Gastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tract
The aim of review. To analyze organ-specific features of gastrointestinal myofibroblasts, functional properties, role in embryogenesis and healing of ulcers of gastro-intestinal tract (GIT).Original positions. Morphology, markers, origin and stimulators of development of myofibroblasts, their involv...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2010-06-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1520 |
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| _version_ | 1823860212546666496 |
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| author | E. F. Barinov O. N. Sulayeva |
| author_facet | E. F. Barinov O. N. Sulayeva |
| author_sort | E. F. Barinov |
| collection | DOAJ |
| description | The aim of review. To analyze organ-specific features of gastrointestinal myofibroblasts, functional properties, role in embryogenesis and healing of ulcers of gastro-intestinal tract (GIT).Original positions. Morphology, markers, origin and stimulators of development of myofibroblasts, their involvement in formation of microniche for epithelial stem cells, kinetics of tegmental epithelium, angiogenesis, control of vascular permeability is discussed. Thesefunctions are related to wide spectrum of myofibroblast secretory products, producing molecules of basal membrane, components of matrix and growth factors. Intestinal myofibroblasts are pacemakers for smooth myocytes of GIT, they modulate neurotransmission, participate in modulation of immune response, playing a critical role in reparation of erosions and ulcers of GIT. |
| format | Article |
| id | doaj-art-8caab38ce6274306b4d6976805bb940d |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2010-06-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-8caab38ce6274306b4d6976805bb940d2025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732010-06-012039181037Gastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tractE. F. Barinov0O. N. Sulayeva1Донецкий национальный медицинский университет им. М. ГорькогоДонецкий национальный медицинский университет им. М. ГорькогоThe aim of review. To analyze organ-specific features of gastrointestinal myofibroblasts, functional properties, role in embryogenesis and healing of ulcers of gastro-intestinal tract (GIT).Original positions. Morphology, markers, origin and stimulators of development of myofibroblasts, their involvement in formation of microniche for epithelial stem cells, kinetics of tegmental epithelium, angiogenesis, control of vascular permeability is discussed. Thesefunctions are related to wide spectrum of myofibroblast secretory products, producing molecules of basal membrane, components of matrix and growth factors. Intestinal myofibroblasts are pacemakers for smooth myocytes of GIT, they modulate neurotransmission, participate in modulation of immune response, playing a critical role in reparation of erosions and ulcers of GIT.https://www.gastro-j.ru/jour/article/view/1520myofibroblastsgastro-intestinal tractulcerserosionssecretary products of myofibroblasts |
| spellingShingle | E. F. Barinov O. N. Sulayeva Gastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tract Российский журнал гастроэнтерологии, гепатологии, колопроктологии myofibroblasts gastro-intestinal tract ulcers erosions secretary products of myofibroblasts |
| title | Gastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tract |
| title_full | Gastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tract |
| title_fullStr | Gastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tract |
| title_full_unstemmed | Gastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tract |
| title_short | Gastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tract |
| title_sort | gastrointestinal myofibroblasts role in regulation of physiological activity and reparation of gastro intestinal tract |
| topic | myofibroblasts gastro-intestinal tract ulcers erosions secretary products of myofibroblasts |
| url | https://www.gastro-j.ru/jour/article/view/1520 |
| work_keys_str_mv | AT efbarinov gastrointestinalmyofibroblastsroleinregulationofphysiologicalactivityandreparationofgastrointestinaltract AT onsulayeva gastrointestinalmyofibroblastsroleinregulationofphysiologicalactivityandreparationofgastrointestinaltract |