Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study
Abstract Background: Lymph node (LN) involvement, as an important prognostic factor in breast cancer (BC) patients, has a crucial role in their therapeutic approach. Consequently, a great desire is to thoroughly assess the patients based on their axillary LN status. The present study evaluated the c...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84115-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823862315966005248 |
|---|---|
| author | Seyed Mohamad Sadegh Mousavi-kiasary Mahdis Bayat Fereshteh Abbasvandi Batoul Khoundabi Fatemeh Mousavi Atieh Akbari Maryam Bagherian Afsoon Zandi Behnam Honarvar Mohammad Esmaeil Akbari |
| author_facet | Seyed Mohamad Sadegh Mousavi-kiasary Mahdis Bayat Fereshteh Abbasvandi Batoul Khoundabi Fatemeh Mousavi Atieh Akbari Maryam Bagherian Afsoon Zandi Behnam Honarvar Mohammad Esmaeil Akbari |
| author_sort | Seyed Mohamad Sadegh Mousavi-kiasary |
| collection | DOAJ |
| description | Abstract Background: Lymph node (LN) involvement, as an important prognostic factor in breast cancer (BC) patients, has a crucial role in their therapeutic approach. Consequently, a great desire is to thoroughly assess the patients based on their axillary LN status. The present study evaluated the characteristics and survival rate of axillary metastatic BC patients in a Tertiary and referral center. Method: The overall survival, disease-free survival, and clinicopathological characteristics of axillary metastatic BC patients referred to the Cancer Research Center in Tehran, Iran, from 1991 to 2022 were assessed retrospectively. We obtained patients’ clinical data from prospectively maintained registries. Result: Among the total 3399 recruited patients, 49.1%, 26.3%,13.1%, and 6.4% were pN0, pN1, pN2 and pN3, respectively. The pN0 group patients showed a significantly lower Hazard Ratio (HR) for DFS and OS compared to others. Moreover, estrogen and progesterone receptors, human epidermal growth factor2, tumor pathology type and tumor grade were prognostic factors of axillary LN status. Accordingly, pN0 patients had a lower recurrence risk than the others (P = 0.01). Conclusion: The axillary lymph node status has been considered as one of the fundamental factors determining the therapeutic strategy and prognosis of BC patients, which has an association with tumor characteristics. Regarding the crucial impact of the LN status on the survival landscape of breast cancer patients, accurate detection of the involved one and close screening follow-up of patients with more metastatic LNs during the surgery have a high value. |
| format | Article |
| id | doaj-art-8a1ae4d0d5ea470b80a6f46fd78cc00a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-8a1ae4d0d5ea470b80a6f46fd78cc00a2025-02-09T12:35:42ZengNature PortfolioScientific Reports2045-23222025-02-0115111310.1038/s41598-024-84115-7Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort studySeyed Mohamad Sadegh Mousavi-kiasary0Mahdis Bayat1Fereshteh Abbasvandi2Batoul Khoundabi3Fatemeh Mousavi4Atieh Akbari5Maryam Bagherian6Afsoon Zandi7Behnam Honarvar8Mohammad Esmaeil Akbari9Health Policy Research Center, Institute of Health, Shiraz University of Medical SciencesCancer Research Center, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical SciencesCancer Research Center, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical SciencesIran Helal Institute of Applied-Science and Technology, Red Crescent Society of IranHealth Policy Research Center, Institute of Health, Shiraz University of Medical SciencesCancer Research Center, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical SciencesDepartment of Hematology and oncology and stem cell transplantation, Firoozgar Hospital, School of Medicine, Iran University of Medical SciencesDepartment of Otolaryngology, Head and Neck Surgery, Taleghani Hospital, Shahid Beheshti University of Medical SciencesHealth Policy Research Center, Institute of Health, Shiraz University of Medical SciencesCancer Research Center, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical SciencesAbstract