Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process
Abstract Labelled compounds bearing hydrogen isotopes are keystones in diverse areas constituting a multi-billion dollar global market including drugs, diagnostics, biology, toxicology and smart materials. While hydrogen deuterium exchange (HDE) methods hold promise as relevant tools for the late-st...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56600-8 |
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| author | Kevin Tatoueix Marco Lepron Cédric Barboux Marie-Christine Scherrmann Grégory Pieters Sophie Feuillastre |
| author_facet | Kevin Tatoueix Marco Lepron Cédric Barboux Marie-Christine Scherrmann Grégory Pieters Sophie Feuillastre |
| author_sort | Kevin Tatoueix |
| collection | DOAJ |
| description | Abstract Labelled compounds bearing hydrogen isotopes are keystones in diverse areas constituting a multi-billion dollar global market including drugs, diagnostics, biology, toxicology and smart materials. While hydrogen deuterium exchange (HDE) methods hold promise as relevant tools for the late-stage and one-step preparation of deuterium-labelled compounds, they often fall short in achieving sufficient isotopic purity combined either with a site-selectivity or with a full deuteration process, highlighting the need for further development and optimisation. This report pinpoints an approach to unlock the potential of HDE using the concept of iterative runs in continuous-flow technology (recirculation process). This closed-loop process grants access now to deuterated compounds with high isotopic purities, labelled at a precise site or perdeuterated on demand, in a fast, productive, and environmentally friendly way. |
| format | Article |
| id | doaj-art-85630731057846f49ca5a22e50c3ddc3 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-85630731057846f49ca5a22e50c3ddc32025-02-09T12:45:46ZengNature PortfolioNature Communications2041-17232025-02-011611910.1038/s41467-025-56600-8Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration processKevin Tatoueix0Marco Lepron1Cédric Barboux2Marie-Christine Scherrmann3Grégory Pieters4Sophie Feuillastre5Université Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTSUniversité Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTSUniversité Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTSUniversité Paris-Saclay, CNRS, ICMMOUniversité Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTSUniversité Paris-Saclay, CEA, Service de Chimie Bio-organique et Marquage, DMTSAbstract Labelled compounds bearing hydrogen isotopes are keystones in diverse areas constituting a multi-billion dollar global market including drugs, diagnostics, biology, toxicology and smart materials. While hydrogen deuterium exchange (HDE) methods hold promise as relevant tools for the late-stage and one-step preparation of deuterium-labelled compounds, they often fall short in achieving sufficient isotopic purity combined either with a site-selectivity or with a full deuteration process, highlighting the need for further development and optimisation. This report pinpoints an approach to unlock the potential of HDE using the concept of iterative runs in continuous-flow technology (recirculation process). This closed-loop process grants access now to deuterated compounds with high isotopic purities, labelled at a precise site or perdeuterated on demand, in a fast, productive, and environmentally friendly way.https://doi.org/10.1038/s41467-025-56600-8 |
| spellingShingle | Kevin Tatoueix Marco Lepron Cédric Barboux Marie-Christine Scherrmann Grégory Pieters Sophie Feuillastre Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process Nature Communications |
| title | Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process |
| title_full | Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process |
| title_fullStr | Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process |
| title_full_unstemmed | Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process |
| title_short | Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process |
| title_sort | unlocking the potential of hydrogen deuterium exchange via an iterative continuous flow deuteration process |
| url | https://doi.org/10.1038/s41467-025-56600-8 |
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