Risk factors associated with degenerative glenohumeral osteoarthritis
Objective Glenohumeral (GH) osteoarthritis (OA) is the third most common large joint disease, after hip and knee OA. This study aimed to identify risk factors for GH OA.Methods We used data from the Dallas Shoulder cohort, including individuals aged 40–85. Those with confirmed GH OA based on X-ray w...
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BMJ Publishing Group
2025-02-01
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| Series: | BMJ Open Sport & Exercise Medicine |
| Online Access: | https://bmjopensem.bmj.com/content/11/1/e002247.full |
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| author | Ravi Prakash Nitin B Jain Ziyi Chen Folefac D Atem Michael S Khazzam Rashmi Pathak Daniel Tai Ursa BezanPetric Estefanie Garduno Rapp |
| author_facet | Ravi Prakash Nitin B Jain Ziyi Chen Folefac D Atem Michael S Khazzam Rashmi Pathak Daniel Tai Ursa BezanPetric Estefanie Garduno Rapp |
| author_sort | Ravi Prakash |
| collection | DOAJ |
| description | Objective Glenohumeral (GH) osteoarthritis (OA) is the third most common large joint disease, after hip and knee OA. This study aimed to identify risk factors for GH OA.Methods We used data from the Dallas Shoulder cohort, including individuals aged 40–85. Those with confirmed GH OA based on X-ray were cases, and those without were controls. Univariate, least absolute shrinkage and selection operator and multivariate analyses identified risk factors, including age, body mass index (BMI), sex, work-related shoulder problems, shoulder disability, dislocation, previous trauma, surgery, smoking, hypertension, diabetes, depression, heart disease, OA, night pain and overall sleep quality.Results A total of 1827 cases and 1556 controls were identified for GH OA. In univariate analysis, significant associations with GH OA were found for increasing age (>40 to ≤50: OR 3.29, 95% CI 2.44 to 4.45; >50 to ≤60: OR 5.90, 95% CI 4.49 to 7.77; >60 to ≤70: OR 12.18, 95% CI 9.22 to 16.08 and >70: OR 16.54, 95% CI 12.47 to 21.94), higher BMI (≤19: OR 1.44, 95% CI 1.01 to 2.04; >25 to ≤30: OR 1.57, 95% CI 1.32 to 1.86; >30 to ≤35: OR 1.85, 95% CI 1.54 to 2.22 and >35: OR 1.77, 95% CI 1.28 to 2.45), prior shoulder injury (OR 1.30; 95% CI 1.12 to 1.50), shoulder surgery history (OR 0.71; 95% CI 0.57 to 0.87), shoulder pain at night (OR 1.35; 95% CI 1.07 to 1.70) and hypertension (OR 0.70; 95% CI 0.60 to 0.81). In multivariate analysis, significant associations remained for age (>40 to ≤50: OR 2.99, 95% CI 2.21 to 4.06; >50 to ≤60: OR 5.48, 95% CI 4.14 to 7.23; >60 to ≤70: OR 11.22, 95% CI 8.44 to 14.88 and >70: OR 16.65, 95% CI 12.45 to 22.17), BMI (≤19: OR 1.49, 95% CI 1.01 to 2.20; >25 to ≤30: OR 1.45, 95% CI 1.20 to 1.77; >30 to ≤35: OR 1.70, 95% CI 1.39 to 2.09 and >35: OR 1.78, 95% CI 1.25 to 2.55) and previous shoulder trauma (OR 0.80; 95% CI 0.68 to 0.94).Conclusion We identified increasing age and higher BMI as factors associated with GH OA. Due to the large sample size, many risk factors were assessed. Since the shoulder is not a weight-bearing joint, the BMI-GH OA link is likely molecular and systemic, warranting further investigation.Level of evidence Prognostic level III. |
| format | Article |
| id | doaj-art-8b26d17b20a14364929011ebd5c6fb49 |
| institution | Kabale University |
| issn | 2055-7647 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Sport & Exercise Medicine |
