DEVELOPMENT, VALIDATION AND KINETIC APPLICATION OFSPECTROMETRIC METHODS FOR THE ANALYSIS OF ASPIRIN, SALICYLICACID, AND CAFFEINE AS SINGLE-COMPONENT AND IN MIXTURES
Aspirin (ASA) and aspirin-caffeine dosage forms are widely used as analgesic drugs. In the present study specific stability-indicating two- and three-component spectrometric methods have been developed for the assay of ASA and its degradation product, salicylic acid, in the presence and absence of...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Baqai University Press
2024-10-01
|
| Series: | Baqai Journal of Health Sciences |
| Online Access: | https://journals.baqai.edu.pk/index.php/CS/article/view/94 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825197177848201216 |
|---|---|
| author | Aqeela Khurshid et al |
| author_facet | Aqeela Khurshid et al |
| author_sort | Aqeela Khurshid et al |
| collection | DOAJ |
| description |
Aspirin (ASA) and aspirin-caffeine dosage forms are widely used as analgesic drugs. In the present
study specific stability-indicating two- and three-component spectrometric methods have been developed
for the assay of ASA and its degradation product, salicylic acid, in the presence and absence of caffeine
(CF). The methods have been validated with respect to different parameters such as linearity, range,
accuracy, precision, reproducibility, limit of detection, limit of quantification and specificity. The
results indicated that the proposed methods are linear in the range of 0.00050.005 mg%, highly
accurate (99.0100.1%), precise (<3.0% RSD) and robust (<2.0% RSD). These methods have been
applied for the assay of ASA in its thermally degraded solution and in degraded tablets. The apparent
first-order rate constants (kobs) for the degradation of ASA at pH 8.010.0 in the absence and presence
of CF are in the range of 5.3711.0×103 min1 and 4.9910.30×103 min1, respectively. The accuracy
and specificity of the methods have been confirmed from the linearity of first-order plots around the
assay data for the degradation of ASA. These methods can accurately determine ASA in the presence
of interfering substances.
|
| format | Article |
| id | doaj-art-86d18d8171034b819ec552715375c8bf |
| institution | Kabale University |
| issn | 2312-4423 2312-6884 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Baqai University Press |
| record_format | Article |
| series | Baqai Journal of Health Sciences |
| spelling | doaj-art-86d18d8171034b819ec552715375c8bf2025-02-11T18:45:39ZengBaqai University PressBaqai Journal of Health Sciences2312-44232312-68842024-10-01211DEVELOPMENT, VALIDATION AND KINETIC APPLICATION OFSPECTROMETRIC METHODS FOR THE ANALYSIS OF ASPIRIN, SALICYLICACID, AND CAFFEINE AS SINGLE-COMPONENT AND IN MIXTURESAqeela Khurshid et al Aspirin (ASA) and aspirin-caffeine dosage forms are widely used as analgesic drugs. In the present study specific stability-indicating two- and three-component spectrometric methods have been developed for the assay of ASA and its degradation product, salicylic acid, in the presence and absence of caffeine (CF). The methods have been validated with respect to different parameters such as linearity, range, accuracy, precision, reproducibility, limit of detection, limit of quantification and specificity. The results indicated that the proposed methods are linear in the range of 0.00050.005 mg%, highly accurate (99.0100.1%), precise (<3.0% RSD) and robust (<2.0% RSD). These methods have been applied for the assay of ASA in its thermally degraded solution and in degraded tablets. The apparent first-order rate constants (kobs) for the degradation of ASA at pH 8.010.0 in the absence and presence of CF are in the range of 5.3711.0×103 min1 and 4.9910.30×103 min1, respectively. The accuracy and specificity of the methods have been confirmed from the linearity of first-order plots around the assay data for the degradation of ASA. These methods can accurately determine ASA in the presence of interfering substances. https://journals.baqai.edu.pk/index.php/CS/article/view/94 |
| spellingShingle | Aqeela Khurshid et al DEVELOPMENT, VALIDATION AND KINETIC APPLICATION OFSPECTROMETRIC METHODS FOR THE ANALYSIS OF ASPIRIN, SALICYLICACID, AND CAFFEINE AS SINGLE-COMPONENT AND IN MIXTURES Baqai Journal of Health Sciences |
| title | DEVELOPMENT, VALIDATION AND KINETIC APPLICATION OFSPECTROMETRIC METHODS FOR THE ANALYSIS OF ASPIRIN, SALICYLICACID, AND CAFFEINE AS SINGLE-COMPONENT AND IN MIXTURES |
| title_full | DEVELOPMENT, VALIDATION AND KINETIC APPLICATION OFSPECTROMETRIC METHODS FOR THE ANALYSIS OF ASPIRIN, SALICYLICACID, AND CAFFEINE AS SINGLE-COMPONENT AND IN MIXTURES |
| title_fullStr | DEVELOPMENT, VALIDATION AND KINETIC APPLICATION OFSPECTROMETRIC METHODS FOR THE ANALYSIS OF ASPIRIN, SALICYLICACID, AND CAFFEINE AS SINGLE-COMPONENT AND IN MIXTURES |
| title_full_unstemmed | DEVELOPMENT, VALIDATION AND KINETIC APPLICATION OFSPECTROMETRIC METHODS FOR THE ANALYSIS OF ASPIRIN, SALICYLICACID, AND CAFFEINE AS SINGLE-COMPONENT AND IN MIXTURES |
| title_short | DEVELOPMENT, VALIDATION AND KINETIC APPLICATION OFSPECTROMETRIC METHODS FOR THE ANALYSIS OF ASPIRIN, SALICYLICACID, AND CAFFEINE AS SINGLE-COMPONENT AND IN MIXTURES |
| title_sort | development validation and kinetic application ofspectrometric methods for the analysis of aspirin salicylicacid and caffeine as single component and in mixtures |
| url | https://journals.baqai.edu.pk/index.php/CS/article/view/94 |
| work_keys_str_mv | AT aqeelakhurshidetal developmentvalidationandkineticapplicationofspectrometricmethodsfortheanalysisofaspirinsalicylicacidandcaffeineassinglecomponentandinmixtures |