Sarcopenia, myosteatosis and inflammation are independent prognostic factors of SARS-CoV-2 pneumonia patients admitted to the ICU
Abstract The aims of our study were to assess the correlations between sarcopenia and myosteatosis assessed by CT-scan at T4 and/or L3 levels and inflammation in critically ill COVID patients on ICU admission, and their respective prognostic value on day 90 death (D90-death). It is a retrospective m...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-88914-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823862494013161472 |
|---|---|
| author | Romain Chauvot de Beauchene Bertrand Souweine Benjamin Bonnet Bertrand Evrard Yves Boirie Lucie Cassagnes Claire Dupuis |
| author_facet | Romain Chauvot de Beauchene Bertrand Souweine Benjamin Bonnet Bertrand Evrard Yves Boirie Lucie Cassagnes Claire Dupuis |
| author_sort | Romain Chauvot de Beauchene |
| collection | DOAJ |
| description | Abstract The aims of our study were to assess the correlations between sarcopenia and myosteatosis assessed by CT-scan at T4 and/or L3 levels and inflammation in critically ill COVID patients on ICU admission, and their respective prognostic value on day 90 death (D90-death). It is a retrospective monocentric study. Sarcopenia was defined by skeletal muscle cross sectional surface area (CSA) and myosteatosis by skeletal muscle density (SMD) at L3 and T4 levels. Inflammatory biomarkers were collected on ICU admission. Of the 239 patients, 74 died by D90; 66.6% get sarcopenia on ICU admission. CSA at T4 level was an independent risk factor for D90-death (1.66[1.03; 2.66]; p = 0.04), as were procalcitonin (2.03[1.2; 3.43]; p = 0.01) and IL-6 levels (1.56[0.96; 2.54]; p = 0.07). In addition, we found correlation factors of 0.79 (p < 0.01) between SMD at T4 and L3 levels, and a correlation factor of 0.64 (p < 0.01) between CSA at T4 and L3 levels.These results indicate a poorer prognosis following a decrease in muscle surface area, a decrease in density, and an increase in inflammatory biomarkers such as Il6. It also suggests that incorporating indices of sarcopenia with inflammatory biomarkers may improve prognostic accuracy. |
| format | Article |
| id | doaj-art-88e9bf8516e24e97a14262db89e6d325 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-88e9bf8516e24e97a14262db89e6d3252025-02-09T12:31:23ZengNature PortfolioScientific Reports2045-23222025-02-0115111110.1038/s41598-025-88914-4Sarcopenia, myosteatosis and inflammation are independent prognostic factors of SARS-CoV-2 pneumonia patients admitted to the ICURomain Chauvot de Beauchene0Bertrand Souweine1Benjamin Bonnet2Bertrand Evrard3Yves Boirie4Lucie Cassagnes5Claire Dupuis6Radiology Department, Clermont-Ferrand University hospitalIntensive Care Department, Clermont-Ferrand University HospitalImmunology Department, Clermont-Ferrand University HospitalImmunology Department, Clermont-Ferrand University HospitalClinical nutrition department, Clermont-Ferrand University hospitalRadiology Department, Clermont-Ferrand University hospitalIntensive Care Department, Clermont-Ferrand University HospitalAbstract The aims of our study were to assess the correlations between sarcopenia and myosteatosis assessed by CT-scan at T4 and/or L3 levels and inflammation in critically ill COVID patients on ICU admission, and their respective prognostic value on day 90 death (D90-death). It is a retrospective monocentric study. Sarcopenia was defined by skeletal muscle cross sectional surface area (CSA) and myosteatosis by skeletal muscle density (SMD) at L3 and T4 levels. Inflammatory biomarkers were collected on ICU admission. Of the 239 patients, 74 died by D90; 66.6% get sarcopenia on ICU admission. CSA at T4 level was an independent risk factor for D90-death (1.66[1.03; 2.66]; p = 0.04), as were procalcitonin (2.03[1.2; 3.43]; p = 0.01) and IL-6 levels (1.56[0.96; 2.54]; p = 0.07). In addition, we found correlation factors of 0.79 (p < 0.01) between SMD at T4 and L3 levels, and a correlation factor of 0.64 (p < 0.01) between CSA at T4 and L3 levels.These results indicate a poorer prognosis following a decrease in muscle surface area, a decrease in density, and an increase in inflammatory biomarkers such as Il6. It also suggests that incorporating indices of sarcopenia with inflammatory biomarkers may improve prognostic accuracy.https://doi.org/10.1038/s41598-025-88914-4COVID 19InflammationChest CT-scanSarcopeniaLow muscle massCritical illness |
| spellingShingle | Romain Chauvot de Beauchene Bertrand Souweine Benjamin Bonnet Bertrand Evrard Yves Boirie Lucie Cassagnes Claire Dupuis Sarcopenia, myosteatosis and inflammation are independent prognostic factors of SARS-CoV-2 pneumonia patients admitted to the ICU Scientific Reports COVID 19 Inflammation Chest CT-scan Sarcopenia Low muscle mass Critical illness |
| title | Sarcopenia, myosteatosis and inflammation are independent prognostic factors of SARS-CoV-2 pneumonia patients admitted to the ICU |
| title_full | Sarcopenia, myosteatosis and inflammation are independent prognostic factors of SARS-CoV-2 pneumonia patients admitted to the ICU |
| title_fullStr | Sarcopenia, myosteatosis and inflammation are independent prognostic factors of SARS-CoV-2 pneumonia patients admitted to the ICU |
| title_full_unstemmed | Sarcopenia, myosteatosis and inflammation are independent prognostic factors of SARS-CoV-2 pneumonia patients admitted to the ICU |
| title_short | Sarcopenia, myosteatosis and inflammation are independent prognostic factors of SARS-CoV-2 pneumonia patients admitted to the ICU |
| title_sort | sarcopenia myosteatosis and inflammation are independent prognostic factors of sars cov 2 pneumonia patients admitted to the icu |
| topic | COVID 19 Inflammation Chest CT-scan Sarcopenia Low muscle mass Critical illness |
| url | https://doi.org/10.1038/s41598-025-88914-4 |
| work_keys_str_mv | AT romainchauvotdebeauchene sarcopeniamyosteatosisandinflammationareindependentprognosticfactorsofsarscov2pneumoniapatientsadmittedtotheicu AT bertrandsouweine sarcopeniamyosteatosisandinflammationareindependentprognosticfactorsofsarscov2pneumoniapatientsadmittedtotheicu AT benjaminbonnet sarcopeniamyosteatosisandinflammationareindependentprognosticfactorsofsarscov2pneumoniapatientsadmittedtotheicu AT bertrandevrard sarcopeniamyosteatosisandinflammationareindependentprognosticfactorsofsarscov2pneumoniapatientsadmittedtotheicu AT yvesboirie sarcopeniamyosteatosisandinflammationareindependentprognosticfactorsofsarscov2pneumoniapatientsadmittedtotheicu AT luciecassagnes sarcopeniamyosteatosisandinflammationareindependentprognosticfactorsofsarscov2pneumoniapatientsadmittedtotheicu AT clairedupuis sarcopeniamyosteatosisandinflammationareindependentprognosticfactorsofsarscov2pneumoniapatientsadmittedtotheicu |