Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality
Aging populations are susceptible to climate change due to physiological factors and comorbidities. Most relevant studies reported the effect of temperature on cardiovascular disease (CVD)-related mortality in aging populations. However, the combined effects of temperature and humidity on CVD-relate...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132500082X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856921469255680 |
|---|---|
| author | Yalan Wu Xiangrong Feng Jinmei Li Mengjun Li Yao Wang Weihui Lu Huanhuan Luo |
| author_facet | Yalan Wu Xiangrong Feng Jinmei Li Mengjun Li Yao Wang Weihui Lu Huanhuan Luo |
| author_sort | Yalan Wu |
| collection | DOAJ |
| description | Aging populations are susceptible to climate change due to physiological factors and comorbidities. Most relevant studies reported the effect of temperature on cardiovascular disease (CVD)-related mortality in aging populations. However, the combined effects of temperature and humidity on CVD-related mortality remain unclear. Here we used the Global Burden of Disease (GBD) database to analyze CVD burden and its impact on the incidence of CVD in individuals exposed to high-temperature and high-humidity (HTH) environments. The prospective China Health and Retirement Longitudinal Study (CHARLS) cohort was used to further analyze the relationship between exposure to HTH environments and CVD mortality in middle-aged and elderly individuals. We found significant positive correlations between the estimated annual percentage change of CVD and age-standardized rate, wet bulb globe temperature, and Humidex worldwide. In the CHARLS, a higher CVD mortality rate was significantly associated with exposure to HTH environments (P < 0.01). Long-term HTH environment exposure increased the risk of an abnormal low-density lipoprotein cholesterol (LDL-C) level (hazard ratio [HR], 1.30–2.44) and abnormal total cholesterol (TC) level (HR, 1.21–2.13), but the impact on high-density lipoprotein cholesterol (HDL-C) level was unclear. The mortality risks of long-term exposure to HTH environments were increased for middle-aged and elderly individuals with abnormal LDL-C (HR = 0.84–3.57) and TC (HR = 0.78–2.41) levels. These findings suggest that exacerbated dyslipidemia caused by long-term HTH environment exposure may be a key risk factor for CVD-related mortality in middle-aged and elderly individuals and suggest research directions into the effects of HTH environments on human health. |
| format | Article |
| id | doaj-art-97d797331d964c5ea90d2fec9f774611 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-97d797331d964c5ea90d2fec9f7746112025-02-12T05:30:10ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117746Exposure to high-temperature and high-humidity environments associated with cardiovascular mortalityYalan Wu0Xiangrong Feng1Jinmei Li2Mengjun Li3Yao Wang4Weihui Lu5Huanhuan Luo6School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, School of Medicine, Shenzhen University, Shenzhen 518060, ChinaSchool of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaZhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, Zhongshan 528400, China; Corresponding author.Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; Corresponding author at: Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, China.Chinese Medicine Guangdong Laboratory, Hengqin 519031, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; Corresponding author at: Chinese Medicine Guangdong Laboratory, Hengqin 519031, China.Aging populations are susceptible to climate change due to physiological factors and comorbidities. Most relevant studies reported the effect of temperature on cardiovascular disease (CVD)-related mortality in aging populations. However, the combined effects of temperature and humidity on CVD-related mortality remain unclear. Here we used the Global Burden of Disease (GBD) database to analyze CVD burden and its impact on the incidence of CVD in individuals exposed to high-temperature and high-humidity (HTH) environments. The prospective China Health and Retirement Longitudinal Study (CHARLS) cohort was used to further analyze the relationship between exposure to HTH environments and CVD mortality in middle-aged and elderly individuals. We found significant positive correlations between the estimated annual percentage change of CVD and age-standardized rate, wet bulb globe temperature, and Humidex worldwide. In the CHARLS, a higher CVD mortality rate was significantly associated with exposure to HTH environments (P < 0.01). Long-term HTH environment exposure increased the risk of an abnormal low-density lipoprotein cholesterol (LDL-C) level (hazard ratio [HR], 1.30–2.44) and abnormal total cholesterol (TC) level (HR, 1.21–2.13), but the impact on high-density lipoprotein cholesterol (HDL-C) level was unclear. The mortality risks of long-term exposure to HTH environments were increased for middle-aged and elderly individuals with abnormal LDL-C (HR = 0.84–3.57) and TC (HR = 0.78–2.41) levels. These findings suggest that exacerbated dyslipidemia caused by long-term HTH environment exposure may be a key risk factor for CVD-related mortality in middle-aged and elderly individuals and suggest research directions into the effects of HTH environments on human health.http://www.sciencedirect.com/science/article/pii/S014765132500082XHigh-temperature and high-humidity environmentsCardiovascular diseaseMiddle-aged and elderly individualsAbnormal LDL-CMortality |
| spellingShingle | Yalan Wu Xiangrong Feng Jinmei Li Mengjun Li Yao Wang Weihui Lu Huanhuan Luo Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality Ecotoxicology and Environmental Safety High-temperature and high-humidity environments Cardiovascular disease Middle-aged and elderly individuals Abnormal LDL-C Mortality |
| title | Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality |
| title_full | Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality |
| title_fullStr | Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality |
| title_full_unstemmed | Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality |
| title_short | Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality |
| title_sort | exposure to high temperature and high humidity environments associated with cardiovascular mortality |
| topic | High-temperature and high-humidity environments Cardiovascular disease Middle-aged and elderly individuals Abnormal LDL-C Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S014765132500082X |
| work_keys_str_mv | AT yalanwu exposuretohightemperatureandhighhumidityenvironmentsassociatedwithcardiovascularmortality AT xiangrongfeng exposuretohightemperatureandhighhumidityenvironmentsassociatedwithcardiovascularmortality AT jinmeili exposuretohightemperatureandhighhumidityenvironmentsassociatedwithcardiovascularmortality AT mengjunli exposuretohightemperatureandhighhumidityenvironmentsassociatedwithcardiovascularmortality AT yaowang exposuretohightemperatureandhighhumidityenvironmentsassociatedwithcardiovascularmortality AT weihuilu exposuretohightemperatureandhighhumidityenvironmentsassociatedwithcardiovascularmortality AT huanhuanluo exposuretohightemperatureandhighhumidityenvironmentsassociatedwithcardiovascularmortality |