Predictive factors for extubation success in very low and extremely low birth weight preterm infants
# Background Although invasive mechanical ventilation (IMV) has contributed to the survival of preterm infants with extremely low birth weight (ELBW), it is also associated with unsatisfactory clinical outcomes when used for prolonged periods. This study aimed to identify factors that may be decisi...
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| Format: | Article |
| Language: | English |
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Canadian Society of Respiratory Therapists
2023-09-01
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| Series: | Canadian Journal of Respiratory Therapy |
| Online Access: | https://doi.org/10.29390/001c.87789 |
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| author | Nilson Willamy Bastos de Souza Júnior Tathiane Ribeiro Rosa Jane Cecília Kreling Cerântola Ligia Silvana Lopes Ferrari Vanessa Suziane Probst Josiane Marques Felcar |
| author_facet | Nilson Willamy Bastos de Souza Júnior Tathiane Ribeiro Rosa Jane Cecília Kreling Cerântola Ligia Silvana Lopes Ferrari Vanessa Suziane Probst Josiane Marques Felcar |
| author_sort | Nilson Willamy Bastos de Souza Júnior |
| collection | DOAJ |
| description | # Background
Although invasive mechanical ventilation (IMV) has contributed to the survival of preterm infants with extremely low birth weight (ELBW), it is also associated with unsatisfactory clinical outcomes when used for prolonged periods. This study aimed to identify factors that may be decisive for extubation success in very low birth weight (VLBW) and extremely low birth weight (ELBW) preterm infants.
# Methods
The cohort study included preterm infants with gestational age (GA) \<36 weeks, birth weight (BW) \<1500 grams who underwent IMV, born between 2015 and 2018. The infants were allocated into two groups: extubation success (SG) or failure (FG). A stepwise logistic regression model was created to determine variables associated with successful extubation.
# Results
Eighty-three preterm infants were included. GA and post-extubation arterial partial pressure of carbon dioxide (PaCO~2~) were predictive of extubation success. Infants from FG had lower GA and BW, while those from SG had higher weight at extubation and lower post-extubation PaCO~2~.
# Discussion
Although we found post-extubation PaCO~2~ as an extubation success predictor, which is a variable representative of the moment after the primary outcome, this does not diminish its clinical relevance since extubation does not implicate in ET removal only; it also involves all the aspects that take place within a specified period (72 hours) after the planned event.
# Conclusion
GA and post-extubation PaCO~2~ were predictors for extubation success in VLBW and ELBW preterm infants. Infants who experienced extubation failure had lower birth weight and higher FiO~2~ prior to extubation. |
| format | Article |
| id | doaj-art-8fa9f05d2b7b44629a5531c380b77c73 |
| institution | Kabale University |
| issn | 2368-6820 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Canadian Society of Respiratory Therapists |
| record_format | Article |
| series | Canadian Journal of Respiratory Therapy |
| spelling | doaj-art-8fa9f05d2b7b44629a5531c380b77c732025-02-11T20:30:50ZengCanadian Society of Respiratory TherapistsCanadian Journal of Respiratory Therapy2368-68202023-09-0159Predictive factors for extubation success in very low and extremely low birth weight preterm infantsNilson Willamy Bastos de Souza JúniorTathiane Ribeiro RosaJane Cecília Kreling CerântolaLigia Silvana Lopes FerrariVanessa Suziane ProbstJosiane Marques Felcar# Background Although invasive mechanical ventilation (IMV) has contributed to the survival of preterm infants with extremely low birth weight (ELBW), it is also associated with unsatisfactory clinical outcomes when used for prolonged periods. This study aimed to identify factors that may be decisive for extubation success in very low birth weight (VLBW) and extremely low birth weight (ELBW) preterm infants. # Methods The cohort study included preterm infants with gestational age (GA) \<36 weeks, birth weight (BW) \<1500 grams who underwent IMV, born between 2015 and 2018. The infants were allocated into two groups: extubation success (SG) or failure (FG). A stepwise logistic regression model was created to determine variables associated with successful extubation. # Results Eighty-three preterm infants were included. GA and post-extubation arterial partial pressure of carbon dioxide (PaCO~2~) were predictive of extubation success. Infants from FG had lower GA and BW, while those from SG had higher weight at extubation and lower post-extubation PaCO~2~. # Discussion Although we found post-extubation PaCO~2~ as an extubation success predictor, which is a variable representative of the moment after the primary outcome, this does not diminish its clinical relevance since extubation does not implicate in ET removal only; it also involves all the aspects that take place within a specified period (72 hours) after the planned event. # Conclusion GA and post-extubation PaCO~2~ were predictors for extubation success in VLBW and ELBW preterm infants. Infants who experienced extubation failure had lower birth weight and higher FiO~2~ prior to extubation.https://doi.org/10.29390/001c.87789 |
| spellingShingle | Nilson Willamy Bastos de Souza Júnior Tathiane Ribeiro Rosa Jane Cecília Kreling Cerântola Ligia Silvana Lopes Ferrari Vanessa Suziane Probst Josiane Marques Felcar Predictive factors for extubation success in very low and extremely low birth weight preterm infants Canadian Journal of Respiratory Therapy |
| title | Predictive factors for extubation success in very low and extremely low birth weight preterm infants |
| title_full | Predictive factors for extubation success in very low and extremely low birth weight preterm infants |
| title_fullStr | Predictive factors for extubation success in very low and extremely low birth weight preterm infants |
| title_full_unstemmed | Predictive factors for extubation success in very low and extremely low birth weight preterm infants |
| title_short | Predictive factors for extubation success in very low and extremely low birth weight preterm infants |
| title_sort | predictive factors for extubation success in very low and extremely low birth weight preterm infants |
| url | https://doi.org/10.29390/001c.87789 |
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