Triglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patients
Abstract Heart failure (HF), a major cause of morbidity and mortality worldwide, is prevalent among individuals with H-type hypertension, which is marked by high blood pressure and elevated homocysteine. The Triglyceride-Glucose (TyG) index, a surrogate for insulin resistance, may predict HF in this...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-89211-w |
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| author | Zhengwen Xu Xisheng Yan Dongsheng Li Xiaodong Huang |
| author_facet | Zhengwen Xu Xisheng Yan Dongsheng Li Xiaodong Huang |
| author_sort | Zhengwen Xu |
| collection | DOAJ |
| description | Abstract Heart failure (HF), a major cause of morbidity and mortality worldwide, is prevalent among individuals with H-type hypertension, which is marked by high blood pressure and elevated homocysteine. The Triglyceride-Glucose (TyG) index, a surrogate for insulin resistance, may predict HF in this group, though its specific role requires clarification. This study explores the TyG index’s relationship with HF incidence in H-type hypertension patients. A retrospective cohort study was conducted on 1200 H-type hypertension patients at Wuhan Third Hospital from January 2021 to December 2023. The TyG index was determined using fasting triglyceride and glucose levels. We utilized multivariate Cox regression, adjusting for age, sex, BMI, and lifestyle, to analyze the TyG index’s impact on HF. Of the 1,200 patients studied, 254 (21.2%) developed HF over a median follow-up of 24 months. Higher TyG index values significantly correlated with increased HF risk, with each unit rise boosting HF incidence by 45%. Patients in the highest TyG tertile had a notably higher HF incidence (HR 1.45, 95% CI 1.29–1.63, p < 0.001). This association was stronger in diabetic patients compared to non-diabetics. The TyG index showed high predictive accuracy (AUC = 0.78) with good sensitivity (70.9%) and specificity (72.3%) at a cut-off of 8.88. Elevated TyG index significantly predicts higher HF risk in H-type hypertension patients, especially among diabetics. Integrating the TyG index into routine evaluations could improve management and outcomes for high-risk individuals, offering an economical early risk stratification tool. |
| format | Article |
| id | doaj-art-8d6d65cd16bd48d1b8e21d41493ce8c8 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-8d6d65cd16bd48d1b8e21d41493ce8c82025-02-09T12:32:01ZengNature PortfolioScientific Reports2045-23222025-02-0115111010.1038/s41598-025-89211-wTriglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patientsZhengwen Xu0Xisheng Yan1Dongsheng Li2Xiaodong Huang3Department of Cardiology, Wuhan Third Hospital & Tongren Hospital of Wuhan UniversityDepartment of Cardiology, Wuhan Third Hospital & Tongren Hospital of Wuhan UniversityDepartment of Cardiology, Wuhan Third Hospital & Tongren Hospital of Wuhan UniversityDepartment of Cardiology, Wuhan Third Hospital & Tongren Hospital of Wuhan UniversityAbstract Heart failure (HF), a major cause of morbidity and mortality worldwide, is prevalent among individuals with H-type hypertension, which is marked by high blood pressure and elevated homocysteine. The Triglyceride-Glucose (TyG) index, a surrogate for insulin resistance, may predict HF in this group, though its specific role requires clarification. This study explores the TyG index’s relationship with HF incidence in H-type hypertension patients. A retrospective cohort study was conducted on 1200 H-type hypertension patients at Wuhan Third Hospital from January 2021 to December 2023. The TyG index was determined using fasting triglyceride and glucose levels. We utilized multivariate Cox regression, adjusting for age, sex, BMI, and lifestyle, to analyze the TyG index’s impact on HF. Of the 1,200 patients studied, 254 (21.2%) developed HF over a median follow-up of 24 months. Higher TyG index values significantly correlated with increased HF risk, with each unit rise boosting HF incidence by 45%. Patients in the highest TyG tertile had a notably higher HF incidence (HR 1.45, 95% CI 1.29–1.63, p < 0.001). This association was stronger in diabetic patients compared to non-diabetics. The TyG index showed high predictive accuracy (AUC = 0.78) with good sensitivity (70.9%) and specificity (72.3%) at a cut-off of 8.88. Elevated TyG index significantly predicts higher HF risk in H-type hypertension patients, especially among diabetics. Integrating the TyG index into routine evaluations could improve management and outcomes for high-risk individuals, offering an economical early risk stratification tool.https://doi.org/10.1038/s41598-025-89211-wHeart failureDiabetesTriglyceride glucose indexH-type hypertension |
| spellingShingle | Zhengwen Xu Xisheng Yan Dongsheng Li Xiaodong Huang Triglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patients Scientific Reports Heart failure Diabetes Triglyceride glucose index H-type hypertension |
| title | Triglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patients |
| title_full | Triglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patients |
| title_fullStr | Triglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patients |
| title_full_unstemmed | Triglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patients |
| title_short | Triglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patients |
| title_sort | triglyceride glucose index as a biomarker for heart failure risk in h type hypertension patients |
| topic | Heart failure Diabetes Triglyceride glucose index H-type hypertension |
| url | https://doi.org/10.1038/s41598-025-89211-w |
| work_keys_str_mv | AT zhengwenxu triglycerideglucoseindexasabiomarkerforheartfailureriskinhtypehypertensionpatients AT xishengyan triglycerideglucoseindexasabiomarkerforheartfailureriskinhtypehypertensionpatients AT dongshengli triglycerideglucoseindexasabiomarkerforheartfailureriskinhtypehypertensionpatients AT xiaodonghuang triglycerideglucoseindexasabiomarkerforheartfailureriskinhtypehypertensionpatients |