Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular docking
Aartocarpus chaplasha is a medicinal tree native to tropical regions, valued for its diverse therapeutic properties and bioactive compounds found in its leaves, bark, and fruit. This study investigates the analgesic and anthelmintic properties of the ethanolic leaf extract of Aartocarpus chaplasha (...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
|
| Series: | Phytomedicine Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266703132500034X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823859409722277888 |
|---|---|
| author | S M Sohag Sharmin Nur Toma Md. Niaj Morshed Md. Al Imran Imon Md. Monirul Islam Md. Ibnul Piash Naznin Shahria Imran Mahmud |
| author_facet | S M Sohag Sharmin Nur Toma Md. Niaj Morshed Md. Al Imran Imon Md. Monirul Islam Md. Ibnul Piash Naznin Shahria Imran Mahmud |
| author_sort | S M Sohag |
| collection | DOAJ |
| description | Aartocarpus chaplasha is a medicinal tree native to tropical regions, valued for its diverse therapeutic properties and bioactive compounds found in its leaves, bark, and fruit. This study investigates the analgesic and anthelmintic properties of the ethanolic leaf extract of Aartocarpus chaplasha (ELAC). HPLC analysis identified key compounds in ELAC, including catechin hydrate, epicatechin, rutin hydrate, p-coumaric acid, rosmarinic acid, quercetin, and kaemferol. ADMET properties and molecular docking analysis were performed using the identified compounds and analgesic targets COX-1 and COX-2 and the anthelmintic target tubulin-colchicine. Analgesic activity was assessed using the acetic acid-induced writhing test on Swiss albino mice, while anthelmintic effects were evaluated against Paramphistomum cervi. In silico molecular docking suggested that catechin hydrate and kaempferol could be promising alternatives for analgesic activity due to their higher binding energy with COX-1 and COX-2. Moreover, rutin hydrate showed strong binding energy with tubulin-colchicine against anthelmintic properties. At a 500 mg/kg dosage, ELAC exhibited significant analgesic effects. In the anthelmintic tests, a 100 mg/mL concentration resulted in the lowest paralysis and death times of 14.03 and 18.03 mins, respectively. Our present study suggests that Aartocarpus chaplasha leaves can be a potential source of lead compounds for pain management and helminth infections and further advanced investigations are required in the future. |
| format | Article |
| id | doaj-art-8d53e28c28e64fc3bee092f3fcbd6e5f |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-8d53e28c28e64fc3bee092f3fcbd6e5f2025-02-11T04:35:33ZengElsevierPhytomedicine Plus2667-03132025-05-0152100761Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular dockingS M Sohag0Sharmin Nur Toma1Md. Niaj Morshed2Md. Al Imran Imon3Md. Monirul Islam4Md. Ibnul Piash5Naznin Shahria6Imran Mahmud7Department of Pharmacy, Khwaja Yunus Ali University, Enayetpur, Chouhali, Sirajganj 6751, BangladeshDepartment of Pharmacy, Islamic University, Kushtia, BangladeshDepartment of Biopharmaceutical Biotechnology, College of Life Sciences, Kyung Hee University, Global Campus, South KoreaDepartment of Pharmacy, Khwaja Yunus Ali University, Enayetpur, Chouhali, Sirajganj 6751, BangladeshDepartment of Pharmacy, Khwaja Yunus Ali University, Enayetpur, Chouhali, Sirajganj 6751, BangladeshDepartment of Pharmacy, Khwaja Yunus Ali University, Enayetpur, Chouhali, Sirajganj 6751, BangladeshDepartment of Pharmacy, Khwaja Yunus Ali University, Enayetpur, Chouhali, Sirajganj 6751, BangladeshDepartment of Pharmacy, Khwaja Yunus Ali University, Enayetpur, Chouhali, Sirajganj 6751, Bangladesh; Corresponding author at: Department of Pharmacy, Khwaja Yunus Ali University, Enayetpur, Sirajganj.Aartocarpus chaplasha is a medicinal tree native to tropical regions, valued for its diverse therapeutic properties and bioactive compounds found in its leaves, bark, and fruit. This study investigates the analgesic and anthelmintic properties of the ethanolic leaf extract of Aartocarpus chaplasha (ELAC). HPLC analysis identified key compounds in ELAC, including catechin hydrate, epicatechin, rutin hydrate, p-coumaric acid, rosmarinic acid, quercetin, and kaemferol. ADMET properties and molecular docking analysis were performed using the identified compounds and analgesic targets COX-1 and COX-2 and the anthelmintic target tubulin-colchicine. Analgesic activity was assessed using the acetic acid-induced writhing test on Swiss albino mice, while anthelmintic effects were evaluated against Paramphistomum cervi. In silico molecular docking suggested that catechin hydrate and kaempferol could be promising alternatives for analgesic activity due to their higher binding energy with COX-1 and COX-2. Moreover, rutin hydrate showed strong binding energy with tubulin-colchicine against anthelmintic properties. At a 500 mg/kg dosage, ELAC exhibited significant analgesic effects. In the anthelmintic tests, a 100 mg/mL concentration resulted in the lowest paralysis and death times of 14.03 and 18.03 mins, respectively. Our present study suggests that Aartocarpus chaplasha leaves can be a potential source of lead compounds for pain management and helminth infections and further advanced investigations are required in the future.http://www.sciencedirect.com/science/article/pii/S266703132500034XAartocarpus chaplashaAnalgesicAnthelminticHPLCIn silicoADMET |
| spellingShingle | S M Sohag Sharmin Nur Toma Md. Niaj Morshed Md. Al Imran Imon Md. Monirul Islam Md. Ibnul Piash Naznin Shahria Imran Mahmud Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular docking Phytomedicine Plus Aartocarpus chaplasha Analgesic Anthelmintic HPLC In silico ADMET |
| title | Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular docking |
| title_full | Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular docking |
| title_fullStr | Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular docking |
| title_full_unstemmed | Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular docking |
| title_short | Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular docking |
| title_sort | exploration of analgesic and anthelmintic activities of artocarpus chaplasha roxb leaves supported by in silico molecular docking |
| topic | Aartocarpus chaplasha Analgesic Anthelmintic HPLC In silico ADMET |
| url | http://www.sciencedirect.com/science/article/pii/S266703132500034X |
| work_keys_str_mv | AT smsohag explorationofanalgesicandanthelminticactivitiesofartocarpuschaplasharoxbleavessupportedbyinsilicomoleculardocking AT sharminnurtoma explorationofanalgesicandanthelminticactivitiesofartocarpuschaplasharoxbleavessupportedbyinsilicomoleculardocking AT mdniajmorshed explorationofanalgesicandanthelminticactivitiesofartocarpuschaplasharoxbleavessupportedbyinsilicomoleculardocking AT mdalimranimon explorationofanalgesicandanthelminticactivitiesofartocarpuschaplasharoxbleavessupportedbyinsilicomoleculardocking AT mdmonirulislam explorationofanalgesicandanthelminticactivitiesofartocarpuschaplasharoxbleavessupportedbyinsilicomoleculardocking AT mdibnulpiash explorationofanalgesicandanthelminticactivitiesofartocarpuschaplasharoxbleavessupportedbyinsilicomoleculardocking AT nazninshahria explorationofanalgesicandanthelminticactivitiesofartocarpuschaplasharoxbleavessupportedbyinsilicomoleculardocking AT imranmahmud explorationofanalgesicandanthelminticactivitiesofartocarpuschaplasharoxbleavessupportedbyinsilicomoleculardocking |