The role of the interleukin family in liver fibrosis
Liver fibrosis represents a wound-healing response to chronic liver injury caused by viral infections, alcohol, and chemicals agents. It is a critical step in the progression from chronic liver disease to cirrhosis and hepatocellular carcinoma. No chemical or biological drugs have been approved for...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1497095/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861119856410624 |
|---|---|
| author | Zixin Zhang Zixin Zhang Jiahui Wang Hui Li Qun Niu Qun Niu Yujing Tao Yujing Tao Xin Zhao Xin Zhao Zijian Zeng Zijian Zeng Haijian Dong Haijian Dong |
| author_facet | Zixin Zhang Zixin Zhang Jiahui Wang Hui Li Qun Niu Qun Niu Yujing Tao Yujing Tao Xin Zhao Xin Zhao Zijian Zeng Zijian Zeng Haijian Dong Haijian Dong |
| author_sort | Zixin Zhang |
| collection | DOAJ |
| description | Liver fibrosis represents a wound-healing response to chronic liver injury caused by viral infections, alcohol, and chemicals agents. It is a critical step in the progression from chronic liver disease to cirrhosis and hepatocellular carcinoma. No chemical or biological drugs have been approved for the treatment of liver fibrosis. Relevant studies have demonstrated that effective inhibition of hepatitis B virus (HBV) replication by nucleoside (acid) analogs or polyethylene glycol alpha-interferon can lead to recovery in some patients with hepatitis B liver fibrosis, However, some patients with liver fibrosis do not show improvement, even after achieving a complete serologic and virologic response. A similar situation occurs in patients with hepatitis C-related liver fibrosis. The liver, with its unique anatomical and immunological structure, is the largest immune organ and produces a large number of cytokines in response to external stimuli, which are crucial for the progression of liver fibrosis. cytokines can act either by directly affecting hepatic stellate cells (HSCs) or by indirectly regulating immune target cells. Among these, the interleukin family activates a complex cascade of responses, including cytokines, chemokines, adhesion molecules, and lipid mediators, playing a key role in the initiation and regulation of inflammation, as well as innate and adaptive immunity. In this paper, we systematically summarize recent literature to elucidate the pathogenesis of interleukin-mediated liver fibrosis and explore potential therapeutic targets for liver fibrosis treatment. |
| format | Article |
| id | doaj-art-91eef386f7c249faba68ab32de9e3bc3 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-91eef386f7c249faba68ab32de9e3bc32025-02-10T05:15:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.14970951497095The role of the interleukin family in liver fibrosisZixin Zhang0Zixin Zhang1Jiahui Wang2Hui Li3Qun Niu4Qun Niu5Yujing Tao6Yujing Tao7Xin Zhao8Xin Zhao9Zijian Zeng10Zijian Zeng11Haijian Dong12Haijian Dong13Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCentral Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCentral Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCentral Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCentral Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCentral Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCentral Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaLiver fibrosis represents a wound-healing response to chronic liver injury caused by viral infections, alcohol, and chemicals agents. It is a critical step in the progression from chronic liver disease to cirrhosis and hepatocellular carcinoma. No chemical or biological drugs have been approved for the treatment of liver fibrosis. Relevant studies have demonstrated that effective inhibition of hepatitis B virus (HBV) replication by nucleoside (acid) analogs or polyethylene glycol alpha-interferon can lead to recovery in some patients with hepatitis B liver fibrosis, However, some patients with liver fibrosis do not show improvement, even after achieving a complete serologic and virologic response. A similar situation occurs in patients with hepatitis C-related liver fibrosis. The liver, with its unique anatomical and immunological structure, is the largest immune organ and produces a large number of cytokines in response to external stimuli, which are crucial for the progression of liver fibrosis. cytokines can act either by directly affecting hepatic stellate cells (HSCs) or by indirectly regulating immune target cells. Among these, the interleukin family activates a complex cascade of responses, including cytokines, chemokines, adhesion molecules, and lipid mediators, playing a key role in the initiation and regulation of inflammation, as well as innate and adaptive immunity. In this paper, we systematically summarize recent literature to elucidate the pathogenesis of interleukin-mediated liver fibrosis and explore potential therapeutic targets for liver fibrosis treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1497095/fullcytokinesinterleukinsinterleukin receptorsinflammationliver fibrosis |
| spellingShingle | Zixin Zhang Zixin Zhang Jiahui Wang Hui Li Qun Niu Qun Niu Yujing Tao Yujing Tao Xin Zhao Xin Zhao Zijian Zeng Zijian Zeng Haijian Dong Haijian Dong The role of the interleukin family in liver fibrosis Frontiers in Immunology cytokines interleukins interleukin receptors inflammation liver fibrosis |
| title | The role of the interleukin family in liver fibrosis |
| title_full | The role of the interleukin family in liver fibrosis |
| title_fullStr | The role of the interleukin family in liver fibrosis |
| title_full_unstemmed | The role of the interleukin family in liver fibrosis |
| title_short | The role of the interleukin family in liver fibrosis |
| title_sort | role of the interleukin family in liver fibrosis |
| topic | cytokines interleukins interleukin receptors inflammation liver fibrosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1497095/full |
| work_keys_str_mv | AT zixinzhang theroleoftheinterleukinfamilyinliverfibrosis AT zixinzhang theroleoftheinterleukinfamilyinliverfibrosis AT jiahuiwang theroleoftheinterleukinfamilyinliverfibrosis AT huili theroleoftheinterleukinfamilyinliverfibrosis AT qunniu theroleoftheinterleukinfamilyinliverfibrosis AT qunniu theroleoftheinterleukinfamilyinliverfibrosis AT yujingtao theroleoftheinterleukinfamilyinliverfibrosis AT yujingtao theroleoftheinterleukinfamilyinliverfibrosis AT xinzhao theroleoftheinterleukinfamilyinliverfibrosis AT xinzhao theroleoftheinterleukinfamilyinliverfibrosis AT zijianzeng theroleoftheinterleukinfamilyinliverfibrosis AT zijianzeng theroleoftheinterleukinfamilyinliverfibrosis AT haijiandong theroleoftheinterleukinfamilyinliverfibrosis AT haijiandong theroleoftheinterleukinfamilyinliverfibrosis AT zixinzhang roleoftheinterleukinfamilyinliverfibrosis AT zixinzhang roleoftheinterleukinfamilyinliverfibrosis AT jiahuiwang roleoftheinterleukinfamilyinliverfibrosis AT huili roleoftheinterleukinfamilyinliverfibrosis AT qunniu roleoftheinterleukinfamilyinliverfibrosis AT qunniu roleoftheinterleukinfamilyinliverfibrosis AT yujingtao roleoftheinterleukinfamilyinliverfibrosis AT yujingtao roleoftheinterleukinfamilyinliverfibrosis AT xinzhao roleoftheinterleukinfamilyinliverfibrosis AT xinzhao roleoftheinterleukinfamilyinliverfibrosis AT zijianzeng roleoftheinterleukinfamilyinliverfibrosis AT zijianzeng roleoftheinterleukinfamilyinliverfibrosis AT haijiandong roleoftheinterleukinfamilyinliverfibrosis AT haijiandong roleoftheinterleukinfamilyinliverfibrosis |