Clinical Practice Guidelines of the Scientific Society for the Clinical Study of Human Microbiome, of the Russian Gastroenterological Association and the Russian Society for the Prevention of Noncommunicable Diseases on the Diagnosis and Treatment of <i>Clostridioides difficile</i> (<i>C. difficile</i>)-associated Disease in Adults
Аim: the clinical practice guidelines intended for gastroenterologists, internal medicine specialists, infectious disease specialists, general practitioners (family doctors), coloproctologists, surgeons and endoscopists present modern methods of diagnosis, prevention and treatment of C. difficile-as...
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Gastro LLC
2023-09-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/820 |
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| author | V. T. Ivashkin O. S. Lyashenko O. M. Drapkina O. P. Alexeeva S. A. Alekseenko D. N. Andreev A. Yu. Baranovsky O. V. Goloshchapov N. V. Zheleznova O. Yu. Zolnikova I. L. Kliaritskaia N. V. Korochanskaya T. L. Lapina I. V. Maev R. V. Maslennikov R. G. Myazin P. V. Pavlov M. V. Perekalina N. A. Pisarenko A. V. Povtoreyko E. A. Poluektova L. A. Sekretareva A. V. Tkachev Yu. M. Troshkina A. S. Trukhmanov A. I. Ulyanin S. G. Filatova V. V. Tsukanov O. S. Shifrin |
| author_facet | V. T. Ivashkin O. S. Lyashenko O. M. Drapkina O. P. Alexeeva S. A. Alekseenko D. N. Andreev A. Yu. Baranovsky O. V. Goloshchapov N. V. Zheleznova O. Yu. Zolnikova I. L. Kliaritskaia N. V. Korochanskaya T. L. Lapina I. V. Maev R. V. Maslennikov R. G. Myazin P. V. Pavlov M. V. Perekalina N. A. Pisarenko A. V. Povtoreyko E. A. Poluektova L. A. Sekretareva A. V. Tkachev Yu. M. Troshkina A. S. Trukhmanov A. I. Ulyanin S. G. Filatova V. V. Tsukanov O. S. Shifrin |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | Аim: the clinical practice guidelines intended for gastroenterologists, internal medicine specialists, infectious disease specialists, general practitioners (family doctors), coloproctologists, surgeons and endoscopists present modern methods of diagnosis, prevention and treatment of C. difficile-associated disease.Key points. C. difficile-associated disease is a disease that develops when the diversity of the intestinal microbiota decreases and C. difficile excessively colonizes the colon, the toxins of which damage the intestinal muco-epithelial barrier, followed by the development of inflammation in the colon wall, with diarrhea being a characteristic clinical manifestation. The clinical presentation of the disease can vary from asymptomatic carriage, mild to moderate diarrhea that resolves on its own, to profuse watery diarrhea and pseudomembranous colitis with development of life-threatening complications. The diagnosis of C. difficile-associated disease is based on an assessment of the clinical presentation, medical history, an objective examination of the patient and laboratory stool tests. The disease severity is determined by clinical symptoms and laboratory findings. Additional diagnostic methods that are used according to indications and contribute to the assessment of severity include endoscopy of the colon and abdominal cavity imaging methods. Treatment should be initiated in cases of characteristic clinical presentation of C. difficile-associated disease and positive laboratory stool testing. The choice of drug and treatment regimen depends on the severity of the episode, the presence of complications, and whether the episode is initial, recurrent, or reinfection.Conclusion. Determination of target groups of patients for the diagnosis of clostridial infection is important in preventing overdiagnosis and subsequent unnecessary treatment. Timely diagnosis and treatment of C. difficile-associated disease help avoiding the development of life-threatening complications and improve the prognosis and quality of life of patients. |
| format | Article |
