Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner
Abstract Purpose 18F-labelled somatostatin receptor tracers have recently gained popularity due to their better spatial resolution, longer half-life and lower costs compared to 68Ga-labeled tracers. The aim of this study was to evaluate the impact and limitations of reduced administered activities o...
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SpringerOpen
2025-02-01
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| Series: | EJNMMI Physics |
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| Online Access: | https://doi.org/10.1186/s40658-025-00720-z |
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| author | Nils F. Trautwein Eduardo Calderón Pia M. Linder Gerald Reischl Philippe Driessen Wenhong Lan Andreas S. Brendlin Thorben Groß Helmut Dittmann Martina Hinterleitner Christian la Fougère Fabian P. Schmidt Lena S. Kiefer |
| author_facet | Nils F. Trautwein Eduardo Calderón Pia M. Linder Gerald Reischl Philippe Driessen Wenhong Lan Andreas S. Brendlin Thorben Groß Helmut Dittmann Martina Hinterleitner Christian la Fougère Fabian P. Schmidt Lena S. Kiefer |
| author_sort | Nils F. Trautwein |
| collection | DOAJ |
| description | Abstract Purpose 18F-labelled somatostatin receptor tracers have recently gained popularity due to their better spatial resolution, longer half-life and lower costs compared to 68Ga-labeled tracers. The aim of this study was to evaluate the impact and limitations of reduced administered activities of [18F]SiTATE on image quality, lesion detectability and quantitative PET parameters in a long axial field-of-view (LAFOV) PET/CT scanner. Methods Twenty-four patients with histologically confirmed neuroendocrine tumor, who underwent clinically indicated [18F]SiTATE PET/CT examination (3.0 MBq/kg, 5 min PET scan time) on a Siemens Biograph Vision Quadra LAFOV PET/CT, were included retrospectively in this study. PET list-mode data were rebinned for shorter frame durations to simulate 5 min scans with lower activities of injected radiotracer. A comparison of image reconstruction in high sensitivity (HS) and ultra-high sensitivity mode (UHS) mode was performed. Subjective image quality, noise and lesion detectability of n = 122 lesions were rated using a 5-point Likert scale. The molecular tumor volume (MTV), signal-to-noise ratio (SNR), tumor-to-liver activity concentration ratio (TLR) and standardized uptake values (SUV) were analyzed. Results Subjective image quality decreased with simulated reduction of injected activity with generally superior ratings in the UHS mode compared to the HS mode. Despite a reduction to 1 MBq/kg of [18F]SiTATE all lesions were still detected while at 0.25 MBq/kg lesion detectability decreased to 70% (HS) and 93% (UHS). Only minor changes in SUVmean and TLR were detected with reduced activity. However, reduced activities led to an increase in SUVSD, which in turn caused a decrease in SNR (at 1 MBq/kg: 7.3 in HS and 9.0 in UHS mode and an increase in deviation of the MTV. Conclusion Reducing the administered activity of injected [18F]SiTATE by 66% to 1 MBq/kg (HS & UHS) is feasible in a LAFOV PET/CT scanner, maintaining clinically diagnostic image quality without statistically significant deviations in PET uptake parameters and MTV. Furthermore, in low activity [18F]SiTATE PET/CT, the UHS mode improves image quality and noise as well as lesion detectability compared to HS mode, further reinforcing the clinical benefits of this recently introduced reconstruction mode. |
| format | Article |
| id | doaj-art-94cbbb18dec4411ca6ade75df5d75ee3 |
| institution | Kabale University |
| issn | 2197-7364 |
| language | English |
| publishDate | 2025-02-01 |
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| series | EJNMMI Physics |
