Nanozyme based ultra-stretchable, low-hysteresis, and dual-mode antibacterial composite hydrogels for wound healing
Wound care always presents challenges as they are susceptible to bacterial infections and have mechanical compatibility issues with wound dressings, leading to a delayed recovery of the structure and functional integrity of skin tissue. Herein, an iron-based metal-organic framework loaded with gold...
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| author | Yanyan Li Weiqi Kang Jian Zhang Ping Shi Jianshu Li Yongping Lu |
| author_facet | Yanyan Li Weiqi Kang Jian Zhang Ping Shi Jianshu Li Yongping Lu |
| author_sort | Yanyan Li |
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| description | Wound care always presents challenges as they are susceptible to bacterial infections and have mechanical compatibility issues with wound dressings, leading to a delayed recovery of the structure and functional integrity of skin tissue. Herein, an iron-based metal-organic framework loaded with gold (Fe-MIL-88NH2-Au) nanozyme based composite hydrogel (HMAux) with excellent mechanical compatibility and dual-mode antibacterial properties was designed for wound care. To obtain HMAux, Fe-MIL-88NH2-Au nanozyme with photothermal properties and peroxidase-like and oxidase-like activities was prepared. Then it was introduced into the hydrogel system with a sea-island structure which was prepared via the copolymerization of acrylamide and acryloyl Pluronic F127 (PF127-DA) in the aqueous solution. Using dynamic micelles as the energy dissipation mechanism, double bonds and intermolecular interactions as two crosslinking methods in HMAux make it possess good stretchability (3244 %–4524 %), toughness (593.8 kJ/m3 to 421.5 kJ/m3), and low hysteresis (0.13–0.15). Furthermore, the synergistic photothermal and chemodynamic effects provide good antibacterial performance under mild conditions, with killing rates of approximately 95.02 % and 97.28 % for S. aureus and E. coli, respectively. In vivo experiments have proved that HMAux can effectively adapt to the contour of the wound and treat wound infections. |
| format | Article |
| id | doaj-art-968ee42b663a4741b4b2d3cf86eb0594 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
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| spelling | doaj-art-968ee42b663a4741b4b2d3cf86eb05942025-02-09T05:01:01ZengElsevierMaterials Today Bio2590-00642025-04-0131101547Nanozyme based ultra-stretchable, low-hysteresis, and dual-mode antibacterial composite hydrogels for wound healingYanyan Li0Weiqi Kang1Jian Zhang2Ping Shi3Jianshu Li4Yongping Lu5College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, PR ChinaScientific and Technological Innovation Center for Biomedical Materials and Clinical Research, Guangyuan Key Laboratory of Multifunctional Medical Hydrogel, Guangyuan Central Hospital, Guangyuan, 628000, PR ChinaCollege of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, PR ChinaScientific and Technological Innovation Center for Biomedical Materials and Clinical Research, Guangyuan Key Laboratory of Multifunctional Medical Hydrogel, Guangyuan Central Hospital, Guangyuan, 628000, PR China; Corresponding author.College of Polymer Science and Engineering, State Key Laboratory of Polymer, Sichuan University, Chengdu, 610041, PR China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; Corresponding author. College of Polymer Science and Engineering, State Key Laboratory of Polymer, Sichuan University, Chengdu, 610041, PR ChinaScientific and Technological Innovation Center for Biomedical Materials and Clinical Research, Guangyuan Key Laboratory of Multifunctional Medical Hydrogel, Guangyuan Central Hospital, Guangyuan, 628000, PR China; Corresponding author.Wound care always presents challenges as they are susceptible to bacterial infections and have mechanical compatibility issues with wound dressings, leading to a delayed recovery of the structure and functional integrity of skin tissue. Herein, an iron-based metal-organic framework loaded with gold (Fe-MIL-88NH2-Au) nanozyme based composite hydrogel (HMAux) with excellent mechanical compatibility and dual-mode antibacterial properties was designed for wound care. To obtain HMAux, Fe-MIL-88NH2-Au nanozyme with photothermal properties and peroxidase-like and oxidase-like activities was prepared. Then it was introduced into the hydrogel system with a sea-island structure which was prepared via the copolymerization of acrylamide and acryloyl Pluronic F127 (PF127-DA) in the aqueous solution. Using dynamic micelles as the energy dissipation mechanism, double bonds and intermolecular interactions as two crosslinking methods in HMAux make it possess good stretchability (3244 %–4524 %), toughness (593.8 kJ/m3 to 421.5 kJ/m3), and low hysteresis (0.13–0.15). Furthermore, the synergistic photothermal and chemodynamic effects provide good antibacterial performance under mild conditions, with killing rates of approximately 95.02 % and 97.28 % for S. aureus and E. coli, respectively. In vivo experiments have proved that HMAux can effectively adapt to the contour of the wound and treat wound infections.http://www.sciencedirect.com/science/article/pii/S259000642500105XDynamic micelleLow-hysteresisPeroxidase and oxidase mimicsPhotothermal effectDual-mode antibacterial |
| spellingShingle | Yanyan Li Weiqi Kang Jian Zhang Ping Shi Jianshu Li Yongping Lu Nanozyme based ultra-stretchable, low-hysteresis, and dual-mode antibacterial composite hydrogels for wound healing Materials Today Bio Dynamic micelle Low-hysteresis Peroxidase and oxidase mimics Photothermal effect Dual-mode antibacterial |
| title | Nanozyme based ultra-stretchable, low-hysteresis, and dual-mode antibacterial composite hydrogels for wound healing |
| title_full | Nanozyme based ultra-stretchable, low-hysteresis, and dual-mode antibacterial composite hydrogels for wound healing |
| title_fullStr | Nanozyme based ultra-stretchable, low-hysteresis, and dual-mode antibacterial composite hydrogels for wound healing |
| title_full_unstemmed | Nanozyme based ultra-stretchable, low-hysteresis, and dual-mode antibacterial composite hydrogels for wound healing |
| title_short | Nanozyme based ultra-stretchable, low-hysteresis, and dual-mode antibacterial composite hydrogels for wound healing |
| title_sort | nanozyme based ultra stretchable low hysteresis and dual mode antibacterial composite hydrogels for wound healing |
| topic | Dynamic micelle Low-hysteresis Peroxidase and oxidase mimics Photothermal effect Dual-mode antibacterial |
| url | http://www.sciencedirect.com/science/article/pii/S259000642500105X |
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