Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study
Abstract Background Vital signs help determine the safety of early mobilization in critically ill patients in intensive care units. However, none of these variables directly assess cerebral circulation. Therefore, we aimed to investigate the relationship of regional cerebral oxygen saturation (rSO2)...
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SpringerOpen
2025-02-01
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| Series: | Intensive Care Medicine Experimental |
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| Online Access: | https://doi.org/10.1186/s40635-025-00722-2 |
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| author | Ryota Imai Takafumi Abe Kentaro Iwata Seigo Yamaguchi Takeshi Kitai Atsuhiro Tsubaki |
| author_facet | Ryota Imai Takafumi Abe Kentaro Iwata Seigo Yamaguchi Takeshi Kitai Atsuhiro Tsubaki |
| author_sort | Ryota Imai |
| collection | DOAJ |
| description | Abstract Background Vital signs help determine the safety of early mobilization in critically ill patients in intensive care units. However, none of these variables directly assess cerebral circulation. Therefore, we aimed to investigate the relationship of regional cerebral oxygen saturation (rSO2) and vital signs with in-hospital death in critically ill patients. Methods This prospective study included critically ill patients admitted to the Uonuma Kikan Hospital Emergency Center who received physical therapy between June 2020 and December 2022. We continuously measured rSO2 during the initial mobilization using a wearable brain near-infrared spectroscopy device. With in-hospital death as the primary endpoint, the association between rSO2 and in-hospital death was assessed in Analysis 1 to determine the rSO2 cut-off value that predicts in-hospital death. In Analysis 2, patients were categorised into survival and non-survival groups to examine the temporal changes in vital signs and rSO2 associated with postural changes during mobilization. Results Of the 132 eligible patients, 98 were included in Analysis 1, and 70 were included in Analysis 2. Analysis 1 demonstrated that lower premobilization rSO2 was independently associated with in-hospital death (odds ratio 0.835, 95% confidence interval 0.724–0.961, p = 0.012). Receiver operating characteristic curve analysis identified an optimal rSO2 cut-off value of 57% for predicting in-hospital death (area under the curve 0.818, sensitivity 73%, specificity 83%). Analysis 2 showed that rSO2 changes during mobilization were unrelated to changes in vital signs, suggesting rSO2 as an independent prognostic marker. Conclusions The results suggest that rSO2 measured during initial mobilization is associated with in-hospital death in critically ill patients. |
| format | Article |
| id | doaj-art-8e7abe22313947cf9d3f4baf6588bf72 |
| institution | Kabale University |
| issn | 2197-425X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Intensive Care Medicine Experimental |
| spelling | doaj-art-8e7abe22313947cf9d3f4baf6588bf722025-02-09T12:04:36ZengSpringerOpenIntensive Care Medicine Experimental2197-425X2025-02-0113111410.1186/s40635-025-00722-2Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational studyRyota Imai0Takafumi Abe1Kentaro Iwata2Seigo Yamaguchi3Takeshi Kitai4Atsuhiro Tsubaki5Department of Rehabilitation, Uonuma Kikan HospitalDepartment of Rehabilitation, Uonuma Kikan HospitalDepartment of Rehabilitation, Kobe City Medical Center General HospitalDepartment of Emergency and Critical Care, Uonuma Kikan HospitalDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular CenterInstitute for Human Movement and Medical Sciences, Niigata University of Health and WelfareAbstract Background Vital signs help determine the safety of early mobilization in critically ill patients in intensive care units. However, none of these variables directly assess cerebral circulation. Therefore, we aimed to investigate the relationship of regional cerebral oxygen saturation (rSO2) and vital signs with in-hospital death in critically ill patients. Methods This prospective study included critically ill patients admitted to the Uonuma Kikan Hospital Emergency Center who received physical therapy between June 2020 and December 2022. We continuously measured rSO2 during the initial mobilization using a wearable brain near-infrared spectroscopy device. With in-hospital death as the primary endpoint, the association between rSO2 and in-hospital death was assessed in Analysis 1 to determine the rSO2 cut-off value that predicts in-hospital death. In Analysis 2, patients were categorised into survival and non-survival groups to examine the temporal changes in vital signs and rSO2 associated with postural changes during mobilization. Results Of the 132 eligible patients, 98 were included in Analysis 1, and 70 were included in Analysis 2. Analysis 1 demonstrated that lower premobilization rSO2 was independently associated with in-hospital death (odds ratio 0.835, 95% confidence interval 0.724–0.961, p = 0.012). Receiver operating characteristic curve analysis identified an optimal rSO2 cut-off value of 57% for predicting in-hospital death (area under the curve 0.818, sensitivity 73%, specificity 83%). Analysis 2 showed that rSO2 changes during mobilization were unrelated to changes in vital signs, suggesting rSO2 as an independent prognostic marker. Conclusions The results suggest that rSO2 measured during initial mobilization is associated with in-hospital death in critically ill patients.https://doi.org/10.1186/s40635-025-00722-2Critically ill patientsEarly mobilizationNear-infrared spectroscopyRegional cerebral oxygen saturationRehabilitation |
| spellingShingle | Ryota Imai Takafumi Abe Kentaro Iwata Seigo Yamaguchi Takeshi Kitai Atsuhiro Tsubaki Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study Intensive Care Medicine Experimental Critically ill patients Early mobilization Near-infrared spectroscopy Regional cerebral oxygen saturation Rehabilitation |
| title | Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study |
| title_full | Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study |
| title_fullStr | Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study |
| title_full_unstemmed | Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study |
| title_short | Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study |
| title_sort | regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes a prospective observational study |
| topic | Critically ill patients Early mobilization Near-infrared spectroscopy Regional cerebral oxygen saturation Rehabilitation |
| url | https://doi.org/10.1186/s40635-025-00722-2 |
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