Prognostic value of serum cystatin C in patients with sepsis
Background: Early identification and diagnosis of sepsis are very important because timely and appropriate treatment can improve the survival outcomes. Aim: The aim of this study was to explore the clinical significance of serum cystatin C level in sepsis. Materials and Methods: The levels of serum c...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-07-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_804_21 |
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| _version_ | 1825206169371672576 |
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| author | Chunfang Hu Zhiyuan Zhang Bin Hou Han Xue Xuehua Pu Jilu Ye |
| author_facet | Chunfang Hu Zhiyuan Zhang Bin Hou Han Xue Xuehua Pu Jilu Ye |
| author_sort | Chunfang Hu |
| collection | DOAJ |
| description | Background:
Early identification and diagnosis of sepsis are very important because timely and appropriate treatment can improve the survival outcomes.
Aim:
The aim of this study was to explore the clinical significance of serum cystatin C level in sepsis.
Materials and Methods:
The levels of serum cystatin C, C-reactive protein (CRP), and procalcitonin (PCT) were measured via enzyme-linked immunosorbent assay (ELISA). The patients with sepsis were followed up for 30 days to record their survival conditions.
Results:
The expression level of cystatin C was remarkably elevated in patients with sepsis compared with that in healthy controls. The serum cystatin C level was significantly correlated with the SOFA score and CRP, PCT, and creatinine levels in patients with sepsis. The patients in death group had a markedly higher level of serum cystatin C than those in survival group. The area under curve (AUC) of cystatin C for assessing the 30-day mortality rate of sepsis patients was 0.765.
Conclusion:
The serum cystatin C level is elevated in patients with sepsis and it may serve as a biomarker for early diagnosis of sepsis and possess promising effects in assessing the severity of sepsis and the prognosis of patients. |
| format | Article |
| id | doaj-art-957506dd73e841e4aada26c9a46bc00a |
| institution | Kabale University |
| issn | 0377-4929 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-957506dd73e841e4aada26c9a46bc00a2025-02-07T13:32:20ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292023-07-0166357357610.4103/ijpm.ijpm_804_21Prognostic value of serum cystatin C in patients with sepsisChunfang HuZhiyuan ZhangBin HouHan XueXuehua PuJilu YeBackground: Early identification and diagnosis of sepsis are very important because timely and appropriate treatment can improve the survival outcomes. Aim: The aim of this study was to explore the clinical significance of serum cystatin C level in sepsis. Materials and Methods: The levels of serum cystatin C, C-reactive protein (CRP), and procalcitonin (PCT) were measured via enzyme-linked immunosorbent assay (ELISA). The patients with sepsis were followed up for 30 days to record their survival conditions. Results: The expression level of cystatin C was remarkably elevated in patients with sepsis compared with that in healthy controls. The serum cystatin C level was significantly correlated with the SOFA score and CRP, PCT, and creatinine levels in patients with sepsis. The patients in death group had a markedly higher level of serum cystatin C than those in survival group. The area under curve (AUC) of cystatin C for assessing the 30-day mortality rate of sepsis patients was 0.765. Conclusion: The serum cystatin C level is elevated in patients with sepsis and it may serve as a biomarker for early diagnosis of sepsis and possess promising effects in assessing the severity of sepsis and the prognosis of patients.https://journals.lww.com/10.4103/ijpm.ijpm_804_21cystatin cdiagnosisprognosissepsis |
| spellingShingle | Chunfang Hu Zhiyuan Zhang Bin Hou Han Xue Xuehua Pu Jilu Ye Prognostic value of serum cystatin C in patients with sepsis Indian Journal of Pathology and Microbiology cystatin c diagnosis prognosis sepsis |
| title | Prognostic value of serum cystatin C in patients with sepsis |
| title_full | Prognostic value of serum cystatin C in patients with sepsis |
| title_fullStr | Prognostic value of serum cystatin C in patients with sepsis |
| title_full_unstemmed | Prognostic value of serum cystatin C in patients with sepsis |
| title_short | Prognostic value of serum cystatin C in patients with sepsis |
| title_sort | prognostic value of serum cystatin c in patients with sepsis |
| topic | cystatin c diagnosis prognosis sepsis |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_804_21 |
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