| spelling | doaj-art-8b26d17b20a14364929011ebd5c6fb492025-02-07T04:35:10ZengBMJ Publishing GroupBMJ Open Sport & Exercise Medicine2055-76472025-02-0111110.1136/bmjsem-2024-002247Risk factors associated with degenerative glenohumeral osteoarthritisRavi Prakash0Nitin B Jain1Ziyi Chen2Folefac D Atem3Michael S Khazzam4Rashmi Pathak5Daniel Tai6Ursa BezanPetric7Estefanie Garduno Rapp8Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan, USAPM&R and Orthopaedics, University of Michigan-Ann Arbor, Ann Arbor, Michigan, USADepartment of Physical Medicine and Rehabilitation, The University of Texas Southwestern Medical Center, Dallas, Texas, USABiostatistics, University of Texas Southwestern Medical Center, Dallas, Texas, USADepartment of Orthopedic Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USADepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan, USADepartment of Physical Medicine and Rehabilitation, The University of Texas Southwestern Medical Center, Dallas, Texas, USAThe University of Texas Southwestern Medical Center, Dallas, Texas, USADepartment of Physical Medicine and Rehabilitation, The University of Texas Southwestern Medical Center, Dallas, Texas, USAObjective Glenohumeral (GH) osteoarthritis (OA) is the third most common large joint disease, after hip and knee OA. This study aimed to identify risk factors for GH OA.Methods We used data from the Dallas Shoulder cohort, including individuals aged 40–85. Those with confirmed GH OA based on X-ray were cases, and those without were controls. Univariate, least absolute shrinkage and selection operator and multivariate analyses identified risk factors, including age, body mass index (BMI), sex, work-related shoulder problems, shoulder disability, dislocation, previous trauma, surgery, smoking, hypertension, diabetes, depression, heart disease, OA, night pain and overall sleep quality.Results A total of 1827 cases and 1556 controls were identified for GH OA. In univariate analysis, significant associations with GH OA were found for increasing age (>40 to ≤50: OR 3.29, 95% CI 2.44 to 4.45; >50 to ≤60: OR 5.90, 95% CI 4.49 to 7.77; >60 to ≤70: OR 12.18, 95% CI 9.22 to 16.08 and >70: OR 16.54, 95% CI 12.47 to 21.94), higher BMI (≤19: OR 1.44, 95% CI 1.01 to 2.04; >25 to ≤30: OR 1.57, 95% CI 1.32 to 1.86; >30 to ≤35: OR 1.85, 95% CI 1.54 to 2.22 and >35: OR 1.77, 95% CI 1.28 to 2.45), prior shoulder injury (OR 1.30; 95% CI 1.12 to 1.50), shoulder surgery history (OR 0.71; 95% CI 0.57 to 0.87), shoulder pain at night (OR 1.35; 95% CI 1.07 to 1.70) and hypertension (OR 0.70; 95% CI 0.60 to 0.81). In multivariate analysis, significant associations remained for age (>40 to ≤50: OR 2.99, 95% CI 2.21 to 4.06; >50 to ≤60: OR 5.48, 95% CI 4.14 to 7.23; >60 to ≤70: OR 11.22, 95% CI 8.44 to 14.88 and >70: OR 16.65, 95% CI 12.45 to 22.17), BMI (≤19: OR 1.49, 95% CI 1.01 to 2.20; >25 to ≤30: OR 1.45, 95% CI 1.20 to 1.77; >30 to ≤35: OR 1.70, 95% CI 1.39 to 2.09 and >35: OR 1.78, 95% CI 1.25 to 2.55) and previous shoulder trauma (OR 0.80; 95% CI 0.68 to 0.94).Conclusion We identified increasing age and higher BMI as factors associated with GH OA. Due to the large sample size, many risk factors were assessed. Since the shoulder is not a weight-bearing joint, the BMI-GH OA link is likely molecular and systemic, warranting further investigation.Level of evidence Prognostic level III.https://bmjopensem.bmj.com/content/11/1/e002247.full |
| spellingShingle | Ravi Prakash Nitin B Jain Ziyi Chen Folefac D Atem Michael S Khazzam Rashmi Pathak Daniel Tai Ursa BezanPetric Estefanie Garduno Rapp Risk factors associated with degenerative glenohumeral osteoarthritis BMJ Open Sport & Exercise Medicine |
| title | Risk factors associated with degenerative glenohumeral osteoarthritis |
| title_full | Risk factors associated with degenerative glenohumeral osteoarthritis |
| title_fullStr | Risk factors associated with degenerative glenohumeral osteoarthritis |
| title_full_unstemmed | Risk factors associated with degenerative glenohumeral osteoarthritis |
| title_short | Risk factors associated with degenerative glenohumeral osteoarthritis |
| title_sort | risk factors associated with degenerative glenohumeral osteoarthritis |
| url | https://bmjopensem.bmj.com/content/11/1/e002247.full |
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