Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis
COVID-19 is the deadly respiratory disease of the century caused by new type unknown origin Coronavirus. The recent effort of the word researchers is toward finding the origin of the virus. The current study investigated the extent of molecular similarity and divergence between SARS-CoV2 and other r...
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| Format: | Article |
| Language: | English |
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Sulaimani Polytechnic University
2020-12-01
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| Series: | Kurdistan Journal of Applied Research |
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| Online Access: | https://kjar.spu.edu.iq/index.php/kjar/article/view/571 |
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| author | Salvatore Dimonte Paywast Jamal Jalal Hiwa Abdulrahman Ahmad Safa Bakr Karim Taib Ahmed Hama Soor Salar Ibrahim Ali Muhammed Babakir-Mina Francesco Greco |
| author_facet | Salvatore Dimonte Paywast Jamal Jalal Hiwa Abdulrahman Ahmad Safa Bakr Karim Taib Ahmed Hama Soor Salar Ibrahim Ali Muhammed Babakir-Mina Francesco Greco |
| author_sort | Salvatore Dimonte |
| collection | DOAJ |
| description | COVID-19 is the deadly respiratory disease of the century caused by new type unknown origin Coronavirus. The recent effort of the word researchers is toward finding the origin of the virus. The current study investigated the extent of molecular similarity and divergence between SARS-CoV2 and other related Coronavirus. An attempt has been made to investigate the epidemiological study of this new contagious virus using molecular biology techniques. The phylogenetic trees for all human coronaviruses with the novel Coronavirus have been built using a several complete amino acid sequences of the four known structural proteins, S (spike), E (envelope), M (membrane), and N (nucleocapsid). The result of the study revealed that the SARS-CoV2 is related to human SARS-CoV isolated from different countries very cloely, especially those strains recovered from China in recent times, 2020. The evolutionary changes observed in the inserted 23 amino acids in the RNA binding domain (RBD) of the coronvirus spike glycoprotein which cannot be detected in any other human coronavirus. Moreover, the 2019-nCoV is not closely related to other alpha, beta and gamma human Coronavirus, including MERS-CoV. The current study concluded that 2019-nCoV is more likely believed to originated from SARS-CoV. The probability is more vital to be originated from the strain isolated in China in 2020, which is coincident with the spraed of COVID-19 in the same country. The phyloepidemiologic analyses suggested that the coronaviruses are circulating in human hosts evolving gradually by times in response to the different environment stimuli facing the virus inside the host in different geographical areas. Furthermore, the analysis showed the flow of transmission, and evolutionary changes of SARS-CoV2 which may be directed from the transmission of SARS-CoV from human to Bat and Pangolin then jumped to human again in the crowded market Wuhan city in China.
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| format | Article |
| id | doaj-art-945c65c5f7d94b2e8859444a7c45b33e |
| institution | Kabale University |
| issn | 2411-7684 2411-7706 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Sulaimani Polytechnic University |
| record_format | Article |
| series | Kurdistan Journal of Applied Research |
| spelling | doaj-art-945c65c5f7d94b2e8859444a7c45b33e2025-02-09T21:00:02ZengSulaimani Polytechnic UniversityKurdistan Journal of Applied Research2411-76842411-77062020-12-016310.24017/science.2020.ICHMS2020.19Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic AnalysisSalvatore Dimonte0Paywast Jamal Jalal1Hiwa Abdulrahman Ahmad2Safa Bakr Karim3Taib Ahmed Hama Soor4Salar Ibrahim Ali5Muhammed Babakir-Mina6Francesco Greco7BioMolecular Lab, ItalyBiology Department, College of Science, University of Sulaimani, Sulaimani, IraqScience and Health Research Center, Faculty of Science and Health, Koya University, Koya, IraqAnesthesia Department, Technical College of Health, Sulaimani Polytechnic University, Sulaimani, IraqMedical Laboratory Department, Technical College of Health, Sulaimani Polytechnic University, Sulaimani, IraqNursing Department, Technical College of Health , Sulaimani Polytechnic University , Sulaimani, IraqMedical Laboratory Department, Technical College of Health, Sulaimani Polytechnic University, Sulaimani, IraqDepartment of Intensive Care Medicine and Neonatology, University Children's Hospital, Zurich, SwitzerlandCOVID-19 is the deadly respiratory disease of the century caused by new type unknown origin Coronavirus. The recent effort of the word researchers is toward finding the origin of the virus. The current study investigated the extent of molecular similarity and divergence between SARS-CoV2 and other related Coronavirus. An attempt has been made to investigate the epidemiological study of this new contagious virus using molecular biology techniques. The phylogenetic trees for all human coronaviruses with the novel Coronavirus have been built using a several complete amino acid sequences of the four known structural proteins, S (spike), E (envelope), M (membrane), and N (nucleocapsid). The result of the study revealed that the SARS-CoV2 is related to human SARS-CoV isolated from different countries very cloely, especially those strains recovered from China in recent times, 2020. The evolutionary changes observed in the inserted 23 amino acids in the RNA binding domain (RBD) of the coronvirus spike glycoprotein which cannot be detected in any other human coronavirus. Moreover, the 2019-nCoV is not closely related to other alpha, beta and gamma human Coronavirus, including MERS-CoV. The current study concluded that 2019-nCoV is more likely believed to originated from SARS-CoV. The probability is more vital to be originated from the strain isolated in China in 2020, which is coincident with the spraed of COVID-19 in the same country. The phyloepidemiologic analyses suggested that the coronaviruses are circulating in human hosts evolving gradually by times in response to the different environment stimuli facing the virus inside the host in different geographical areas. Furthermore, the analysis showed the flow of transmission, and evolutionary changes of SARS-CoV2 which may be directed from the transmission of SARS-CoV from human to Bat and Pangolin then jumped to human again in the crowded market Wuhan city in China. https://kjar.spu.edu.iq/index.php/kjar/article/view/571SARS-CoV2, SARS-CoV, MERS-CoV, COVID-19 and 2019-nCoV |
| spellingShingle | Salvatore Dimonte Paywast Jamal Jalal Hiwa Abdulrahman Ahmad Safa Bakr Karim Taib Ahmed Hama Soor Salar Ibrahim Ali Muhammed Babakir-Mina Francesco Greco Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis Kurdistan Journal of Applied Research SARS-CoV2, SARS-CoV, MERS-CoV, COVID-19 and 2019-nCoV |
| title | Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis |
| title_full | Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis |
| title_fullStr | Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis |
| title_full_unstemmed | Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis |
| title_short | Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis |
| title_sort | is the sars cov2 evolved in human being a prospective genetic analysis |
| topic | SARS-CoV2, SARS-CoV, MERS-CoV, COVID-19 and 2019-nCoV |
| url | https://kjar.spu.edu.iq/index.php/kjar/article/view/571 |
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