MAIT cells protect against sterile lung injury
Summary: Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, can exhibit a wide range of functional responses to different triggers via their T cell receptor (TCR) and/or cytokines. Their role, especially in sterile lung injury, is unknown. Using single...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725000464 |
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| author | Xiawei Zhang Shuailin Li Wojciech Lason Maria Greco Paul Klenerman Timothy S.C. Hinks |
| author_facet | Xiawei Zhang Shuailin Li Wojciech Lason Maria Greco Paul Klenerman Timothy S.C. Hinks |
| author_sort | Xiawei Zhang |
| collection | DOAJ |
| description | Summary: Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, can exhibit a wide range of functional responses to different triggers via their T cell receptor (TCR) and/or cytokines. Their role, especially in sterile lung injury, is unknown. Using single-cell RNA sequencing (scRNA-seq), spectral analysis, and adoptive transfer in a bleomycin-induced sterile lung injury, we found that bleomycin activates murine pulmonary MAIT cells and is associated with a protective role against bleomycin-induced lung injury. MAIT cells drive the accumulation of type 1 conventional dendritic cells (cDC1s), limiting tissue damage in a DNGR-1-dependent manner. Human scRNA-seq data revealed that MAIT cells were activated, with increased cDC populations in idiopathic pulmonary fibrosis patients. Thus, MAIT cells enhance defense against sterile lung injury by fostering cDC1-driven anti-fibrotic pathways. |
| format | Article |
| id | doaj-art-84c98481bb944e37885d3bc0d727a52f |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-84c98481bb944e37885d3bc0d727a52f2025-02-08T05:00:10ZengElsevierCell Reports2211-12472025-02-01442115275MAIT cells protect against sterile lung injuryXiawei Zhang0Shuailin Li1Wojciech Lason2Maria Greco3Paul Klenerman4Timothy S.C. Hinks5Respiratory Medicine Unit, Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UKJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UKRespiratory Medicine Unit, Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UKMRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UKPeter Medawar Building for Pathogen Research and Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX1 3SY, UKRespiratory Medicine Unit, Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK; Corresponding authorSummary: Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, can exhibit a wide range of functional responses to different triggers via their T cell receptor (TCR) and/or cytokines. Their role, especially in sterile lung injury, is unknown. Using single-cell RNA sequencing (scRNA-seq), spectral analysis, and adoptive transfer in a bleomycin-induced sterile lung injury, we found that bleomycin activates murine pulmonary MAIT cells and is associated with a protective role against bleomycin-induced lung injury. MAIT cells drive the accumulation of type 1 conventional dendritic cells (cDC1s), limiting tissue damage in a DNGR-1-dependent manner. Human scRNA-seq data revealed that MAIT cells were activated, with increased cDC populations in idiopathic pulmonary fibrosis patients. Thus, MAIT cells enhance defense against sterile lung injury by fostering cDC1-driven anti-fibrotic pathways.http://www.sciencedirect.com/science/article/pii/S2211124725000464CP: Immunology |
| spellingShingle | Xiawei Zhang Shuailin Li Wojciech Lason Maria Greco Paul Klenerman Timothy S.C. Hinks MAIT cells protect against sterile lung injury Cell Reports CP: Immunology |
| title | MAIT cells protect against sterile lung injury |
| title_full | MAIT cells protect against sterile lung injury |
| title_fullStr | MAIT cells protect against sterile lung injury |
| title_full_unstemmed | MAIT cells protect against sterile lung injury |
| title_short | MAIT cells protect against sterile lung injury |
| title_sort | mait cells protect against sterile lung injury |
| topic | CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725000464 |
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