Impact of leachate from boiled-water-treated plastic products on male reproductive health: Insights from transcriptomic and metabolomic profiling
Given the extensive use of plastic materials in modern society, there is an escalating concern about the potential risks associated with exposure to plastic products. This study investigated the impact of plastic leachates from boiled-water-treated cups, including polypropylene (PP), high-density po...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000843 |
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| author | Xinghua Yu Rui Yao Ge Meng Lingan Zeng Leyi Zhou Yingkang Shen Amali Upekshika Wijayaraja Reshmi Hareendra Kariyapperuma Wentao Xu Yuxiang Mei Xinyan Gu Wen-Long Lei Pengfei Zhang Fei Sun |
| author_facet | Xinghua Yu Rui Yao Ge Meng Lingan Zeng Leyi Zhou Yingkang Shen Amali Upekshika Wijayaraja Reshmi Hareendra Kariyapperuma Wentao Xu Yuxiang Mei Xinyan Gu Wen-Long Lei Pengfei Zhang Fei Sun |
| author_sort | Xinghua Yu |
| collection | DOAJ |
| description | Given the extensive use of plastic materials in modern society, there is an escalating concern about the potential risks associated with exposure to plastic products. This study investigated the impact of plastic leachates from boiled-water-treated cups, including polypropylene (PP), high-density polyethylene (HDPE), low-density polyethylene (LDPE), polystyrene (PS), and polyethylene terephthalate (PET), on male reproductive health. Experimental mice were administered daily doses of the plastic leachates for 180 consecutive days. Histological analysis of the testes and epididymis was conducted, revealing vacuolization and absence of sperms in the seminiferous tubules of mice treated with PP, HDPE, LDPE, and PS, while PET exhibited lower reproductive toxicity. Furthermore, transcriptomic and metabolomic profiling were employed to identify key genes and metabolites related to plastic exposure. Transcriptome analysis showed significant changes in genes associated with spermatogenesis following exposure to leachates, while metabolome analysis indicated an impact on the lipid metabolism pathway. Overall, the study provides evidence that oral exposure to leachates from boiled-water-treated plastic cups could negatively affect spermatogenesis and lipid metabolism, thereby posing risks to male reproductive health. These findings offer crucial insights into the potential risks associated with plastic consumption and may advocate for the selection of relatively safe plastic cups for everyday use. |
| format | Article |
| id | doaj-art-81de3ee97d274c71a027d024460b84cc |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-81de3ee97d274c71a027d024460b84cc2025-02-12T05:30:11ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117748Impact of leachate from boiled-water-treated plastic products on male reproductive health: Insights from transcriptomic and metabolomic profilingXinghua Yu0Rui Yao1Ge Meng2Lingan Zeng3Leyi Zhou4Yingkang Shen5Amali Upekshika Wijayaraja6Reshmi Hareendra Kariyapperuma7Wentao Xu8Yuxiang Mei9Xinyan Gu10Wen-Long Lei11Pengfei Zhang12Fei Sun13Department of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China; Corresponding authors.School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang 325037, ChinaDepartment of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, ChinaDepartment of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, ChinaDepartment of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, ChinaDepartment of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, ChinaDepartment of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, ChinaDepartment of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, ChinaDepartment of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, ChinaDepartment of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, ChinaDepartment of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, ChinaDepartment of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, ChinaGuangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaDepartment of Urology & Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China; Corresponding authors.Given the extensive use of plastic materials in modern society, there is an escalating concern about the potential risks associated with exposure to plastic products. This study investigated the impact of plastic leachates from boiled-water-treated cups, including polypropylene (PP), high-density polyethylene (HDPE), low-density polyethylene (LDPE), polystyrene (PS), and polyethylene terephthalate (PET), on male reproductive health. Experimental mice were administered daily doses of the plastic leachates for 180 consecutive days. Histological analysis of the testes and epididymis was conducted, revealing vacuolization and absence of sperms in the seminiferous tubules of mice treated with PP, HDPE, LDPE, and PS, while PET exhibited lower reproductive toxicity. Furthermore, transcriptomic and metabolomic profiling were employed to identify key genes and metabolites related to plastic exposure. Transcriptome analysis showed significant changes in genes associated with spermatogenesis following exposure to leachates, while metabolome analysis indicated an impact on the lipid metabolism pathway. Overall, the study provides evidence that oral exposure to leachates from boiled-water-treated plastic cups could negatively affect spermatogenesis and lipid metabolism, thereby posing risks to male reproductive health. These findings offer crucial insights into the potential risks associated with plastic consumption and may advocate for the selection of relatively safe plastic cups for everyday use.http://www.sciencedirect.com/science/article/pii/S0147651325000843Plastic cupsMale reproductive healthLeachateTranscriptomicsMetabolomics |
| spellingShingle | Xinghua Yu Rui Yao Ge Meng Lingan Zeng Leyi Zhou Yingkang Shen Amali Upekshika Wijayaraja Reshmi Hareendra Kariyapperuma Wentao Xu Yuxiang Mei Xinyan Gu Wen-Long Lei Pengfei Zhang Fei Sun Impact of leachate from boiled-water-treated plastic products on male reproductive health: Insights from transcriptomic and metabolomic profiling Ecotoxicology and Environmental Safety Plastic cups Male reproductive health Leachate Transcriptomics Metabolomics |
| title | Impact of leachate from boiled-water-treated plastic products on male reproductive health: Insights from transcriptomic and metabolomic profiling |
| title_full | Impact of leachate from boiled-water-treated plastic products on male reproductive health: Insights from transcriptomic and metabolomic profiling |
| title_fullStr | Impact of leachate from boiled-water-treated plastic products on male reproductive health: Insights from transcriptomic and metabolomic profiling |
| title_full_unstemmed | Impact of leachate from boiled-water-treated plastic products on male reproductive health: Insights from transcriptomic and metabolomic profiling |
| title_short | Impact of leachate from boiled-water-treated plastic products on male reproductive health: Insights from transcriptomic and metabolomic profiling |
| title_sort | impact of leachate from boiled water treated plastic products on male reproductive health insights from transcriptomic and metabolomic profiling |
| topic | Plastic cups Male reproductive health Leachate Transcriptomics Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000843 |
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