Assessment of serum survivin in women with placenta previa and accreta spectrum: a cross-sectional study
Abstract This study aimed to examine the relationship between maternal serum survivin levels and placental disorders by comparing these levels across cases of normal placentation, placenta previa, and placenta accreta spectrum (PAS). In this prospective cross-sectional study, we enrolled 84 pregnant...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-89384-4 |
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| author | Nevin Yilmaz Isil Turan Bakirci Busra Sahin Gokhan Bolluk Esra Can Huri Dedeakayogullari |
| author_facet | Nevin Yilmaz Isil Turan Bakirci Busra Sahin Gokhan Bolluk Esra Can Huri Dedeakayogullari |
| author_sort | Nevin Yilmaz |
| collection | DOAJ |
| description | Abstract This study aimed to examine the relationship between maternal serum survivin levels and placental disorders by comparing these levels across cases of normal placentation, placenta previa, and placenta accreta spectrum (PAS). In this prospective cross-sectional study, we enrolled 84 pregnant women categorized into control (n = 42), placenta previa (n = 24), and PAS (n = 28) groups. Serum survivin levels were quantitatively determined using ELISA, and statistical analyses were performed using ANOVA and post-hoc tests. Serum survivin levels were significantly elevated in the placenta previa (348.3 pg/mL, range: 173.0-776.4) and PAS groups (785 pg/mL, range: 324.50–1122) compared to controls (177.9 pg/mL, range: 87.3–242.0) (p < 0.05), suggesting an association between survivin expression and abnormal placental adherence and invasion. Our findings demonstrate significant associations between elevated serum survivin levels and placental disorders, specifically placenta previa and PAS. These associations suggest a potential role for survivin in the pathogenesis of placental complications and warrant further investigation through longitudinal studies. |
| format | Article |
| id | doaj-art-831e81130ea3411e8e40578000fb09d9 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-831e81130ea3411e8e40578000fb09d92025-02-09T12:30:14ZengNature PortfolioScientific Reports2045-23222025-02-011511710.1038/s41598-025-89384-4Assessment of serum survivin in women with placenta previa and accreta spectrum: a cross-sectional studyNevin Yilmaz0Isil Turan Bakirci1Busra Sahin2Gokhan Bolluk3Esra Can4Huri Dedeakayogullari5Department of Obstetrics and Gynecology, Kanuni Sultan Suleyman Training and Research Hospital, Health Sciences UniversityDepartment of Perinatology, Basaksehir Cam and Sakura City Hospital, Health Sciences UniversityPrivate Ordu Sevgi HospitalDepartment of Perinatology, Basaksehir Cam and Sakura City Hospital, Health Sciences UniversityDepartment of Obstetrics and Gynecology, Kanuni Sultan Suleyman Training and Research Hospital, Health Sciences UniversityDepartment of Medical Biochemistry, Faculty of Medicine, Biruni UniversityAbstract This study aimed to examine the relationship between maternal serum survivin levels and placental disorders by comparing these levels across cases of normal placentation, placenta previa, and placenta accreta spectrum (PAS). In this prospective cross-sectional study, we enrolled 84 pregnant women categorized into control (n = 42), placenta previa (n = 24), and PAS (n = 28) groups. Serum survivin levels were quantitatively determined using ELISA, and statistical analyses were performed using ANOVA and post-hoc tests. Serum survivin levels were significantly elevated in the placenta previa (348.3 pg/mL, range: 173.0-776.4) and PAS groups (785 pg/mL, range: 324.50–1122) compared to controls (177.9 pg/mL, range: 87.3–242.0) (p < 0.05), suggesting an association between survivin expression and abnormal placental adherence and invasion. Our findings demonstrate significant associations between elevated serum survivin levels and placental disorders, specifically placenta previa and PAS. These associations suggest a potential role for survivin in the pathogenesis of placental complications and warrant further investigation through longitudinal studies.https://doi.org/10.1038/s41598-025-89384-4Placenta previaPlacenta accreta spectrumSurvivin |
| spellingShingle | Nevin Yilmaz Isil Turan Bakirci Busra Sahin Gokhan Bolluk Esra Can Huri Dedeakayogullari Assessment of serum survivin in women with placenta previa and accreta spectrum: a cross-sectional study Scientific Reports Placenta previa Placenta accreta spectrum Survivin |
| title | Assessment of serum survivin in women with placenta previa and accreta spectrum: a cross-sectional study |
| title_full | Assessment of serum survivin in women with placenta previa and accreta spectrum: a cross-sectional study |
| title_fullStr | Assessment of serum survivin in women with placenta previa and accreta spectrum: a cross-sectional study |
| title_full_unstemmed | Assessment of serum survivin in women with placenta previa and accreta spectrum: a cross-sectional study |
| title_short | Assessment of serum survivin in women with placenta previa and accreta spectrum: a cross-sectional study |
| title_sort | assessment of serum survivin in women with placenta previa and accreta spectrum a cross sectional study |
| topic | Placenta previa Placenta accreta spectrum Survivin |
| url | https://doi.org/10.1038/s41598-025-89384-4 |
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