Organoid models: applications and research advances in colorectal cancer
This review summarizes the applications and research progress of organoid models in colorectal cancer research. First, the high incidence and mortality rates of colorectal cancer are introduced, emphasizing the importance of organoids as a research model. Second, this review provides a detailed intr...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1432506/full |
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| _version_ | 1825206807370399744 |
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| author | Yijie Wu Yijie Wu Yu Sha Xingpo Guo Ling Gao Jian Huang Song-Bai Liu Song-Bai Liu |
| author_facet | Yijie Wu Yijie Wu Yu Sha Xingpo Guo Ling Gao Jian Huang Song-Bai Liu Song-Bai Liu |
| author_sort | Yijie Wu |
| collection | DOAJ |
| description | This review summarizes the applications and research progress of organoid models in colorectal cancer research. First, the high incidence and mortality rates of colorectal cancer are introduced, emphasizing the importance of organoids as a research model. Second, this review provides a detailed introduction to the concept, biological properties, and applications of organoids, including their strengths in mimicking the structural and functional aspects of organs. This article further analyzes the applications of adult stem cell-derived and pluripotent stem cell-derived organoids in colorectal cancer research and discusses advancements in organoids for basic research, drug research and development, personalized treatment evaluation and prediction, and regenerative medicine. Finally, this review summarizes the prospects for applying organoid technology in colorectal cancer research, emphasizing its significant value in improving patient survival rates. In conclusion, this review systematically explains the applications of organoids in colorectal cancer research, highlighting their tremendous potential and promising prospects in basic research, drug research and development, personalized treatment evaluation and prediction, and regenerative medicine. |
| format | Article |
| id | doaj-art-9b18f2b7a98e419dbdf842a3a7233506 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-9b18f2b7a98e419dbdf842a3a72335062025-02-07T05:10:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14325061432506Organoid models: applications and research advances in colorectal cancerYijie Wu0Yijie Wu1Yu Sha2Xingpo Guo3Ling Gao4Jian Huang5Song-Bai Liu6Song-Bai Liu7College of Life Science, North China University of Science and Technology, Tangshan, ChinaJiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology, Suzhou Vocational Health College, Suzhou, ChinaJiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology, Suzhou Vocational Health College, Suzhou, ChinaDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, ChinaJiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology, Suzhou Vocational Health College, Suzhou, ChinaCollege of Life Science, North China University of Science and Technology, Tangshan, ChinaJiangsu Province Engineering Research Center of Molecular Target Therapy and Companion Diagnostics in Oncology, Suzhou Vocational Health College, Suzhou, ChinaThis review summarizes the applications and research progress of organoid models in colorectal cancer research. First, the high incidence and mortality rates of colorectal cancer are introduced, emphasizing the importance of organoids as a research model. Second, this review provides a detailed introduction to the concept, biological properties, and applications of organoids, including their strengths in mimicking the structural and functional aspects of organs. This article further analyzes the applications of adult stem cell-derived and pluripotent stem cell-derived organoids in colorectal cancer research and discusses advancements in organoids for basic research, drug research and development, personalized treatment evaluation and prediction, and regenerative medicine. Finally, this review summarizes the prospects for applying organoid technology in colorectal cancer research, emphasizing its significant value in improving patient survival rates. In conclusion, this review systematically explains the applications of organoids in colorectal cancer research, highlighting their tremendous potential and promising prospects in basic research, drug research and development, personalized treatment evaluation and prediction, and regenerative medicine.https://www.frontiersin.org/articles/10.3389/fonc.2025.1432506/fullorganoidscolorectal cancerresearch advancescancerapplications |
| spellingShingle | Yijie Wu Yijie Wu Yu Sha Xingpo Guo Ling Gao Jian Huang Song-Bai Liu Song-Bai Liu Organoid models: applications and research advances in colorectal cancer Frontiers in Oncology organoids colorectal cancer research advances cancer applications |
| title | Organoid models: applications and research advances in colorectal cancer |
| title_full | Organoid models: applications and research advances in colorectal cancer |
| title_fullStr | Organoid models: applications and research advances in colorectal cancer |
| title_full_unstemmed | Organoid models: applications and research advances in colorectal cancer |
| title_short | Organoid models: applications and research advances in colorectal cancer |
| title_sort | organoid models applications and research advances in colorectal cancer |
| topic | organoids colorectal cancer research advances cancer applications |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1432506/full |
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