Recent advances of nanovaccines on cancer theranostics
Cancer is a leading cause of death worldwide, with an estimated 20 million new cancer cases and 9.7 million cancer deaths worldwide in 2022. Immunotherapy provides innovative strategies among the most groundbreaking developments in cancer treatment. Cancer vaccines, as a form of immunotherapy, have...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Nanotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnano.2025.1521131/full |
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| author | Xiaobing Yuan Xiaobing Yuan Xiaobing Yuan Tianyou Xu Mubashir Hussain Bin Liu Jianwei Zhu Jianwei Zhu |
| author_facet | Xiaobing Yuan Xiaobing Yuan Xiaobing Yuan Tianyou Xu Mubashir Hussain Bin Liu Jianwei Zhu Jianwei Zhu |
| author_sort | Xiaobing Yuan |
| collection | DOAJ |
| description | Cancer is a leading cause of death worldwide, with an estimated 20 million new cancer cases and 9.7 million cancer deaths worldwide in 2022. Immunotherapy provides innovative strategies among the most groundbreaking developments in cancer treatment. Cancer vaccines, as a form of immunotherapy, have a great prospect to help patients resistant to other standard-of-care immunotherapies. On the other hand, the various properties of nanomaterials play an essential role in the collecting, maturation, and activation of the immune system. Cancer vaccines based on nanomaterials (also called nanovaccines) can be specifically delivered to target tissues and cells through nanocarriers and nanoplatforms, thereby improving efficacy, extending the duration of antitumor immunity, and minimizing side effects. This paper reviewed the research progress of some nanovaccines in cancer immunotherapy, including polymer nanoparticle vaccine, liposome nanoparticle vaccine, cell-based nanoparticle vaccine, inorganic nanoparticle vaccine, adjuvant and auxiliary work. We believe that polymer nanoparticle-based nanovaccines have the most widespread applications currently, while liposome nanovaccines using mRNA are expected to see greater development in the future. We also think that nanovaccines can play a great role in cancer prevention and treatment, especially in prolonging the life span of patients. |
| format | Article |
| id | doaj-art-8dcd80432abd4665b2da1ce5a7487ac6 |
| institution | Kabale University |
| issn | 2673-3013 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nanotechnology |
| spelling | doaj-art-8dcd80432abd4665b2da1ce5a7487ac62025-02-12T07:26:38ZengFrontiers Media S.A.Frontiers in Nanotechnology2673-30132025-02-01710.3389/fnano.2025.15211311521131Recent advances of nanovaccines on cancer theranosticsXiaobing Yuan0Xiaobing Yuan1Xiaobing Yuan2Tianyou Xu3Mubashir Hussain4Bin Liu5Jianwei Zhu6Jianwei Zhu7School of Medicine, Nantong University, Nantong, ChinaDepartment of Gastrointestinal Surgery, People’s Hospital of Rugao, Nantong, ChinaDepartment of General Surgery, Affiliated Hospital of Nantong University, Nantong, ChinaEngineering Research Center of Intelligent Theranostics Technology and Instruments, Ministry of Education, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, ChinaChangzhou Medical Center, Changzhou Second People’s Hospital, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Nanjing Medical University, Changzhou, ChinaEngineering Research Center of Intelligent Theranostics Technology and Instruments, Ministry of Education, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, ChinaSchool of Medicine, Nantong University, Nantong, ChinaDepartment of General Surgery, Affiliated Hospital of Nantong University, Nantong, ChinaCancer is a leading cause of death worldwide, with an estimated 20 million new cancer cases and 9.7 million cancer deaths worldwide in 2022. Immunotherapy provides innovative strategies among the most groundbreaking developments in cancer treatment. Cancer vaccines, as a form of immunotherapy, have a great prospect to help patients resistant to other standard-of-care immunotherapies. On the other hand, the various properties of nanomaterials play an essential role in the collecting, maturation, and activation of the immune system. Cancer vaccines based on nanomaterials (also called nanovaccines) can be specifically delivered to target tissues and cells through nanocarriers and nanoplatforms, thereby improving efficacy, extending the duration of antitumor immunity, and minimizing side effects. This paper reviewed the research progress of some nanovaccines in cancer immunotherapy, including polymer nanoparticle vaccine, liposome nanoparticle vaccine, cell-based nanoparticle vaccine, inorganic nanoparticle vaccine, adjuvant and auxiliary work. We believe that polymer nanoparticle-based nanovaccines have the most widespread applications currently, while liposome nanovaccines using mRNA are expected to see greater development in the future. We also think that nanovaccines can play a great role in cancer prevention and treatment, especially in prolonging the life span of patients.https://www.frontiersin.org/articles/10.3389/fnano.2025.1521131/fullnanoparticlesnanovaccinesimmunotherapycancertheranostics |
| spellingShingle | Xiaobing Yuan Xiaobing Yuan Xiaobing Yuan Tianyou Xu Mubashir Hussain Bin Liu Jianwei Zhu Jianwei Zhu Recent advances of nanovaccines on cancer theranostics Frontiers in Nanotechnology nanoparticles nanovaccines immunotherapy cancer theranostics |
| title | Recent advances of nanovaccines on cancer theranostics |
| title_full | Recent advances of nanovaccines on cancer theranostics |
| title_fullStr | Recent advances of nanovaccines on cancer theranostics |
| title_full_unstemmed | Recent advances of nanovaccines on cancer theranostics |
| title_short | Recent advances of nanovaccines on cancer theranostics |
| title_sort | recent advances of nanovaccines on cancer theranostics |
| topic | nanoparticles nanovaccines immunotherapy cancer theranostics |
| url | https://www.frontiersin.org/articles/10.3389/fnano.2025.1521131/full |
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