Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation
In 2022, the Wits Transplant Unit performed 57 liver transplants: 33/57 adult (58%) and 24/57 paediatric (42%) recipients. At the beginning of 2022, 28 candidates were on the adult waitlist. Forty-six candidates were added to the waitlist during the year. Sixty-five percent of waitlisted candid...
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South African Medical Association
2024-04-01
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| Series: | South African Medical Journal |
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| Online Access: | https://samajournals.co.za/index.php/samj/article/view/1365 |
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| author | E U Wessels K Kinandu M Beretta S Berkenfeld B Bobat L Brannigan R Britz D Demopoulos L Doedens P Gaylard H Maher A Mahomed V Mudau D Parbhoo S Rambarran M Reynders F van der Schyff B Ströbele J Fabian J Loveland |
| author_facet | E U Wessels K Kinandu M Beretta S Berkenfeld B Bobat L Brannigan R Britz D Demopoulos L Doedens P Gaylard H Maher A Mahomed V Mudau D Parbhoo S Rambarran M Reynders F van der Schyff B Ströbele J Fabian J Loveland |
| author_sort | E U Wessels |
| collection | DOAJ |
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In 2022, the Wits Transplant Unit performed 57 liver transplants: 33/57 adult (58%) and 24/57 paediatric (42%) recipients. At the beginning of 2022, 28 candidates were on the adult waitlist. Forty-six candidates were added to the waitlist during the year. Sixty-five percent of waitlisted candidate were transplanted. Adult candidates remained on the waitlist for longer than previous years, with 52% of them waitlisted for less than one year before undergoing liver transplantation. There was a decrease in adult pretransplant mortality to 9% in 2021 from 25% in 2020. The most common aetiology in waitlist candidates was alcoholic steatohepatitis (ASH)/non-alcoholic steatohepatitis (NASH) (36%) and in recipients cholestatic (primary sclerosing cholangitis (PSC) and primary biliary sclerosis (PBC)) (40%). Most adult recipients received a deceased donor graft (79%). Unadjusted recipient one- and three-year survivals were 75% (95% confidence interval (CI) 65 - 83) and 74% (95% CI 65 - 81), respectively. In the paediatric population, the most common aetiologies for both pretransplant candidates and transplant recipients remained cholestatic disease and acute liver failure. There was a decrease in paediatric pretransplant mortality from 27% in 2017 to 6% in 2021. Unlike the adult cohort, most paediatric recipients received a living donor graft (79%). Unadjusted one-year and three-year survival rates were 85% (95% CI 75 - 92) and 68% (95% CI 56 - 77), respectively.
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| format | Article |
| id | doaj-art-9088ede5e6814ca78bfb20a7afb45e41 |
| institution | Kabale University |
| issn | 0256-9574 2078-5135 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | South African Medical Association |
| record_format | Article |
| series | South African Medical Journal |
| spelling | doaj-art-9088ede5e6814ca78bfb20a7afb45e412025-02-10T12:26:13ZengSouth African Medical AssociationSouth African Medical Journal0256-95742078-51352024-04-011143b10.7196/SAMJ.2024.v114i3b.1365Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantationE U Wessels0K Kinandu1M Beretta2S Berkenfeld3B Bobat4L Brannigan 5R Britz6D Demopoulos7L Doedens8P Gaylard9H Maher10A Mahomed11V Mudau12D Parbhoo13S Rambarran14M Reynders15F van der Schyff 16B Ströbele17J Fabian18J Loveland19Wits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa; Wits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa; Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa; Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaData Management and Statistical Analysis (DMSA), Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa; Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa; Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaWits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa; Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa In 2022, the Wits Transplant Unit performed 57 liver transplants: 33/57 adult (58%) and 24/57 paediatric (42%) recipients. At the beginning of 2022, 28 candidates were on the adult waitlist. Forty-six candidates were added to the waitlist during the year. Sixty-five percent of waitlisted candidate were transplanted. Adult candidates remained on the waitlist for longer than previous years, with 52% of them waitlisted for less than one year before undergoing liver transplantation. There was a decrease in adult pretransplant mortality to 9% in 2021 from 25% in 2020. The most common aetiology in waitlist candidates was alcoholic steatohepatitis (ASH)/non-alcoholic steatohepatitis (NASH) (36%) and in recipients cholestatic (primary sclerosing cholangitis (PSC) and primary biliary sclerosis (PBC)) (40%). Most adult recipients received a deceased donor graft (79%). Unadjusted recipient one- and three-year survivals were 75% (95% confidence interval (CI) 65 - 83) and 74% (95% CI 65 - 81), respectively. In the paediatric population, the most common aetiologies for both pretransplant candidates and transplant recipients remained cholestatic disease and acute liver failure. There was a decrease in paediatric pretransplant mortality from 27% in 2017 to 6% in 2021. Unlike the adult cohort, most paediatric recipients received a living donor graft (79%). Unadjusted one-year and three-year survival rates were 85% (95% CI 75 - 92) and 68% (95% CI 56 - 77), respectively. https://samajournals.co.za/index.php/samj/article/view/1365liver transplantannual reporttransplantationliver |
| spellingShingle | E U Wessels K Kinandu M Beretta S Berkenfeld B Bobat L Brannigan R Britz D Demopoulos L Doedens P Gaylard H Maher A Mahomed V Mudau D Parbhoo S Rambarran M Reynders F van der Schyff B Ströbele J Fabian J Loveland Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation South African Medical Journal liver transplant annual report transplantation liver |
| title | Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation |
| title_full | Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation |
| title_fullStr | Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation |
| title_full_unstemmed | Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation |
| title_short | Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation |
| title_sort | wits transplant unit annual report 2022 adult and paediatric liver transplantation |
| topic | liver transplant annual report transplantation liver |
| url | https://samajournals.co.za/index.php/samj/article/view/1365 |
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