Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study
BackgroundThe prevalence of overactive bladder (OAB) is increasing in the elderly population and there is growing evidence that malnutrition affects the urinary system. Despite this, research on the relationship between nutritional factors and OAB remains limited.MethodsWe included 17,161 elderly in...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1537549/full |
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| author | Wei Zheng Wei Zheng Chuanzan Zhou Jia Miao Yunkai Yang Xuanhan Hu Heng Wang Xinyu Zhang Qi Zhang Yifan Wang |
| author_facet | Wei Zheng Wei Zheng Chuanzan Zhou Jia Miao Yunkai Yang Xuanhan Hu Heng Wang Xinyu Zhang Qi Zhang Yifan Wang |
| author_sort | Wei Zheng |
| collection | DOAJ |
| description | BackgroundThe prevalence of overactive bladder (OAB) is increasing in the elderly population and there is growing evidence that malnutrition affects the urinary system. Despite this, research on the relationship between nutritional factors and OAB remains limited.MethodsWe included 17,161 elderly individuals from the National Health and Nutrition Examination Survey conducted between 2005 and 2018. Overactive Bladder Symptom Scores (OABSS) were utilized to assess symptoms of OAB. A multifactorial logistic regression analysis was employed to evaluate the independent association between the Geriatric Nutritional Risk Index (GNRI) and the prevalence of OAB. Restricted cubic spline plots examined the potential non-linear relationship between GNRI and OAB. Influencing factors were assessed through subgroup analyses, while the predictive utility of GNRI was assessed with receiver operating characteristic (ROC) curves. The influence of inflammatory response and cognitive function on the interaction between GNRI and OAB was also examined by mediation analysis.ResultsGNRI in the OAB group was significantly lower than that in the non-OAB group. Multifactorial logistic regression analysis revealed that GNRI significantly predicts OAB (p < 0.05). The Restricted Cubic Spline (RCS) curve indicated a non-linear negative correlation between GNRI and the risk of OAB in the elderly (non-linear p = 0.0029). In receiver operating characteristic analysis, GNRI outperforms serum albumin or body mass index (BMI) alone in predicting OAB risk. The study revealed that inflammatory response mediates the relationship between GNRI and OAB, while cognitive function has a relatively weaker influence on the strength of the association between GNRI and OAB.ConclusionGNRI serves as a reliable predictive marker for OAB in the elderly population, demonstrating a nonlinear inverse correlation with OAB prevalence. Furthermore, this study elucidates the underlying inflammatory mechanisms that link GNRI to the development of OAB. |
| format | Article |
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| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-962fd34650b64736842573052eaf85cb2025-02-11T05:10:23ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.15375491537549Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional studyWei Zheng0Wei Zheng1Chuanzan Zhou2Jia Miao3Yunkai Yang4Xuanhan Hu5Heng Wang6Xinyu Zhang7Qi Zhang8Yifan Wang9Emergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaDepartment of Nursing, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaBackgroundThe prevalence of overactive bladder (OAB) is increasing in the elderly population and there is growing evidence that malnutrition affects the urinary system. Despite this, research on the relationship between nutritional factors and OAB remains limited.MethodsWe included 17,161 elderly individuals from the National Health and Nutrition Examination Survey conducted between 2005 and 2018. Overactive Bladder Symptom Scores (OABSS) were utilized to assess symptoms of OAB. A multifactorial logistic regression analysis was employed to evaluate the independent association between the Geriatric Nutritional Risk Index (GNRI) and the prevalence of OAB. Restricted cubic spline plots examined the potential non-linear relationship between GNRI and OAB. Influencing factors were assessed through subgroup analyses, while the predictive utility of GNRI was assessed with receiver operating characteristic (ROC) curves. The influence of inflammatory response and cognitive function on the interaction between GNRI and OAB was also examined by mediation analysis.ResultsGNRI in the OAB group was significantly lower than that in the non-OAB group. Multifactorial logistic regression analysis revealed that GNRI significantly predicts OAB (p < 0.05). The Restricted Cubic Spline (RCS) curve indicated a non-linear negative correlation between GNRI and the risk of OAB in the elderly (non-linear p = 0.0029). In receiver operating characteristic analysis, GNRI outperforms serum albumin or body mass index (BMI) alone in predicting OAB risk. The study revealed that inflammatory response mediates the relationship between GNRI and OAB, while cognitive function has a relatively weaker influence on the strength of the association between GNRI and OAB.ConclusionGNRI serves as a reliable predictive marker for OAB in the elderly population, demonstrating a nonlinear inverse correlation with OAB prevalence. Furthermore, this study elucidates the underlying inflammatory mechanisms that link GNRI to the development of OAB.https://www.frontiersin.org/articles/10.3389/fnut.2025.1537549/fullgeriatric nutritional risk indexoveractive bladderelderly populationnutritionNHANES database |
| spellingShingle | Wei Zheng Wei Zheng Chuanzan Zhou Jia Miao Yunkai Yang Xuanhan Hu Heng Wang Xinyu Zhang Qi Zhang Yifan Wang Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study Frontiers in Nutrition geriatric nutritional risk index overactive bladder elderly population nutrition NHANES database |
| title | Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study |
| title_full | Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study |
| title_fullStr | Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study |
| title_full_unstemmed | Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study |
| title_short | Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study |
| title_sort | association between geriatric nutritional risk index and overactive bladder in the elderly population a cross sectional study |
| topic | geriatric nutritional risk index overactive bladder elderly population nutrition NHANES database |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1537549/full |
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