In vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systems
The benefit of complex 3D models to facilitate the robust testing of new drugs and drug delivery systems during the developmental stages of pharmaceutical manufacturing has recently become distinguished within the field. Recognition of this need by the pharmaceutical industry has provided a motivati...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-02-01
|
| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/20417314241313458 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825197102473412608 |
|---|---|
| author | Robyn A Macartney Abijit Das Atina G Imaniyyah Annabelle TR Fricker Andrew M Smith Stefano Fedele Ipsita Roy Hae-Won Kim Dongjoon Lee Jonathan C Knowles |
| author_facet | Robyn A Macartney Abijit Das Atina G Imaniyyah Annabelle TR Fricker Andrew M Smith Stefano Fedele Ipsita Roy Hae-Won Kim Dongjoon Lee Jonathan C Knowles |
| author_sort | Robyn A Macartney |
| collection | DOAJ |
| description | The benefit of complex 3D models to facilitate the robust testing of new drugs and drug delivery systems during the developmental stages of pharmaceutical manufacturing has recently become distinguished within the field. Recognition of this need by the pharmaceutical industry has provided a motivation for research into the development of reliable complex models for use in drug delivery, biomaterials, and tissue engineering. Both 3D in vitro and ex vivo models can enhance drug-testing and discovery prospects over the more traditionally used 2D, monolayer culture systems and animal models. Despite the widespread acceptance that 3D tissue modelling is advantageous in this field, there remains a lack of standardisation in the models throughout literature. This article provides an extensive review of current literature on in vitro, and ex vivo models of the oral mucosa for drug delivery applications; the advantages, limitations, and recommendations for future development of improved models for this application. |
| format | Article |
| id | doaj-art-83912deecb434b9180ebe53c259e4346 |
| institution | Kabale University |
| issn | 2041-7314 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj-art-83912deecb434b9180ebe53c259e43462025-02-11T20:03:28ZengSAGE PublishingJournal of Tissue Engineering2041-73142025-02-011610.1177/20417314241313458In vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systemsRobyn A Macartney0Abijit Das1Atina G Imaniyyah2Annabelle TR Fricker3Andrew M Smith4Stefano Fedele5Ipsita Roy6Hae-Won Kim7Dongjoon Lee8Jonathan C Knowles9Division of Biomaterials and Tissue Engineering, University College London (UCL) Eastman Dental Institute, London, UKDepartment of Nanobiomedical Science &BK12 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of KoreaDivision of Biomaterials and Tissue Engineering, University College London (UCL) Eastman Dental Institute, London, UKSchool of Chemical, Materials & Biological Engineering, Faculty of Engineering, University of Sheffield, Sheffield, UKDepartment of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UKUCL Eastman Dental Institute, University College London, London, UKInsigneo Institute for in silico Medicine, University of Sheffield, UKCollege of Dentistry, Dankook University, Cheonan, Republic of KoreaCollege of Dentistry, Dankook University, Cheonan, Republic of KoreaDepartment of Nanobiomedical Science &BK12 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of KoreaThe benefit of complex 3D models to facilitate the robust testing of new drugs and drug delivery systems during the developmental stages of pharmaceutical manufacturing has recently become distinguished within the field. Recognition of this need by the pharmaceutical industry has provided a motivation for research into the development of reliable complex models for use in drug delivery, biomaterials, and tissue engineering. Both 3D in vitro and ex vivo models can enhance drug-testing and discovery prospects over the more traditionally used 2D, monolayer culture systems and animal models. Despite the widespread acceptance that 3D tissue modelling is advantageous in this field, there remains a lack of standardisation in the models throughout literature. This article provides an extensive review of current literature on in vitro, and ex vivo models of the oral mucosa for drug delivery applications; the advantages, limitations, and recommendations for future development of improved models for this application.https://doi.org/10.1177/20417314241313458 |
| spellingShingle | Robyn A Macartney Abijit Das Atina G Imaniyyah Annabelle TR Fricker Andrew M Smith Stefano Fedele Ipsita Roy Hae-Won Kim Dongjoon Lee Jonathan C Knowles In vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systems Journal of Tissue Engineering |
| title | In vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systems |
| title_full | In vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systems |
| title_fullStr | In vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systems |
| title_full_unstemmed | In vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systems |
| title_short | In vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systems |
| title_sort | in vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systems |
| url | https://doi.org/10.1177/20417314241313458 |
| work_keys_str_mv | AT robynamacartney invitroandexvivomodelsoftheoralmucosaasplatformsforthevalidationofnoveldrugdeliverysystems AT abijitdas invitroandexvivomodelsoftheoralmucosaasplatformsforthevalidationofnoveldrugdeliverysystems AT atinagimaniyyah invitroandexvivomodelsoftheoralmucosaasplatformsforthevalidationofnoveldrugdeliverysystems AT annabelletrfricker invitroandexvivomodelsoftheoralmucosaasplatformsforthevalidationofnoveldrugdeliverysystems AT andrewmsmith invitroandexvivomodelsoftheoralmucosaasplatformsforthevalidationofnoveldrugdeliverysystems AT stefanofedele invitroandexvivomodelsoftheoralmucosaasplatformsforthevalidationofnoveldrugdeliverysystems AT ipsitaroy invitroandexvivomodelsoftheoralmucosaasplatformsforthevalidationofnoveldrugdeliverysystems AT haewonkim invitroandexvivomodelsoftheoralmucosaasplatformsforthevalidationofnoveldrugdeliverysystems AT dongjoonlee invitroandexvivomodelsoftheoralmucosaasplatformsforthevalidationofnoveldrugdeliverysystems AT jonathancknowles invitroandexvivomodelsoftheoralmucosaasplatformsforthevalidationofnoveldrugdeliverysystems |