Alternative RNA Splicing in Cardiac Diseases
Alternative splicing (AS), a critical process for gene expression regulation, allows a single precursor RNA to produce multiple transcript variants. Alterations in exon exclusion, intron retention, or the selection of alternative splice sites modify transcript isoforms, which can consequently affect...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2025-01-01
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| Series: | Cardiovascular Innovations and Applications |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0060 |
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| _version_ | 1825201925431230464 |
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| author | Junli Gao Yanan Zhang Meiyu Hu Tao He Xiaohang Yin Tian Hao Guoping Li Junjie Xiao |
| author_facet | Junli Gao Yanan Zhang Meiyu Hu Tao He Xiaohang Yin Tian Hao Guoping Li Junjie Xiao |
| author_sort | Junli Gao |
| collection | DOAJ |
| description | Alternative splicing (AS), a critical process for gene expression regulation, allows a single precursor RNA to produce multiple transcript variants. Alterations in exon exclusion, intron retention, or the selection of alternative splice sites modify transcript isoforms, which can consequently affect RNA molecules, including mRNA and non-coding RNAs, in terms of their localization, regulation, and overall function. In the cardiovascular system, AS of transcripts of sarcomere, ion channel, and cell signaling protein genes, as well as long non-coding RNAs, can contribute to the development of cardiovascular diseases. In addition, multiple hereditary heart-related diseases are caused by mutations associated with AS. In this review, we discuss how AS regulates individual genes and global biological processes, thereby diversifying the expression patterns of target genes and playing critical roles in cardiovascular diseases. We also review the application of AS in the design of innovative therapeutic approaches. |
| format | Article |
| id | doaj-art-8fa0ebb2e66d41febefbfddad962cafa |
| institution | Kabale University |
| issn | 2009-8618 2009-8782 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Cardiovascular Innovations and Applications |
| spelling | doaj-art-8fa0ebb2e66d41febefbfddad962cafa2025-02-07T17:00:10ZengCompuscript LtdCardiovascular Innovations and Applications2009-86182009-87822025-01-0110198910.15212/CVIA.2024.0060Alternative RNA Splicing in Cardiac DiseasesJunli GaoYanan ZhangMeiyu HuTao HeXiaohang YinTian HaoGuoping LiJunjie XiaoAlternative splicing (AS), a critical process for gene expression regulation, allows a single precursor RNA to produce multiple transcript variants. Alterations in exon exclusion, intron retention, or the selection of alternative splice sites modify transcript isoforms, which can consequently affect RNA molecules, including mRNA and non-coding RNAs, in terms of their localization, regulation, and overall function. In the cardiovascular system, AS of transcripts of sarcomere, ion channel, and cell signaling protein genes, as well as long non-coding RNAs, can contribute to the development of cardiovascular diseases. In addition, multiple hereditary heart-related diseases are caused by mutations associated with AS. In this review, we discuss how AS regulates individual genes and global biological processes, thereby diversifying the expression patterns of target genes and playing critical roles in cardiovascular diseases. We also review the application of AS in the design of innovative therapeutic approaches.https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0060 |
| spellingShingle | Junli Gao Yanan Zhang Meiyu Hu Tao He Xiaohang Yin Tian Hao Guoping Li Junjie Xiao Alternative RNA Splicing in Cardiac Diseases Cardiovascular Innovations and Applications |
| title | Alternative RNA Splicing in Cardiac Diseases |
| title_full | Alternative RNA Splicing in Cardiac Diseases |
| title_fullStr | Alternative RNA Splicing in Cardiac Diseases |
| title_full_unstemmed | Alternative RNA Splicing in Cardiac Diseases |
| title_short | Alternative RNA Splicing in Cardiac Diseases |
| title_sort | alternative rna splicing in cardiac diseases |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0060 |
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