Compliant immune response of silk-based biomaterials broadens application in wound treatment
The unique properties of sericin and silk fibroin (SF) favor their widespread application in biopharmaceuticals, particularly in wound treatment and bone repair. The immune response directly influences wound healing cycle, and the extensive immunomodulatory functions of silk-based nanoparticles and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1548837/full |
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| author | Zhiqiang Tian Hong Chen Ping Zhao |
| author_facet | Zhiqiang Tian Hong Chen Ping Zhao |
| author_sort | Zhiqiang Tian |
| collection | DOAJ |
| description | The unique properties of sericin and silk fibroin (SF) favor their widespread application in biopharmaceuticals, particularly in wound treatment and bone repair. The immune response directly influences wound healing cycle, and the extensive immunomodulatory functions of silk-based nanoparticles and hydrogels have attracted wide attention. However, different silk-processing methods may trigger intense immune system resistance after implantation into the body. In this review, we elaborate on the inflammation and immune responses caused by the implantation of sericin and SF and also explore their anti-inflammatory properties and immune regulatory functions. More importantly, we describe the latest research progress in enhancing the immunotherapeutic and anti-inflammatory effects of composite materials prepared from silk from a mechanistic perspective. This review will provide a useful reference for using the correct processes to exploit silk-based biomaterials in different wound treatments. |
| format | Article |
| id | doaj-art-821e9159226f4387aca1c1a8d74c7426 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-821e9159226f4387aca1c1a8d74c74262025-02-12T07:26:40ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.15488371548837Compliant immune response of silk-based biomaterials broadens application in wound treatmentZhiqiang Tian0Hong Chen1Ping Zhao2Biological Science Research Center, Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Southwest University, Chongqing, ChinaDepartment of Orthopedics, 903 Hospital of Joint Logistic Support Force of The People’s Liberation Army, Hangzhou, ChinaBiological Science Research Center, Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Southwest University, Chongqing, ChinaThe unique properties of sericin and silk fibroin (SF) favor their widespread application in biopharmaceuticals, particularly in wound treatment and bone repair. The immune response directly influences wound healing cycle, and the extensive immunomodulatory functions of silk-based nanoparticles and hydrogels have attracted wide attention. However, different silk-processing methods may trigger intense immune system resistance after implantation into the body. In this review, we elaborate on the inflammation and immune responses caused by the implantation of sericin and SF and also explore their anti-inflammatory properties and immune regulatory functions. More importantly, we describe the latest research progress in enhancing the immunotherapeutic and anti-inflammatory effects of composite materials prepared from silk from a mechanistic perspective. This review will provide a useful reference for using the correct processes to exploit silk-based biomaterials in different wound treatments.https://www.frontiersin.org/articles/10.3389/fphar.2025.1548837/fullbiopharmaceuticalsnanomedicinesericinsilk fibroin (SF)wound treatment |
| spellingShingle | Zhiqiang Tian Hong Chen Ping Zhao Compliant immune response of silk-based biomaterials broadens application in wound treatment Frontiers in Pharmacology biopharmaceuticals nanomedicine sericin silk fibroin (SF) wound treatment |
| title | Compliant immune response of silk-based biomaterials broadens application in wound treatment |
| title_full | Compliant immune response of silk-based biomaterials broadens application in wound treatment |
| title_fullStr | Compliant immune response of silk-based biomaterials broadens application in wound treatment |
| title_full_unstemmed | Compliant immune response of silk-based biomaterials broadens application in wound treatment |
| title_short | Compliant immune response of silk-based biomaterials broadens application in wound treatment |
| title_sort | compliant immune response of silk based biomaterials broadens application in wound treatment |
| topic | biopharmaceuticals nanomedicine sericin silk fibroin (SF) wound treatment |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1548837/full |
| work_keys_str_mv | AT zhiqiangtian compliantimmuneresponseofsilkbasedbiomaterialsbroadensapplicationinwoundtreatment AT hongchen compliantimmuneresponseofsilkbasedbiomaterialsbroadensapplicationinwoundtreatment AT pingzhao compliantimmuneresponseofsilkbasedbiomaterialsbroadensapplicationinwoundtreatment |