Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives
Neurological diseases have important effects on morbidity and mortality rates. Natural products offer various health benefits, and Dracocephalum species, belonging to the Lamiaceae family, have been traditionally used for several therapeutic values. The genus Dracocephalum and its metabolites have...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2024-12-01
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| Series: | Traditional and Integrative Medicine |
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| Online Access: | https://jtim.tums.ac.ir/index.php/jtim/article/view/1433 |
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| author | Marjan Talebi Alireza Ghassempour Afsoon Feizi Seyed Abdulmajid Ayatollahi Mehrdad Faizi |
| author_facet | Marjan Talebi Alireza Ghassempour Afsoon Feizi Seyed Abdulmajid Ayatollahi Mehrdad Faizi |
| author_sort | Marjan Talebi |
| collection | DOAJ |
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Neurological diseases have important effects on morbidity and mortality rates. Natural products offer various health benefits, and Dracocephalum species, belonging to the Lamiaceae family, have been traditionally used for several therapeutic values. The genus Dracocephalum and its metabolites have demonstrated numerous pharmacological activities such as antioxidative, anti-inflammatory, antiviral, antiparasitic, antibacterial, antifungal, nephroprotective, hepatoprotective, neuroprotective, gastroprotective, cardioprotective, antiapoptotic, and anticancer effects. Dracocephalum spp. contain phytosterols, polysaccharides, coumarins, alkaloids, phenolic acids, flavonoids, and terpenes. This review explores the potential neuroprotective effects of Dracocephalum spp. by evaluating the mechanisms and signaling pathways involved. The role of the genus Dracocephalum was investigated in relation to various neurological conditions such as Alzheimer's disease, insomnia, Parkinson's disease, vascular dementia, cerebral ischemia, pain, depression, and glioblastoma. These findings suggest that Dracocephalum spp. and their phytochemicals have neuroprotective effects by targeting the regulation of various pathways. Therefore, clinical trials should be performed to confirm the in vitro and animal findings.
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| format | Article |
| id | doaj-art-9886d1137f0845f28b2fd5aff266fb1b |
| institution | Kabale University |
| issn | 2476-5104 2476-5112 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Traditional and Integrative Medicine |
| spelling | doaj-art-9886d1137f0845f28b2fd5aff266fb1b2025-02-09T09:11:23ZengTehran University of Medical SciencesTraditional and Integrative Medicine2476-51042476-51122024-12-019410.18502/tim.v9i4.17479Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic PerspectivesMarjan Talebi0Alireza Ghassempour1Afsoon Feizi2Seyed Abdulmajid Ayatollahi3Mehrdad Faizi4Student Research Committee, Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranMedicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, IranFaculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, IranPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Neurological diseases have important effects on morbidity and mortality rates. Natural products offer various health benefits, and Dracocephalum species, belonging to the Lamiaceae family, have been traditionally used for several therapeutic values. The genus Dracocephalum and its metabolites have demonstrated numerous pharmacological activities such as antioxidative, anti-inflammatory, antiviral, antiparasitic, antibacterial, antifungal, nephroprotective, hepatoprotective, neuroprotective, gastroprotective, cardioprotective, antiapoptotic, and anticancer effects. Dracocephalum spp. contain phytosterols, polysaccharides, coumarins, alkaloids, phenolic acids, flavonoids, and terpenes. This review explores the potential neuroprotective effects of Dracocephalum spp. by evaluating the mechanisms and signaling pathways involved. The role of the genus Dracocephalum was investigated in relation to various neurological conditions such as Alzheimer's disease, insomnia, Parkinson's disease, vascular dementia, cerebral ischemia, pain, depression, and glioblastoma. These findings suggest that Dracocephalum spp. and their phytochemicals have neuroprotective effects by targeting the regulation of various pathways. Therefore, clinical trials should be performed to confirm the in vitro and animal findings. https://jtim.tums.ac.ir/index.php/jtim/article/view/1433DracocephalumFlavonoidsLamiaceaeNeurological disordersNeurodegenerative diseasesTraditional medicine |
| spellingShingle | Marjan Talebi Alireza Ghassempour Afsoon Feizi Seyed Abdulmajid Ayatollahi Mehrdad Faizi Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives Traditional and Integrative Medicine Dracocephalum Flavonoids Lamiaceae Neurological disorders Neurodegenerative diseases Traditional medicine |
| title | Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives |
| title_full | Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives |
| title_fullStr | Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives |
| title_full_unstemmed | Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives |
| title_short | Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives |
| title_sort | promising neuroprotective effects of dracocephalum species mechanistic perspectives |
| topic | Dracocephalum Flavonoids Lamiaceae Neurological disorders Neurodegenerative diseases Traditional medicine |
| url | https://jtim.tums.ac.ir/index.php/jtim/article/view/1433 |
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