Long-Term Results of the Etiotropic Therapy of Subcompensed Liver Cirrhosis in the Outcome of Chronic Hepatitis C
Aim. The evaluation of long-term results of antiviral therapy (AVT) with ombitasvir/paritaprevir/ritonavir and dasabuvir in patients with noncompensated liver cirrhosis (LC) in the outcome of chronic hepatitis C.Material and methods. A retrospective analysis included the data from patients with subc...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2020-01-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/450 |
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| author | P. O. Bogomolov A. O. Bueverov V. E. Bakirova E. O. Lyusina E. A. Fedosyina S. V. Koblov O. V. Sumtsova |
| author_facet | P. O. Bogomolov A. O. Bueverov V. E. Bakirova E. O. Lyusina E. A. Fedosyina S. V. Koblov O. V. Sumtsova |
| author_sort | P. O. Bogomolov |
| collection | DOAJ |
| description | Aim. The evaluation of long-term results of antiviral therapy (AVT) with ombitasvir/paritaprevir/ritonavir and dasabuvir in patients with noncompensated liver cirrhosis (LC) in the outcome of chronic hepatitis C.Material and methods. A retrospective analysis included the data from patients with subcompensated liver cirrhosis (LC) of HCV etiology (genotype 1b) (7–9 points of the Child-Pugh score) having received interferon-free antiviral therapy (AVT) with ombitasvir/paritaprevir/ritonavir and dasabuvir during 12 weeks from September to December 2015. In total, 66 patients (27 men and 39 women) received such a therapy, the median age was 56.4 years.Results. 147 weeks (IQR 56–156) following AVT completion, the long-term results were evaluated. At that time, 27 patients were available for observation. The assessment of liver function compensation using the Child-Pugh score showed improvement in 25 (93 %) patients. The assessment of laboratory data revealed a decrease in the median of total bilirubin by 13.6 μmol/l, as well as an increase in the median of serum albumin by 9.7 g/L and the median of platelets by 41,700/μl. Two deaths were reported due to hepatocellular cancer (HCC) and bleeding from esophageal varices. HCC was detected in 8 patients. Two patients underwent liver transplantation.Conclusion. AVT in patients with LC of HCV etiology is associated with a high frequency of virologic response. Longterm follow-up results indicate a significant improvement of liver function, but also a continuing high risk of developing complications of underlying disease, primarily HCC. |
| format | Article |
| id | doaj-art-924ab91772984d3babfd262fe94cc828 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2020-01-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-924ab91772984d3babfd262fe94cc8282025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732020-01-01296303510.22416/1382-4376-2019-29-6-30-35335Long-Term Results of the Etiotropic Therapy of Subcompensed Liver Cirrhosis in the Outcome of Chronic Hepatitis CP. O. Bogomolov0A. O. Bueverov1V. E. Bakirova2E. O. Lyusina3E. A. Fedosyina4S. V. Koblov5O. V. Sumtsova6M.F. Vladimirsky Moscow Regional Research and Clinical Institute (MONIKI)I.M. Sechenov First Moscow State Medical University (Sechenov University), M.F. Vladimirsky Moscow Regional Research and Clinical Institute (MONIKI).M.F. Vladimirsky Moscow Regional Research and Clinical Institute (MONIKI)M.F. Vladimirsky Moscow Regional Research and Clinical Institute (MONIKI)M.F. Vladimirsky Moscow Regional Research and Clinical Institute (MONIKI)M.F. Vladimirsky Moscow Regional Research and Clinical Institute (MONIKI)M.F. Vladimirsky Moscow Regional Research and Clinical Institute (MONIKI)Aim. The evaluation of long-term results of antiviral therapy (AVT) with ombitasvir/paritaprevir/ritonavir and dasabuvir in patients with noncompensated liver cirrhosis (LC) in the outcome of chronic hepatitis C.Material and methods. A retrospective analysis included the data from patients with subcompensated liver cirrhosis (LC) of HCV etiology (genotype 1b) (7–9 points of the Child-Pugh score) having received interferon-free antiviral therapy (AVT) with ombitasvir/paritaprevir/ritonavir and dasabuvir during 12 weeks from September to December 2015. In total, 66 patients (27 men and 39 women) received such a therapy, the median age was 56.4 years.Results. 147 weeks (IQR 56–156) following AVT completion, the long-term results were evaluated. At that time, 27 patients were available for observation. The assessment of liver function compensation using the Child-Pugh score showed improvement in 25 (93 %) patients. The assessment of laboratory data revealed a decrease in the median of total bilirubin by 13.6 μmol/l, as well as an increase in the median of serum albumin by 9.7 g/L and the median of platelets by 41,700/μl. Two deaths were reported due to hepatocellular cancer (HCC) and bleeding from esophageal varices. HCC was detected in 8 patients. Two patients underwent liver transplantation.Conclusion. AVT in patients with LC of HCV etiology is associated with a high frequency of virologic response. Longterm follow-up results indicate a significant improvement of liver function, but also a continuing high risk of developing complications of underlying disease, primarily HCC.https://www.gastro-j.ru/jour/article/view/450chronic hepatitis cliver cirrhosistreatmentlong-term results |
| spellingShingle | P. O. Bogomolov A. O. Bueverov V. E. Bakirova E. O. Lyusina E. A. Fedosyina S. V. Koblov O. V. Sumtsova Long-Term Results of the Etiotropic Therapy of Subcompensed Liver Cirrhosis in the Outcome of Chronic Hepatitis C Российский журнал гастроэнтерологии, гепатологии, колопроктологии chronic hepatitis c liver cirrhosis treatment long-term results |
| title | Long-Term Results of the Etiotropic Therapy of Subcompensed Liver Cirrhosis in the Outcome of Chronic Hepatitis C |
| title_full | Long-Term Results of the Etiotropic Therapy of Subcompensed Liver Cirrhosis in the Outcome of Chronic Hepatitis C |
| title_fullStr | Long-Term Results of the Etiotropic Therapy of Subcompensed Liver Cirrhosis in the Outcome of Chronic Hepatitis C |
| title_full_unstemmed | Long-Term Results of the Etiotropic Therapy of Subcompensed Liver Cirrhosis in the Outcome of Chronic Hepatitis C |
| title_short | Long-Term Results of the Etiotropic Therapy of Subcompensed Liver Cirrhosis in the Outcome of Chronic Hepatitis C |
| title_sort | long term results of the etiotropic therapy of subcompensed liver cirrhosis in the outcome of chronic hepatitis c |
| topic | chronic hepatitis c liver cirrhosis treatment long-term results |
| url | https://www.gastro-j.ru/jour/article/view/450 |
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