| id | doaj-art-8cbbe2c5b06d4ea099c4db9cffcb50ee |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2023-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-8cbbe2c5b06d4ea099c4db9cffcb50ee2025-02-10T16:14:38ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732023-09-013338511910.22416/1382-4376-2023-33-3-85-119549Clinical Practice Guidelines of the Scientific Society for the Clinical Study of Human Microbiome, of the Russian Gastroenterological Association and the Russian Society for the Prevention of Noncommunicable Diseases on the Diagnosis and Treatment of <i>Clostridioides difficile</i> (<i>C. difficile</i>)-associated Disease in AdultsV. T. Ivashkin0O. S. Lyashenko1O. M. Drapkina2O. P. Alexeeva3S. A. Alekseenko4D. N. Andreev5A. Yu. Baranovsky6O. V. Goloshchapov7N. V. Zheleznova8O. Yu. Zolnikova9I. L. Kliaritskaia10N. V. Korochanskaya11T. L. Lapina12I. V. Maev13R. V. Maslennikov14R. G. Myazin15P. V. Pavlov16M. V. Perekalina17N. A. Pisarenko18A. V. Povtoreyko19E. A. Poluektova20L. A. Sekretareva21A. V. Tkachev22Yu. M. Troshkina23A. S. Trukhmanov24A. I. Ulyanin25S. G. Filatova26V. V. Tsukanov27O. S. Shifrin28I.M. Sechenov First Moscow State University (Sechenov University)I.M. Sechenov First Moscow State University (Sechenov University)National Medical Research Center for Therapy and Preventive MedicinePrivolzhsky Research Medical UniversityFar-Eastern State Medical UniversityA.I. Yevdokimov Moscow State University of Medicine and DentistrySt. Petersburg UniversityPavlov UniversityKursk Regional Multidisciplinary Clinical HospitalI.M. Sechenov First Moscow State University (Sechenov University)V.I. Vernadsky Crimean Federal UniversityKuban State Medical UniversityI.M. Sechenov First Moscow State University (Sechenov University)A.I. Yevdokimov Moscow State University of Medicine and DentistryI.M. Sechenov First Moscow State University (Sechenov University)Volgograd State Medical UniversityI.M. Sechenov First Moscow State University (Sechenov University)Stavropol Regional Clinical HospitalA.S. Lukashevsky Kamchatka Regional HospitalPskov Regional Infectious Diseases HospitalI.M. Sechenov First Moscow State University (Sechenov University)Medical Sanitary Unit No. 1Rostov State Medical UniversityTula Regional Clinical HospitalI.M. Sechenov First Moscow State University (Sechenov University)I.M. Sechenov First Moscow State University (Sechenov University)V.D. Babenko Tambov Regional Clinical HospitalFederal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”I.M. Sechenov First Moscow State University (Sechenov University)Аim: the clinical practice guidelines intended for gastroenterologists, internal medicine specialists, infectious disease specialists, general practitioners (family doctors), coloproctologists, surgeons and endoscopists present modern methods of diagnosis, prevention and treatment of C. difficile-associated disease.Key points. C. difficile-associated disease is a disease that develops when the diversity of the intestinal microbiota decreases and C. difficile excessively colonizes the colon, the toxins of which damage the intestinal muco-epithelial barrier, followed by the development of inflammation in the colon wall, with diarrhea being a characteristic clinical manifestation. The clinical presentation of the disease can vary from asymptomatic carriage, mild to moderate diarrhea that resolves on its own, to profuse watery diarrhea and pseudomembranous colitis with development of life-threatening complications. The diagnosis of C. difficile-associated disease is based on an assessment of the clinical presentation, medical history, an objective examination of the patient and laboratory stool tests. The disease severity is determined by clinical symptoms and laboratory findings. Additional diagnostic methods that are used according to indications and contribute to the assessment of severity include endoscopy of the colon and abdominal cavity imaging methods. Treatment should be initiated in cases of characteristic clinical presentation of C. difficile-associated disease and positive laboratory stool testing. The choice of drug and treatment regimen depends