Case report of glomerular histiocytosis associated with non-crystalline IgG-kappa paraproteinemia
Abstract Background Monoclonal gammopathy of renal significance (MGRS) represents a range of disease processes arising from monoclonal proteins depositing in the kidney. These deposits vary and can be broadly grouped as containing a substructure or being non-organised. Their clinical phenotype can i...
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BMC
2025-02-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-025-03986-8 |
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| author | Aditya Kishore Susanna A. McRae David Telio Monica C. Beaulieu |
| author_facet | Aditya Kishore Susanna A. McRae David Telio Monica C. Beaulieu |
| author_sort | Aditya Kishore |
| collection | DOAJ |
| description | Abstract Background Monoclonal gammopathy of renal significance (MGRS) represents a range of disease processes arising from monoclonal proteins depositing in the kidney. These deposits vary and can be broadly grouped as containing a substructure or being non-organised. Their clinical phenotype can include proteinuria, haematuria, kidney injury and tubulopathies resulting in electrolyte changes. Case presentation Crystal storing histiocytosis (CSH) is a rare form of MGRS that typically deposits in the interstitium but rarely in the glomerulus to cause progressive kidney disease. We report a case of a male with known monoclonal protein and progressive proteinuria, whose biopsy showed glomerular histiocytosis with non-crystallizing IgG kappa inclusions. Conclusion This case reviews an unusual case of a glomerular histiocytosis with non-crystallizing IgG kappa inclusions. |
| format | Article |
| id | doaj-art-94409c5c3bd74dcf97ddf8cd8fb100d1 |
| institution | Kabale University |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-94409c5c3bd74dcf97ddf8cd8fb100d12025-02-09T12:16:51ZengBMCBMC Nephrology1471-23692025-02-012611610.1186/s12882-025-03986-8Case report of glomerular histiocytosis associated with non-crystalline IgG-kappa paraproteinemiaAditya Kishore0Susanna A. McRae1David Telio2Monica C. Beaulieu3Division of Nephrology, University of British ColumbiaDepartment of Pathology and Laboratory Medicine, Providence Health Care, St Paul’s HospitalDivision of Medical Oncology, Burnaby Hospital, Fraser Health AuthorityDivision of Nephrology, University of British ColumbiaAbstract Background Monoclonal gammopathy of renal significance (MGRS) represents a range of disease processes arising from monoclonal proteins depositing in the kidney. These deposits vary and can be broadly grouped as containing a substructure or being non-organised. Their clinical phenotype can include proteinuria, haematuria, kidney injury and tubulopathies resulting in electrolyte changes. Case presentation Crystal storing histiocytosis (CSH) is a rare form of MGRS that typically deposits in the interstitium but rarely in the glomerulus to cause progressive kidney disease. We report a case of a male with known monoclonal protein and progressive proteinuria, whose biopsy showed glomerular histiocytosis with non-crystallizing IgG kappa inclusions. Conclusion This case reviews an unusual case of a glomerular histiocytosis with non-crystallizing IgG kappa inclusions.https://doi.org/10.1186/s12882-025-03986-8Crystal storing histiocytosisGlomerular histiocytosisMonoclonal gammopathy of renal significance |
| spellingShingle | Aditya Kishore Susanna A. McRae David Telio Monica C. Beaulieu Case report of glomerular histiocytosis associated with non-crystalline IgG-kappa paraproteinemia BMC Nephrology Crystal storing histiocytosis Glomerular histiocytosis Monoclonal gammopathy of renal significance |
| title | Case report of glomerular histiocytosis associated with non-crystalline IgG-kappa paraproteinemia |
| title_full | Case report of glomerular histiocytosis associated with non-crystalline IgG-kappa paraproteinemia |
| title_fullStr | Case report of glomerular histiocytosis associated with non-crystalline IgG-kappa paraproteinemia |
| title_full_unstemmed | Case report of glomerular histiocytosis associated with non-crystalline IgG-kappa paraproteinemia |
| title_short | Case report of glomerular histiocytosis associated with non-crystalline IgG-kappa paraproteinemia |
| title_sort | case report of glomerular histiocytosis associated with non crystalline igg kappa paraproteinemia |
| topic | Crystal storing histiocytosis Glomerular histiocytosis Monoclonal gammopathy of renal significance |
| url | https://doi.org/10.1186/s12882-025-03986-8 |
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