| spelling | doaj-art-94cbbb18dec4411ca6ade75df5d75ee32025-02-09T12:54:49ZengSpringerOpenEJNMMI Physics2197-73642025-02-0112111510.1186/s40658-025-00720-zLow-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scannerNils F. Trautwein0Eduardo Calderón1Pia M. Linder2Gerald Reischl3Philippe Driessen4Wenhong Lan5Andreas S. Brendlin6Thorben Groß7Helmut Dittmann8Martina Hinterleitner9Christian la Fougère10Fabian P. Schmidt11Lena S. Kiefer12Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital TuebingenDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital TuebingenDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital TuebingenWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University TuebingenDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital TuebingenDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital TuebingenDepartment of Diagnostic and Interventional Radiology, University Hospital TuebingenDepartment of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital TuebingenDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital TuebingenENETS Center of Excellence, University Hospital TuebingenDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital TuebingenDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital TuebingenDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital TuebingenAbstract Purpose 18F-labelled somatostatin receptor tracers have recently gained popularity due to their better spatial resolution, longer half-life and lower costs compared to 68Ga-labeled tracers. The aim of this study was to evaluate the impact and limitations of reduced administered activities of [18F]SiTATE on image quality, lesion detectability and quantitative PET parameters in a long axial field-of-view (LAFOV) PET/CT scanner. Methods Twenty-four patients with histologically confirmed neuroendocrine tumor, who underwent clinically indicated [18F]SiTATE PET/CT examination (3.0 MBq/kg, 5 min PET scan time) on a Siemens Biograph Vision Quadra LAFOV PET/CT, were included retrospectively in this study. PET list-mode data were rebinned for shorter frame durations to simulate 5 min scans with lower activities of injected radiotracer. A comparison of image reconstruction in high sensitivity (HS) and ultra-high sensitivity mode (UHS) mode was performed. Subjective image quality, noise and lesion detectability of n = 122 lesions were rated using a 5-point Likert scale. The molecular tumor volume (MTV), signal-to-noise ratio (SNR), tumor-to-liver activity concentration ratio (TLR) and standardized uptake values (SUV) were analyzed. Results Subjective image quality decreased with simulated reduction of injected activity with generally superior ratings in the UHS mode compared to the HS mode. Despite a reduction to 1 MBq/kg of [18F]SiTATE all lesions were still detected while at 0.25 MBq/kg lesion detectability decreased to 70% (HS) and 93% (UHS). Only minor changes in SUVmean and TLR were detected with reduced activity. However, reduced activities led to an increase in SUVSD, which in turn caused a decrease in SNR (at 1 MBq/kg: 7.3 in HS and 9.0 in UHS mode and an increase in deviation of the MTV. Conclusion Reducing the administered activity of injected [18F]SiTATE by 66% to 1 MBq/kg (HS & UHS) is feasible in a LAFOV PET/CT scanner, maintaining clinically diagnostic image quality without statistically significant deviations in PET uptake parameters and MTV. Furthermore, in low activity [18F]SiTATE PET/CT, the UHS mode improves image quality and noise as well as lesion detectability compared to HS mode, further reinforcing the clinical benefits of this recently introduced reconstruction mode.https://doi.org/10.1186/s40658-025-00720-zLAFOV PET/CTTotal-Body-PET[18F]SiTATELow-activity [18F]SiTATE PET[18F]-SSTR imaging |
| spellingShingle | Nils F. Trautwein Eduardo Calderón Pia M. Linder Gerald Reischl Philippe Driessen Wenhong Lan Andreas S. Brendlin Thorben Groß Helmut Dittmann Martina Hinterleitner Christian la Fougère Fabian P. Schmidt Lena S. Kiefer Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner EJNMMI Physics LAFOV PET/CT Total-Body-PET [18F]SiTATE Low-activity [18F]SiTATE PET [18F]-SSTR imaging |
| title | Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner |
| title_full | Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner |
| title_fullStr | Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner |
| title_full_unstemmed | Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner |
| title_short | Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner |
| title_sort | low activity 18f somatostatin receptor sstr imaging using 18f sitate on a long axial field of view pet ct scanner |
| topic | LAFOV PET/CT Total-Body-PET [18F]SiTATE Low-activity [18F]SiTATE PET [18F]-SSTR imaging |
| url | https://doi.org/10.1186/s40658-025-00720-z |
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