3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study
Abstract Left ventricular (LV) rotational function parameters provide in-depth information about LV mechanical function as well as prognostic information. Using three-dimensional (3D) echocardiography, we identified determinants of LV “twist” and “torsion”, and established reference values using a l...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-024-81662-x |
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| author | Julia Napp Götz Gelbrich Floran Sahiti Vladimir Cejka Dora Pelin Lena Schmidbauer Mengmeng Chen Niklas Hitschrich Marcus Schreckenberg Stefan Frantz Peter U. Heuschmann Stefan Störk Caroline Morbach |
| author_facet | Julia Napp Götz Gelbrich Floran Sahiti Vladimir Cejka Dora Pelin Lena Schmidbauer Mengmeng Chen Niklas Hitschrich Marcus Schreckenberg Stefan Frantz Peter U. Heuschmann Stefan Störk Caroline Morbach |
| author_sort | Julia Napp |
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| description | Abstract Left ventricular (LV) rotational function parameters provide in-depth information about LV mechanical function as well as prognostic information. Using three-dimensional (3D) echocardiography, we identified determinants of LV “twist” and “torsion”, and established reference values using a large population-based cohort. 3D echocardiography images were recorded in n = 2803 subjects within the prospective STAAB cohort study investigating a representative age- and sex-stratified sample of residents of the city of Würzburg, aged 30–79 years, without history of heart failure. Valid 3D image analysis was performed in n = 1831 (65.3%) subjects (mean age 57 ± 11 years, 49.3% women). Using general linear models, we identified determinants of LV twist and torsion: there was a positive association between LV rotational parameters and age, female sex, and blood pressure but a negative association with body weight. From a subset of 479 apparently healthy individuals exhibiting no cardiovascular (CV) risk factors or CV disease (mean age 52 ± 10 years, 56.4% women), we derived reference percentiles for twist and torsion. LV rotation is determined by a complex interplay of sub-endocardial and sub-epicardial fibers which might be affected differentially by potential risk factors. We found a differential association with respective determinants as LV rotational parameters increased with age and with higher blood pressure but decreased with higher body weight. Further research is needed to elucidate these associations in more detail and to determine the additional information contributed by twist and torsion. To facilitate respective attempts and to set an individual’s results in relation to a population-based reference, we derived normal values for twist and torsion from a sub-collective of healthy individuals. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-90ea87b203f04338a80adfada6132bb92025-02-09T12:32:28ZengNature PortfolioScientific Reports2045-23222025-02-0115111410.1038/s41598-024-81662-x3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort studyJulia Napp0Götz Gelbrich1Floran Sahiti2Vladimir Cejka3Dora Pelin4Lena Schmidbauer5Mengmeng Chen6Niklas Hitschrich7Marcus Schreckenberg8Stefan Frantz9Peter U. Heuschmann10Stefan Störk11Caroline Morbach12Academic Core Lab Ultrasound-Based Cardiovascular Imaging, Department Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital WürzburgInstitute of Clinical Epidemiology and Biometry, University of WürzburgAcademic Core Lab Ultrasound-Based Cardiovascular Imaging, Department Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital WürzburgAcademic Core Lab Ultrasound-Based Cardiovascular Imaging, Department Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital WürzburgAcademic Core Lab Ultrasound-Based Cardiovascular Imaging, Department Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital WürzburgInstitute of Clinical Epidemiology and Biometry, University of WürzburgAcademic Core Lab Ultrasound-Based Cardiovascular Imaging, Department Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital WürzburgTOMTEC Imaging Systems GmbHTOMTEC Imaging Systems GmbHAcademic Core Lab Ultrasound-Based Cardiovascular Imaging, Department Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital WürzburgInstitute of Clinical Epidemiology and Biometry, University of WürzburgAcademic Core Lab Ultrasound-Based Cardiovascular Imaging, Department Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital WürzburgAcademic Core Lab Ultrasound-Based Cardiovascular Imaging, Department Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital WürzburgAbstract Left ventricular (LV) rotational function parameters provide in-depth information about LV mechanical function as well as prognostic information. Using three-dimensional (3D) echocardiography, we identified determinants of LV “twist” and “torsion”, and established reference values using a large population-based cohort. 3D echocardiography images were recorded in n = 2803 subjects within the prospective STAAB cohort study investigating a representative age- and sex-stratified sample of residents of the city of Würzburg, aged 30–79 years, without history of heart failure. Valid 3D image analysis was performed in n = 1831 (65.3%) subjects (mean age 57 ± 11 years, 49.3% women). Using general linear models, we identified determinants of LV twist and torsion: there was a positive association between LV rotational parameters and age, female sex, and blood pressure but a negative association with body weight. From a subset of 479 apparently healthy individuals exhibiting no cardiovascular (CV) risk factors or CV disease (mean age 52 ± 10 years, 56.4% women), we derived reference percentiles for twist and torsion. LV rotation is determined by a complex interplay of sub-endocardial and sub-epicardial fibers which might be affected differentially by potential risk factors. We found a differential association with respective determinants as LV rotational parameters increased with age and with higher blood pressure but decreased with higher body weight. Further research is needed to elucidate these associations in more detail and to determine the additional information contributed by twist and torsion. To facilitate respective attempts and to set an individual’s results in relation to a population-based reference, we derived normal values for twist and torsion from a sub-collective of healthy individuals.https://doi.org/10.1038/s41598-024-81662-x3D echocardiographyLeft ventricleTwistTorsionPopulation-based cohort |
| spellingShingle | Julia Napp Götz Gelbrich Floran Sahiti Vladimir Cejka Dora Pelin Lena Schmidbauer Mengmeng Chen Niklas Hitschrich Marcus Schreckenberg Stefan Frantz Peter U. Heuschmann Stefan Störk Caroline Morbach 3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study Scientific Reports 3D echocardiography Left ventricle Twist Torsion Population-based cohort |
| title | 3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study |
| title_full | 3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study |
| title_fullStr | 3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study |
| title_full_unstemmed | 3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study |
| title_short | 3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study |
| title_sort | 3d echocardiography derived reference values and determinants of left ventricular twist and torsion from the population based staab cohort study |
| topic | 3D echocardiography Left ventricle Twist Torsion Population-based cohort |
| url | https://doi.org/10.1038/s41598-024-81662-x |
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