Generalized pustular psoriasis: a multicentric study on patient characteristics and clinical burden
Abstract The objective of this study was to assess the demographic characteristics and impact on quality of life (QoL) of patients with PPG in France through a multicentre study. The results of the study are as follows: The PRO [PUSH-D, PHQ-9 et GAD-7] revealed that more than half of the patients ex...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Orphanet Journal of Rare Diseases |
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| Online Access: | https://doi.org/10.1186/s13023-025-03559-w |
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| author | Cristina Bulai Livideanu Jérémy Gottlieb Denis Jullien Thierry Passeron Sophie Vildy Emmanuel Delaporte Carle Paul Julien Chollet Marie Najean Denis San Charles Taieb Bénédicte Charles Emmanuel Mahe Pierre-André Becherel Laurent Misery |
| author_facet | Cristina Bulai Livideanu Jérémy Gottlieb Denis Jullien Thierry Passeron Sophie Vildy Emmanuel Delaporte Carle Paul Julien Chollet Marie Najean Denis San Charles Taieb Bénédicte Charles Emmanuel Mahe Pierre-André Becherel Laurent Misery |
| author_sort | Cristina Bulai Livideanu |
| collection | DOAJ |
| description | Abstract The objective of this study was to assess the demographic characteristics and impact on quality of life (QoL) of patients with PPG in France through a multicentre study. The results of the study are as follows: The PRO [PUSH-D, PHQ-9 et GAD-7] revealed that more than half of the patients exhibited a significant impact on their quality of life. High scores for fatigue, stress, skin and joint pain were reported, with 65% of patients at risk of mild to severe depression. The clinical burden was also assessed. A total of 48.8% of patients were hospitalised, while 39% took sick leave. This study is the first to assess the PUSH-D, PHQ-9 and GAD-7 scores in patients with PPG, which highlighted a significant clinical burden and negative impact on their daily lives. |
| format | Article |
| id | doaj-art-83bcd7a637e44875ab49f041a937c16d |
| institution | Kabale University |
| issn | 1750-1172 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Orphanet Journal of Rare Diseases |
| spelling | doaj-art-83bcd7a637e44875ab49f041a937c16d2025-02-09T12:54:08ZengBMCOrphanet Journal of Rare Diseases1750-11722025-02-012011410.1186/s13023-025-03559-wGeneralized pustular psoriasis: a multicentric study on patient characteristics and clinical burdenCristina Bulai Livideanu0Jérémy Gottlieb1Denis Jullien2Thierry Passeron3Sophie Vildy4Emmanuel Delaporte5Carle Paul6Julien Chollet7Marie Najean8Denis San9Charles Taieb10Bénédicte Charles11Emmanuel Mahe12Pierre-André Becherel13Laurent Misery14Department of Dermatology, Hôpital Larrey, Toulouse University HospitalDepartment of DermatologyDepartment of Dermatology, Faculty of Medicine Lyon-Est, Hôpital Edouard Herriot, University of LyonDepartment of Dermatology, Université Côte D’Azur, Centre Hospitalier Universitaire NiceDepartment of Dermatology, Hôpital privé du ConfluentDepartment of Dermatology, Aix Marseille University, APHM, North HospitalDepartment of DermatologyBoehringer Ingelheim FranceBoehringer Ingelheim FranceBoehringer Ingelheim FrancePatients priority, EMMAFrance psoriasisDepartment of Dermatology, Hôpital Victor DupouyDermatology Department, Private Hospital AntonyUniv Brest, LIENAbstract The objective of this study was to assess the demographic characteristics and impact on quality of life (QoL) of patients with PPG in France through a multicentre study. The results of the study are as follows: The PRO [PUSH-D, PHQ-9 et GAD-7] revealed that more than half of the patients exhibited a significant impact on their quality of life. High scores for fatigue, stress, skin and joint pain were reported, with 65% of patients at risk of mild to severe depression. The clinical burden was also assessed. A total of 48.8% of patients were hospitalised, while 39% took sick leave. This study is the first to assess the PUSH-D, PHQ-9 and GAD-7 scores in patients with PPG, which highlighted a significant clinical burden and negative impact on their daily lives.https://doi.org/10.1186/s13023-025-03559-wGeneralized Pustular PsoriasisBurdenQuality of lifeStigmatization |
| spellingShingle | Cristina Bulai Livideanu Jérémy Gottlieb Denis Jullien Thierry Passeron Sophie Vildy Emmanuel Delaporte Carle Paul Julien Chollet Marie Najean Denis San Charles Taieb Bénédicte Charles Emmanuel Mahe Pierre-André Becherel Laurent Misery Generalized pustular psoriasis: a multicentric study on patient characteristics and clinical burden Orphanet Journal of Rare Diseases Generalized Pustular Psoriasis Burden Quality of life Stigmatization |
| title | Generalized pustular psoriasis: a multicentric study on patient characteristics and clinical burden |
| title_full | Generalized pustular psoriasis: a multicentric study on patient characteristics and clinical burden |
| title_fullStr | Generalized pustular psoriasis: a multicentric study on patient characteristics and clinical burden |
| title_full_unstemmed | Generalized pustular psoriasis: a multicentric study on patient characteristics and clinical burden |
| title_short | Generalized pustular psoriasis: a multicentric study on patient characteristics and clinical burden |
| title_sort | generalized pustular psoriasis a multicentric study on patient characteristics and clinical burden |
| topic | Generalized Pustular Psoriasis Burden Quality of life Stigmatization |
| url | https://doi.org/10.1186/s13023-025-03559-w |
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