on the severity of the episode, the presence of complications, and whether the episode is initial, recurrent, or reinfection.Conclusion. Determination of target groups of patients for the diagnosis of clostridial infection is important in preventing overdiagnosis and subsequent unnecessary treatment. Timely diagnosis and treatment of C. difficile-associated disease help avoiding the development of life-threatening complications and improve the prognosis and quality of life of patients.https://www.gastro-j.ru/jour/article/view/820<i>c. difficile</i>-associated diseasepseudomembranous colitisintestinal microbiotaantibiotic therapyfecal microbiota transplant |
| spellingShingle | V. T. Ivashkin O. S. Lyashenko O. M. Drapkina O. P. Alexeeva S. A. Alekseenko D. N. Andreev A. Yu. Baranovsky O. V. Goloshchapov N. V. Zheleznova O. Yu. Zolnikova I. L. Kliaritskaia N. V. Korochanskaya T. L. Lapina I. V. Maev R. V. Maslennikov R. G. Myazin P. V. Pavlov M. V. Perekalina N. A. Pisarenko A. V. Povtoreyko E. A. Poluektova L. A. Sekretareva A. V. Tkachev Yu. M. Troshkina A. S. Trukhmanov A. I. Ulyanin S. G. Filatova V. V. Tsukanov O. S. Shifrin Clinical Practice Guidelines of the Scientific Society for the Clinical Study of Human Microbiome, of the Russian Gastroenterological Association and the Russian Society for the Prevention of Noncommunicable Diseases on the Diagnosis and Treatment of <i>Clostridioides difficile</i> (<i>C. difficile</i>)-associated Disease in Adults Российский журнал гастроэнтерологии, гепатологии, колопроктологии <i>c. difficile</i>-associated disease pseudomembranous colitis intestinal microbiota antibiotic therapy fecal microbiota transplant |
| title | Clinical Practice Guidelines of the Scientific Society for the Clinical Study of Human Microbiome, of the Russian Gastroenterological Association and the Russian Society for the Prevention of Noncommunicable Diseases on the Diagnosis and Treatment of <i>Clostridioides difficile</i> (<i>C. difficile</i>)-associated Disease in Adults |
| title_full | Clinical Practice Guidelines of the Scientific Society for the Clinical Study of Human Microbiome, of the Russian Gastroenterological Association and the Russian Society for the Prevention of Noncommunicable Diseases on the Diagnosis and Treatment of <i>Clostridioides difficile</i> (<i>C. difficile</i>)-associated Disease in Adults |
| title_fullStr | Clinical Practice Guidelines of the Scientific Society for the Clinical Study of Human Microbiome, of the Russian Gastroenterological Association and the Russian Society for the Prevention of Noncommunicable Diseases on the Diagnosis and Treatment of <i>Clostridioides difficile</i> (<i>C. difficile</i>)-associated Disease in Adults |
| title_full_unstemmed | Clinical Practice Guidelines of the Scientific Society for the Clinical Study of Human Microbiome, of the Russian Gastroenterological Association and the Russian Society for the Prevention of Noncommunicable Diseases on the Diagnosis and Treatment of <i>Clostridioides difficile</i> (<i>C. difficile</i>)-associated Disease in Adults |
| title_short | Clinical Practice Guidelines of the Scientific Society for the Clinical Study of Human Microbiome, of the Russian Gastroenterological Association and the Russian Society for the Prevention of Noncommunicable Diseases on the Diagnosis and Treatment of <i>Clostridioides difficile</i> (<i>C. difficile</i>)-associated Disease in Adults |
| title_sort | clinical practice guidelines of the scientific society for the clinical study of human microbiome of the russian gastroenterological association and the russian society for the prevention of noncommunicable diseases on the diagnosis and treatment of i clostridioides difficile i i c difficile i associated disease in adults |
| topic | <i>c. difficile</i>-associated disease pseudomembranous colitis intestinal microbiota antibiotic therapy fecal microbiota transplant |
| url | https://www.gastro-j.ru/jour/article/view/820 |
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