Relationship between Schlemm’s canal incision length and the results of ab interno gonioscopy-assisted transluminal suture trabeculotomy
Abstract We retrospectively investigated the relationship between Schlemm’s canal incision length and the results of ab interno gonioscopy-assisted transluminal suture trabeculotomy (GATST) with/without cataract surgery in open-angle glaucoma patients at Tsukazaki Hospital from 2018–2021. The study...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88479-2 |
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| author | Hirotaka Tanabe Shunsuke Nakakura Kazuaki Nishimura Etsuko Terao Yasuko Fujisawa Yuki Nagata Satomi Oogi Miku Adachi Kanae Matsuya |
| author_facet | Hirotaka Tanabe Shunsuke Nakakura Kazuaki Nishimura Etsuko Terao Yasuko Fujisawa Yuki Nagata Satomi Oogi Miku Adachi Kanae Matsuya |
| author_sort | Hirotaka Tanabe |
| collection | DOAJ |
| description | Abstract We retrospectively investigated the relationship between Schlemm’s canal incision length and the results of ab interno gonioscopy-assisted transluminal suture trabeculotomy (GATST) with/without cataract surgery in open-angle glaucoma patients at Tsukazaki Hospital from 2018–2021. The study included 113 eyes from 76 patients (age: 70.0 ± 10.8 years; female/male: 43 [56.6%]/33 [43.4%]). GATST with and without cataract surgery was performed on 87 (phakia) [77.0%] and 26 eyes (pseudophakia) [23.0%], respectively; 102 [90.3%] eyes had primary open-angle glaucoma, and 11 [9.7%] had pseudoexfoliation glaucoma. Intraocular pressure (IOP) significantly decreased at 3/6/12 months, and the antiglaucoma eyedrop number significantly decreased at 6/12 months (all P values < 0.001). Linear mixed-effects models showed that incision length had significant positive associations with IOP spikes, hyphema grade, and IOP changes (amount/percentage) at 6 months; surgical success rate (IOP ≤ 15 mmHg, ≥ 20% reduction, no additional surgeries [criterion B]) at 6/12 months; and surgical success rate (IOP ≤ 21 mmHg, ≥ 20% reduction, no additional surgeries [criterion A]) at 12 months (Ps < 0.05). There were no significant associations with IOP changes at 12 months, surgical success rate (criterion A) at 6 months, or antiglaucoma eyedrop number at either timepoint (Ps > 0.05). Longer incisions were more likely to produce greater IOP reduction, requiring more attention to IOP spikes/hyphema. |
| format | Article |
| id | doaj-art-947c3b20cb504078bb4c2ddef10ce08c |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-947c3b20cb504078bb4c2ddef10ce08c2025-02-09T12:31:34ZengNature PortfolioScientific Reports2045-23222025-02-0115111010.1038/s41598-025-88479-2Relationship between Schlemm’s canal incision length and the results of ab interno gonioscopy-assisted transluminal suture trabeculotomyHirotaka Tanabe0Shunsuke Nakakura1Kazuaki Nishimura2Etsuko Terao3Yasuko Fujisawa4Yuki Nagata5Satomi Oogi6Miku Adachi7Kanae Matsuya8Department of Ophthalmology, Yokkaichi Digestive Disease CenterDepartment of Ophthalmology, Tsukazaki HospitalDepartment of Ophthalmology, Tsukazaki HospitalDepartment of Ophthalmology, Tsukazaki HospitalDepartment of Ophthalmology, Tsukazaki HospitalDepartment of Ophthalmology, Tsukazaki HospitalDepartment of Ophthalmology, Tsukazaki HospitalDepartment of Ophthalmology, Tsukazaki HospitalDepartment of Ophthalmology, Tsukazaki HospitalAbstract We retrospectively investigated the relationship between Schlemm’s canal incision length and the results of ab interno gonioscopy-assisted transluminal suture trabeculotomy (GATST) with/without cataract surgery in open-angle glaucoma patients at Tsukazaki Hospital from 2018–2021. The study included 113 eyes from 76 patients (age: 70.0 ± 10.8 years; female/male: 43 [56.6%]/33 [43.4%]). GATST with and without cataract surgery was performed on 87 (phakia) [77.0%] and 26 eyes (pseudophakia) [23.0%], respectively; 102 [90.3%] eyes had primary open-angle glaucoma, and 11 [9.7%] had pseudoexfoliation glaucoma. Intraocular pressure (IOP) significantly decreased at 3/6/12 months, and the antiglaucoma eyedrop number significantly decreased at 6/12 months (all P values < 0.001). Linear mixed-effects models showed that incision length had significant positive associations with IOP spikes, hyphema grade, and IOP changes (amount/percentage) at 6 months; surgical success rate (IOP ≤ 15 mmHg, ≥ 20% reduction, no additional surgeries [criterion B]) at 6/12 months; and surgical success rate (IOP ≤ 21 mmHg, ≥ 20% reduction, no additional surgeries [criterion A]) at 12 months (Ps < 0.05). There were no significant associations with IOP changes at 12 months, surgical success rate (criterion A) at 6 months, or antiglaucoma eyedrop number at either timepoint (Ps > 0.05). Longer incisions were more likely to produce greater IOP reduction, requiring more attention to IOP spikes/hyphema.https://doi.org/10.1038/s41598-025-88479-2Minimally invasive or microinvasive glaucoma surgery (MIGS)Schlemm’s canal incision lengthAb interno gonioscopy-assisted transluminal suture trabeculotomy (GATST)Open-angle glaucoma |
| spellingShingle | Hirotaka Tanabe Shunsuke Nakakura Kazuaki Nishimura Etsuko Terao Yasuko Fujisawa Yuki Nagata Satomi Oogi Miku Adachi Kanae Matsuya Relationship between Schlemm’s canal incision length and the results of ab interno gonioscopy-assisted transluminal suture trabeculotomy Scientific Reports Minimally invasive or microinvasive glaucoma surgery (MIGS) Schlemm’s canal incision length Ab interno gonioscopy-assisted transluminal suture trabeculotomy (GATST) Open-angle glaucoma |
| title | Relationship between Schlemm’s canal incision length and the results of ab interno gonioscopy-assisted transluminal suture trabeculotomy |
| title_full | Relationship between Schlemm’s canal incision length and the results of ab interno gonioscopy-assisted transluminal suture trabeculotomy |
| title_fullStr | Relationship between Schlemm’s canal incision length and the results of ab interno gonioscopy-assisted transluminal suture trabeculotomy |
| title_full_unstemmed | Relationship between Schlemm’s canal incision length and the results of ab interno gonioscopy-assisted transluminal suture trabeculotomy |
| title_short | Relationship between Schlemm’s canal incision length and the results of ab interno gonioscopy-assisted transluminal suture trabeculotomy |
| title_sort | relationship between schlemm s canal incision length and the results of ab interno gonioscopy assisted transluminal suture trabeculotomy |
| topic | Minimally invasive or microinvasive glaucoma surgery (MIGS) Schlemm’s canal incision length Ab interno gonioscopy-assisted transluminal suture trabeculotomy (GATST) Open-angle glaucoma |
| url | https://doi.org/10.1038/s41598-025-88479-2 |
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