Background: Lymph node (LN) involvement, as an important prognostic factor in breast cancer (BC) patients, has a crucial role in their therapeutic approach. Consequently, a great desire is to thoroughly assess the patients based on their axillary LN status. The present study evaluated the characteristics and survival rate of axillary metastatic BC patients in a Tertiary and referral center. Method: The overall survival, disease-free survival, and clinicopathological characteristics of axillary metastatic BC patients referred to the Cancer Research Center in Tehran, Iran, from 1991 to 2022 were assessed retrospectively. We obtained patients’ clinical data from prospectively maintained registries. Result: Among the total 3399 recruited patients, 49.1%, 26.3%,13.1%, and 6.4% were pN0, pN1, pN2 and pN3, respectively. The pN0 group patients showed a significantly lower Hazard Ratio (HR) for DFS and OS compared to others. Moreover, estrogen and progesterone receptors, human epidermal growth factor2, tumor pathology type and tumor grade were prognostic factors of axillary LN status. Accordingly, pN0 patients had a lower recurrence risk than the others (P = 0.01). Conclusion: The axillary lymph node status has been considered as one of the fundamental factors determining the therapeutic strategy and prognosis of BC patients, which has an association with tumor characteristics. Regarding the crucial impact of the LN status on the survival landscape of breast cancer patients, accurate detection of the involved one and close screening follow-up of patients with more metastatic LNs during the surgery have a high value.https://doi.org/10.1038/s41598-024-84115-7Breast cancerAxillary lymph nodesDisease-free survivalOverall survival rate |
| spellingShingle | Seyed Mohamad Sadegh Mousavi-kiasary Mahdis Bayat Fereshteh Abbasvandi Batoul Khoundabi Fatemeh Mousavi Atieh Akbari Maryam Bagherian Afsoon Zandi Behnam Honarvar Mohammad Esmaeil Akbari Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study Scientific Reports Breast cancer Axillary lymph nodes Disease-free survival Overall survival rate |
| title | Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study |
| title_full | Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study |
| title_fullStr | Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study |
| title_full_unstemmed | Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study |
| title_short | Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study |
| title_sort | tumor characteristics and survival rate of axillary metastatic breast cancer patients a three decades retrospective cohort study |
| topic | Breast cancer Axillary lymph nodes Disease-free survival Overall survival rate |
| url | https://doi.org/10.1038/s41598-024-84115-7 |
| work_keys_str_mv | AT seyedmohamadsadeghmousavikiasary tumorcharacteristicsandsurvivalrateofaxillarymetastaticbreastcancerpatientsathreedecadesretrospectivecohortstudy AT mahdisbayat tumorcharacteristicsandsurvivalrateofaxillarymetastaticbreastcancerpatientsathreedecadesretrospectivecohortstudy AT fereshtehabbasvandi tumorcharacteristicsandsurvivalrateofaxillarymetastaticbreastcancerpatientsathreedecadesretrospectivecohortstudy AT batoulkhoundabi tumorcharacteristicsandsurvivalrateofaxillarymetastaticbreastcancerpatientsathreedecadesretrospectivecohortstudy AT fatemehmousavi tumorcharacteristicsandsurvivalrateofaxillarymetastaticbreastcancerpatientsathreedecadesretrospectivecohortstudy AT atiehakbari tumorcharacteristicsandsurvivalrateofaxillarymetastaticbreastcancerpatientsathreedecadesretrospectivecohortstudy AT maryambagherian tumorcharacteristicsandsurvivalrateofaxillarymetastaticbreastcancerpatientsathreedecadesretrospectivecohortstudy AT afsoonzandi tumorcharacteristicsandsurvivalrateofaxillarymetastaticbreastcancerpatientsathreedecadesretrospectivecohortstudy AT behnamhonarvar tumorcharacteristicsandsurvivalrateofaxillarymetastaticbreastcancerpatientsathreedecadesretrospectivecohortstudy AT mohammadesmaeilakbari tumorcharacteristicsandsurvivalrateofaxillarymetastaticbreastcancerpatientsathreedecadesretrospectivecohortstudy |