Clinical role of endothelial dysfunction and hemostasis gene allelic variants in hepatitis C virus-associated cryoglobulinemia
Aim of investigation. To estimate the effect of carriage of endothelial dysfunction and hemostasis gene allelic variants on development of cryoglobulinemic vasculitis (CryoVas) and its clinical symptoms in patients with chronic hepatitis C (CHC). Material and methods. Original study included overall...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/215 |
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| author | M. V. Sokolova Ye. Ye. Starostina T. N. Krasnova L. M. Samokhodskaya T. P. Rozina V. G. Avdeyev M. G. Artemova Ye. B. Yarovaya N. A. Mukhin |
| author_facet | M. V. Sokolova Ye. Ye. Starostina T. N. Krasnova L. M. Samokhodskaya T. P. Rozina V. G. Avdeyev M. G. Artemova Ye. B. Yarovaya N. A. Mukhin |
| author_sort | M. V. Sokolova |
| collection | DOAJ |
| description | Aim of investigation. To estimate the effect of carriage of endothelial dysfunction and hemostasis gene allelic variants on development of cryoglobulinemic vasculitis (CryoVas) and its clinical symptoms in patients with chronic hepatitis C (CHC). Material and methods. Original study included overall 72 patients with CHC and cryoglobulinemia: 21 patients had CryoVas, 51 - CHC without vasculitis. Results. The T allele of NOS3 894 G/T gene was more frequent, T allele of ITGA2 807 C/T gene (OR =0.419) was less common and C allele of ITGB3 1565 T/C gene was more frequent (OR=2.33) in CryoVas patients. Multivariate assay revealed the number of mutant alleles («total score») of NOS3 894 G/T, ITGA2 807 C/T and ITGB3 1565 T/C genes as independent risk factor. The T allele of NOS3 894 G/T gene was found in patients with renal disease significantly less frequently (15% vs 45.5%; р=0.035) as well as in patients with systemic hypertension (30% and 72.7%; р=0.086). Conclusions. Carriage of GT genotype of NOS3 894 G/T gene and CC genotype of ITGB3 1565 T/C gene is associated with high risk of CryoVas development. The TT genotype of ITGA2 807 C/T gene possess «protective» properties. The «total score» is independent predictor of CryoVas development. |
| format | Article |
| id | doaj-art-8549c18d129a479a9f735d7bcb42753c |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-8549c18d129a479a9f735d7bcb42753c2025-02-10T16:14:29ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01281334010.22416/1382-4376-2018-28-1-33-40215Clinical role of endothelial dysfunction and hemostasis gene allelic variants in hepatitis C virus-associated cryoglobulinemiaM. V. Sokolova0Ye. Ye. Starostina1T. N. Krasnova2L. M. Samokhodskaya3T. P. Rozina4V. G. Avdeyev5M. G. Artemova6Ye. B. Yarovaya7N. A. Mukhin8Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»; Federal State Autonomous Educational Institution of Higher Education I.M Sechenov First Moscow State Medical UniversityFederal state educational government-financed institution of higher education «Lomonosov Moscow State University»Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»; Federal State Autonomous Educational Institution of Higher Education I.M Sechenov First Moscow State Medical UniversityFederal state educational government-financed institution of higher education «Lomonosov Moscow State University»; Federal State Autonomous Educational Institution of Higher Education I.M Sechenov First Moscow State Medical UniversityFederal state educational government-financed institution of higher education «Lomonosov Moscow State University»Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»; Federal State Autonomous Educational Institution of Higher Education I.M Sechenov First Moscow State Medical UniversityAim of investigation. To estimate the effect of carriage of endothelial dysfunction and hemostasis gene allelic variants on development of cryoglobulinemic vasculitis (CryoVas) and its clinical symptoms in patients with chronic hepatitis C (CHC). Material and methods. Original study included overall 72 patients with CHC and cryoglobulinemia: 21 patients had CryoVas, 51 - CHC without vasculitis. Results. The T allele of NOS3 894 G/T gene was more frequent, T allele of ITGA2 807 C/T gene (OR =0.419) was less common and C allele of ITGB3 1565 T/C gene was more frequent (OR=2.33) in CryoVas patients. Multivariate assay revealed the number of mutant alleles («total score») of NOS3 894 G/T, ITGA2 807 C/T and ITGB3 1565 T/C genes as independent risk factor. The T allele of NOS3 894 G/T gene was found in patients with renal disease significantly less frequently (15% vs 45.5%; р=0.035) as well as in patients with systemic hypertension (30% and 72.7%; р=0.086). Conclusions. Carriage of GT genotype of NOS3 894 G/T gene and CC genotype of ITGB3 1565 T/C gene is associated with high risk of CryoVas development. The TT genotype of ITGA2 807 C/T gene possess «protective» properties. The «total score» is independent predictor of CryoVas development.https://www.gastro-j.ru/jour/article/view/215хронический гепатит скриоглобулинемический васкулитполиморфизм геновтромбофилиягемостазтромбоцитарные рецепторыэндотелиальная дисфункция |
| spellingShingle | M. V. Sokolova Ye. Ye. Starostina T. N. Krasnova L. M. Samokhodskaya T. P. Rozina V. G. Avdeyev M. G. Artemova Ye. B. Yarovaya N. A. Mukhin Clinical role of endothelial dysfunction and hemostasis gene allelic variants in hepatitis C virus-associated cryoglobulinemia Российский журнал гастроэнтерологии, гепатологии, колопроктологии хронический гепатит с криоглобулинемический васкулит полиморфизм генов тромбофилия гемостаз тромбоцитарные рецепторы эндотелиальная дисфункция |
| title | Clinical role of endothelial dysfunction and hemostasis gene allelic variants in hepatitis C virus-associated cryoglobulinemia |
| title_full | Clinical role of endothelial dysfunction and hemostasis gene allelic variants in hepatitis C virus-associated cryoglobulinemia |
| title_fullStr | Clinical role of endothelial dysfunction and hemostasis gene allelic variants in hepatitis C virus-associated cryoglobulinemia |
| title_full_unstemmed | Clinical role of endothelial dysfunction and hemostasis gene allelic variants in hepatitis C virus-associated cryoglobulinemia |
| title_short | Clinical role of endothelial dysfunction and hemostasis gene allelic variants in hepatitis C virus-associated cryoglobulinemia |
| title_sort | clinical role of endothelial dysfunction and hemostasis gene allelic variants in hepatitis c virus associated cryoglobulinemia |
| topic | хронический гепатит с криоглобулинемический васкулит полиморфизм генов тромбофилия гемостаз тромбоцитарные рецепторы эндотелиальная дисфункция |
| url | https://www.gastro-j.ru/jour/article/view/215 |
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