, the combined use of low-dose aspirin and GBE further reduced AA-induced platelet aggregation, mildly prolonged APTT, and was associated with an increased risk of minor bleeding events. Conclusions The therapeutic effect of GBE in AIS may, in part, be attributed to its ability to enhance the antiplatelet action of aspirin, particularly in inhibiting AA-induced platelet aggregation. However, the potential for increased bleeding risk warrants further investigation. |
| format | Article |
| id | doaj-art-811cd147acb94b2291a4045e34e49e86 |
| institution | Kabale University |
| issn | 1477-9560 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj-art-811cd147acb94b2291a4045e34e49e862025-02-09T12:50:53ZengBMCThrombosis Journal1477-95602025-02-0123111010.1186/s12959-025-00696-xThe mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world studyXiangqian Huang0Xiaoming Zhang1Jiahao Song2Duo Lan3Mengqi Wang4Xunming Ji5Da Zhou6Ran Meng7Department of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityAbstract Background and purpose Although Ginkgo biloba extract (GBE) has been shown to be effective in treating acute ischemic stroke (AIS) in several clinical trials, concerns regarding adverse events, such as bleeding, have been raised. This study aimed to investigate the mechanisms by which GBE improves AIS prognosis, particularly its impact on platelet activity, coagulation function, and the potential risk of bleeding. Methods This real-world study consecutively enrolled 99 patients: 49 with internal jugular venous stenosis (IJVS) treated with GBE; 33 with AIS treated with GBE and low-dose aspirin; and 17 with AIS treated with low-dose aspirin alone. Plasma platelet aggregation and coagulation status were assessed before and after treatment. Major and minor bleeding events were recorded in the AIS group. Results In the IJVS group, GBE specifically inhibited arachidonic acid (AA)-induced, but not ADP-induced, platelet aggregation, along with prolonged thrombin time (PT) and activated partial thromboplastin time (APTT). In the AIS group, the combined use of low-dose aspirin and GBE further reduced AA-induced platelet aggregation, mildly prolonged APTT, and was associated with an increased risk of minor bleeding events. Conclusions The therapeutic effect of GBE in AIS may, in part, be attributed to its ability to enhance the antiplatelet action of aspirin, particularly in inhibiting AA-induced platelet aggregation. However, the potential for increased bleeding risk warrants further investigation.https://doi.org/10.1186/s12959-025-00696-xGinkgo biloba extractPlatelet aggregationCoagulation functionBleeding events |
| spellingShingle | Xiangqian Huang Xiaoming Zhang Jiahao Song Duo Lan Mengqi Wang Xunming Ji Da Zhou Ran Meng The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study Thrombosis Journal Ginkgo biloba extract Platelet aggregation Coagulation function Bleeding events |
| title | The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study |
| title_full | The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study |
| title_fullStr | The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study |
| title_full_unstemmed | The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study |
| title_short | The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study |
| title_sort | mechanisms of efficacy and safety of ginkgo biloba extract in acute ischemic stroke a real world study |
| topic | Ginkgo biloba extract Platelet aggregation Coagulation function Bleeding events |
| url | https://doi.org/10.1186/s12959-025-00696-x |
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