Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatment
The aim of review. To generalize new data on diagnostics, pathogenesis and treatment of autoimmune hepatitis (AIH).Original positions. AIH is a chronic inflammatory liver disease which is characterized by destruction of terminal plate by mononuclear infiltrate (interface hepatitis) according to hist...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2012-09-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1321 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860213040545792 |
|---|---|
| author | Ye. N. Shirokova K. V. Ivashkin V. T. Ivashkin |
| author_facet | Ye. N. Shirokova K. V. Ivashkin V. T. Ivashkin |
| author_sort | Ye. N. Shirokova |
| collection | DOAJ |
| description | The aim of review. To generalize new data on diagnostics, pathogenesis and treatment of autoimmune hepatitis (AIH).Original positions. AIH is a chronic inflammatory liver disease which is characterized by destruction of terminal plate by mononuclear infiltrate (interface hepatitis) according to histological investigation, hypergammaglobulinemia and production of autoantibodies. Genetic risk factors of AIH development is the presence of DRB1*0301 and DRB1*0401 alleles. Decrease of number and functional activity of CD4+CD25 + (regulatory) Т-cells leads to disorder of immunological homeostasis. Improvement of AIH treatment results is possible at continuation of corticosteroid treatment before normalization of liver tests and histological pattern, at early detection of «difficult» patients and carrying out of long-term maintenance therapy after the first relapse of disease. Alternative medical agents include calcineurin inhibitors, mycophenolate mofetil, and recombinant interleukin-10, abatacept and CD-3 specific antibodies. Liver transplantation is effictive treatment method.Conclusion. Improvement of corticosteroid treatment allows to determine candidates for alternative treatment. Budesonide is a drug of choice for the patients who were not receiving treatment before. Development of new treatment strategy is possible on the basis of assessment of key defects of immunological homeostasis and antigenic targets. |
| format | Article |
| id | doaj-art-8deca696358b431c8f8bd817a84d3267 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2012-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-8deca696358b431c8f8bd817a84d32672025-02-10T16:14:32ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732012-09-012253745893Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatmentYe. N. Shirokova0K. V. Ivashkin1V. T. Ivashkin2ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздравсоцразвития РФГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздравсоцразвития РФГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздравсоцразвития РФThe aim of review. To generalize new data on diagnostics, pathogenesis and treatment of autoimmune hepatitis (AIH).Original positions. AIH is a chronic inflammatory liver disease which is characterized by destruction of terminal plate by mononuclear infiltrate (interface hepatitis) according to histological investigation, hypergammaglobulinemia and production of autoantibodies. Genetic risk factors of AIH development is the presence of DRB1*0301 and DRB1*0401 alleles. Decrease of number and functional activity of CD4+CD25 + (regulatory) Т-cells leads to disorder of immunological homeostasis. Improvement of AIH treatment results is possible at continuation of corticosteroid treatment before normalization of liver tests and histological pattern, at early detection of «difficult» patients and carrying out of long-term maintenance therapy after the first relapse of disease. Alternative medical agents include calcineurin inhibitors, mycophenolate mofetil, and recombinant interleukin-10, abatacept and CD-3 specific antibodies. Liver transplantation is effictive treatment method.Conclusion. Improvement of corticosteroid treatment allows to determine candidates for alternative treatment. Budesonide is a drug of choice for the patients who were not receiving treatment before. Development of new treatment strategy is possible on the basis of assessment of key defects of immunological homeostasis and antigenic targets.https://www.gastro-j.ru/jour/article/view/1321autoimmune hepatitisimmunosuppressionprednisolonazathioprinbudesonide |
| spellingShingle | Ye. N. Shirokova K. V. Ivashkin V. T. Ivashkin Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatment Российский журнал гастроэнтерологии, гепатологии, колопроктологии autoimmune hepatitis immunosuppression prednisolon azathioprin budesonide |
| title | Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatment |
| title_full | Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatment |
| title_fullStr | Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatment |
| title_full_unstemmed | Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatment |
| title_short | Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatment |
| title_sort | autoimmune hepatitis new in diagnostics a pathogenesis and treatment |
| topic | autoimmune hepatitis immunosuppression prednisolon azathioprin budesonide |
| url | https://www.gastro-j.ru/jour/article/view/1321 |
| work_keys_str_mv | AT yenshirokova autoimmunehepatitisnewindiagnosticsapathogenesisandtreatment AT kvivashkin autoimmunehepatitisnewindiagnosticsapathogenesisandtreatment AT vtivashkin autoimmunehepatitisnewindiagnosticsapathogenesisandtreatment |