Thyroid Dysfunction following Radiotherapy and Combined Therapy in Non-Thyroid Head and Neck Cancers
INTRODUCTION: In patients with head and neck cancers thyroid gland bears the brunt in terms of either excision or irradiation resulting in loss of functionality of the gland leading to thyroid dysfunction. The purpose of this study was to evaluate thyroid function following radiotherapy and combine...
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The Association of Otolaryngologists of India, West Bengal
2023-12-01
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| Series: | Bengal Journal of Otolaryngology and Head Neck Surgery |
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| Online Access: | https://bjohns.in/journal23/index.php/bjohns/article/view/30 |
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| author | Rais Ahmad Bhat Om Prakash Shabab Lalit Angurana |
| author_facet | Rais Ahmad Bhat Om Prakash Shabab Lalit Angurana |
| author_sort | Rais Ahmad Bhat |
| collection | DOAJ |
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INTRODUCTION: In patients with head and neck cancers thyroid gland bears the brunt in terms of either excision or irradiation resulting in loss of functionality of the gland leading to thyroid dysfunction. The purpose of this study was to evaluate thyroid function following radiotherapy and combined therapy in non-thyroid head and neck cancers.
MATERIALS AND METHODS: It was a prospective study of 51 patients with head and neck cancers for duration of one year. Thyroid function tests were done before and at the end, 3 months and 6 months following treatment.
RESULTS: Out of 51 patients, 47 (92.15 %) were males and 4 (7.8 %) were females. All the patients received radiation to the neck to a dose of > 50 GY. 36 patients received concurrent chemotherapy and 7 patients underwent surgery. 4 patients were found to have clinical hypothyroidism, 16 patients subclinical hypothyroidism, 1 patient clinical hyperthyroidism and 1 patient subclinical hyperthyroidism. Thus a total of 22 patients developed thyroid dysfunction (P value of 0.001).
CONCLUSION: Recognizing thyroid dysfunction early and treating it prevents thyroid dysfunction related complications. Hence, thyroid function tests should be done routinely during follow-up in head and neck cancer patients receiving radiotherapy.
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| format | Article |
| id | doaj-art-878875bab1dd4db28cbbcaf040050a87 |
| institution | Kabale University |
| issn | 2395-2393 2395-2407 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | The Association of Otolaryngologists of India, West Bengal |
| record_format | Article |
| series | Bengal Journal of Otolaryngology and Head Neck Surgery |
| spelling | doaj-art-878875bab1dd4db28cbbcaf040050a872025-02-11T09:43:43ZengThe Association of Otolaryngologists of India, West BengalBengal Journal of Otolaryngology and Head Neck Surgery2395-23932395-24072023-12-0131210.47210/bjohns.2023.v31i2.921Thyroid Dysfunction following Radiotherapy and Combined Therapy in Non-Thyroid Head and Neck CancersRais Ahmad Bhat0https://orcid.org/0000-0001-6511-0583Om Prakash1Shabab Lalit Angurana2Govt Medical College Jammu, J and K Government Medical College, Jammu, Jammu and Kashmir, India-180001AIIMS Vijaypur Jammu J and K INTRODUCTION: In patients with head and neck cancers thyroid gland bears the brunt in terms of either excision or irradiation resulting in loss of functionality of the gland leading to thyroid dysfunction. The purpose of this study was to evaluate thyroid function following radiotherapy and combined therapy in non-thyroid head and neck cancers. MATERIALS AND METHODS: It was a prospective study of 51 patients with head and neck cancers for duration of one year. Thyroid function tests were done before and at the end, 3 months and 6 months following treatment. RESULTS: Out of 51 patients, 47 (92.15 %) were males and 4 (7.8 %) were females. All the patients received radiation to the neck to a dose of > 50 GY. 36 patients received concurrent chemotherapy and 7 patients underwent surgery. 4 patients were found to have clinical hypothyroidism, 16 patients subclinical hypothyroidism, 1 patient clinical hyperthyroidism and 1 patient subclinical hyperthyroidism. Thus a total of 22 patients developed thyroid dysfunction (P value of 0.001). CONCLUSION: Recognizing thyroid dysfunction early and treating it prevents thyroid dysfunction related complications. Hence, thyroid function tests should be done routinely during follow-up in head and neck cancer patients receiving radiotherapy. https://bjohns.in/journal23/index.php/bjohns/article/view/30Head and Neck cancersthyroid dysfunctionRadiotherapyChemotherapy |
| spellingShingle | Rais Ahmad Bhat Om Prakash Shabab Lalit Angurana Thyroid Dysfunction following Radiotherapy and Combined Therapy in Non-Thyroid Head and Neck Cancers Bengal Journal of Otolaryngology and Head Neck Surgery Head and Neck cancers thyroid dysfunction Radiotherapy Chemotherapy |
| title | Thyroid Dysfunction following Radiotherapy and Combined Therapy in Non-Thyroid Head and Neck Cancers |
| title_full | Thyroid Dysfunction following Radiotherapy and Combined Therapy in Non-Thyroid Head and Neck Cancers |
| title_fullStr | Thyroid Dysfunction following Radiotherapy and Combined Therapy in Non-Thyroid Head and Neck Cancers |
| title_full_unstemmed | Thyroid Dysfunction following Radiotherapy and Combined Therapy in Non-Thyroid Head and Neck Cancers |
| title_short | Thyroid Dysfunction following Radiotherapy and Combined Therapy in Non-Thyroid Head and Neck Cancers |
| title_sort | thyroid dysfunction following radiotherapy and combined therapy in non thyroid head and neck cancers |
| topic | Head and Neck cancers thyroid dysfunction Radiotherapy Chemotherapy |
| url | https://bjohns.in/journal23/index.php/bjohns/article/view/30 |
| work_keys_str_mv | AT raisahmadbhat thyroiddysfunctionfollowingradiotherapyandcombinedtherapyinnonthyroidheadandneckcancers AT omprakash thyroiddysfunctionfollowingradiotherapyandcombinedtherapyinnonthyroidheadandneckcancers AT shabablalitangurana thyroiddysfunctionfollowingradiotherapyandcombinedtherapyinnonthyroidheadandneckcancers |