Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary
Intestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of niche factors required to maintain intestinal...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X2400198X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206889159327744 |
|---|---|
| author | Michaela Quintero Linda C. Samuelson |
| author_facet | Michaela Quintero Linda C. Samuelson |
| author_sort | Michaela Quintero |
| collection | DOAJ |
| description | Intestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of niche factors required to maintain intestinal stem cells and to direct their proliferation and differentiation. Among the various mature intestinal epithelial cell types, Paneth cells are unique in their location in the stem cell zone, directly adjacent to intestinal stem cells. Although Paneth cells were first described as an epithelial cell component of the innate immune system due to their expression of anti-microbial peptides, they have been proposed to be niche cells due to their close proximity to intestinal stem cells and expression of niche factors. However, function as a niche cell has been debated since mice lacking Paneth cells retain functional stem cells that continue to replenish the intestinal epithelium. In this review, we summarize the intestinal stem cell niche, including the Notch, Wnt, growth factor, mechanical, and metabolic niche, and discuss how Paneth cells might contribute to these various components. We also present a nuanced view of the Paneth cell as a niche cell. Although not required, Paneth cells enhance stem cell function, particularly during intestinal development and regeneration. Furthermore, we suggest that Paneth cell loss induces intestinal stem cell remodeling to adjust their niche demands. |
| format | Article |
| id | doaj-art-9af862d149684910a7c157a2cfc8a801 |
| institution | Kabale University |
| issn | 2352-345X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj-art-9af862d149684910a7c157a2cfc8a8012025-02-07T04:47:46ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2025-01-01194101443Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummaryMichaela Quintero0Linda C. Samuelson1Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MichiganDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; Correspondence Address correspondence to: Linda C. Samuelson, PhD, 109 Zina Pitcher Place, 2041 BSRB, The University of Michigan, Ann Arbor, Michigan 48109; tel: (734) 764-9448.Intestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of niche factors required to maintain intestinal stem cells and to direct their proliferation and differentiation. Among the various mature intestinal epithelial cell types, Paneth cells are unique in their location in the stem cell zone, directly adjacent to intestinal stem cells. Although Paneth cells were first described as an epithelial cell component of the innate immune system due to their expression of anti-microbial peptides, they have been proposed to be niche cells due to their close proximity to intestinal stem cells and expression of niche factors. However, function as a niche cell has been debated since mice lacking Paneth cells retain functional stem cells that continue to replenish the intestinal epithelium. In this review, we summarize the intestinal stem cell niche, including the Notch, Wnt, growth factor, mechanical, and metabolic niche, and discuss how Paneth cells might contribute to these various components. We also present a nuanced view of the Paneth cell as a niche cell. Although not required, Paneth cells enhance stem cell function, particularly during intestinal development and regeneration. Furthermore, we suggest that Paneth cell loss induces intestinal stem cell remodeling to adjust their niche demands.http://www.sciencedirect.com/science/article/pii/S2352345X2400198XCellular RemodelingIntestinal CryptNotch SignalingTissue RegenerationWNT Signaling |
| spellingShingle | Michaela Quintero Linda C. Samuelson Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary Cellular and Molecular Gastroenterology and Hepatology Cellular Remodeling Intestinal Crypt Notch Signaling Tissue Regeneration WNT Signaling |
| title | Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary |
| title_full | Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary |
| title_fullStr | Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary |
| title_full_unstemmed | Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary |
| title_short | Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary |
| title_sort | paneth cells dispensable yet irreplaceable for the intestinal stem cell nichesummary |
| topic | Cellular Remodeling Intestinal Crypt Notch Signaling Tissue Regeneration WNT Signaling |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X2400198X |
| work_keys_str_mv | AT michaelaquintero panethcellsdispensableyetirreplaceablefortheintestinalstemcellnichesummary AT lindacsamuelson panethcellsdispensableyetirreplaceablefortheintestinalstemcellnichesummary |