Induced-volatolomics, a new research field in chemical biology
Progresses in chemical biology have substantially deepened our understanding of biological pathways related to disease outcomes. Numerous optical probes activatable by disease-relevant enzymes have been designed and have shown great value for imaging crucial biochemical transformations specific to p...
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| Format: | Article |
| Language: | English |
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Académie des sciences
2024-04-01
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| Series: | Comptes Rendus. Chimie |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.252/ |
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| author | Blochouse, Estelle Eid, Rony Cannoni, Elsa Châtre, Rémi Geffroy, Claude Opalinski, Isabelle Papot, Sébastien Poinot, Pauline |
| author_facet | Blochouse, Estelle Eid, Rony Cannoni, Elsa Châtre, Rémi Geffroy, Claude Opalinski, Isabelle Papot, Sébastien Poinot, Pauline |
| author_sort | Blochouse, Estelle |
| collection | DOAJ |
| description | Progresses in chemical biology have substantially deepened our understanding of biological pathways related to disease outcomes. Numerous optical probes activatable by disease-relevant enzymes have been designed and have shown great value for imaging crucial biochemical transformations specific to pathological processes. In comparison to their “always-on” counterparts, such stimuli-responsive probes stand out as promising candidates for exploring biological processes because of their high sensitivity, ingenious spatiotemporal resolution, ease of operation, and real-time and in situ imaging capacity. However, these imaging tools meet several bottlenecks related to either stability, background noise, limited penetration depth or systemic toxicity, pharmacokinetics, tissue distribution, and renal clearance.In parallel, novel volatile organic compound (VOC)-based probes have been proposed under the emerging paradigm of induced-volatolomics. These probes are converted into exogenous VOCs in response to pathogen or eukaryote specific enzymatic stimuli. Once activated, VOC-based probes release volatile tracers that inform the biochemical processes arising in cells, liquid and solid biopsies, and even in entire organisms. After a brief presentation of recent developments in the field of induced-volatolomics, we discuss possible improvements of this new modality for the exploration of biological systems. |
| format | Article |
| id | doaj-art-9bf8641ebf04447ca61d6b0af80e0399 |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-9bf8641ebf04447ca61d6b0af80e03992025-02-07T13:38:54ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432024-04-0126S39310310.5802/crchim.25210.5802/crchim.252Induced-volatolomics, a new research field in chemical biologyBlochouse, Estelle0https://orcid.org/0009-0002-1491-5722Eid, Rony1Cannoni, Elsa2Châtre, Rémi3Geffroy, Claude4https://orcid.org/0000-0002-2731-9658Opalinski, Isabelle5https://orcid.org/0000-0003-0760-5056Papot, Sébastien6https://orcid.org/0000-0001-5253-1979Poinot, Pauline7https://orcid.org/0000-0002-7927-1887University of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Equipe Labellisée Ligue Contre le Cancer, 4 rue Michel-Brunet, TSA 51106, 86073 Poitiers cedex 9, FranceUniversity of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Equipe Labellisée Ligue Contre le Cancer, 4 rue Michel-Brunet, TSA 51106, 86073 Poitiers cedex 9, FranceUniversity of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Equipe Labellisée Ligue Contre le Cancer, 4 rue Michel-Brunet, TSA 51106, 86073 Poitiers cedex 9, FranceUniversity of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Equipe Labellisée Ligue Contre le Cancer, 4 rue Michel-Brunet, TSA 51106, 86073 Poitiers cedex 9, FranceUniversity of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Equipe Labellisée Ligue Contre le Cancer, 4 rue Michel-Brunet, TSA 51106, 86073 Poitiers cedex 9, FranceUniversity of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Equipe Labellisée Ligue Contre le Cancer, 4 rue Michel-Brunet, TSA 51106, 86073 Poitiers cedex 9, FranceSeekyo SA, 2 avenue Galilée, BP 30153, 86961 Futuroscope, France; University of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Equipe Labellisée Ligue Contre le Cancer, 4 rue Michel-Brunet, TSA 51106, 86073 Poitiers cedex 9, FranceUniversity of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Equipe Labellisée Ligue Contre le Cancer, 4 rue Michel-Brunet, TSA 51106, 86073 Poitiers cedex 9, FranceProgresses in chemical biology have substantially deepened our understanding of biological pathways related to disease outcomes. Numerous optical probes activatable by disease-relevant enzymes have been designed and have shown great value for imaging crucial biochemical transformations specific to pathological processes. In comparison to their “always-on” counterparts, such stimuli-responsive probes stand out as promising candidates for exploring biological processes because of their high sensitivity, ingenious spatiotemporal resolution, ease of operation, and real-time and in situ imaging capacity. However, these imaging tools meet several bottlenecks related to either stability, background noise, limited penetration depth or systemic toxicity, pharmacokinetics, tissue distribution, and renal clearance.In parallel, novel volatile organic compound (VOC)-based probes have been proposed under the emerging paradigm of induced-volatolomics. These probes are converted into exogenous VOCs in response to pathogen or eukaryote specific enzymatic stimuli. Once activated, VOC-based probes release volatile tracers that inform the biochemical processes arising in cells, liquid and solid biopsies, and even in entire organisms. After a brief presentation of recent developments in the field of induced-volatolomics, we discuss possible improvements of this new modality for the exploration of biological systems.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.252/VOCInduced-volatolomicsEnzyme-responsive probesDiagnosisChemical biology |
| spellingShingle | Blochouse, Estelle Eid, Rony Cannoni, Elsa Châtre, Rémi Geffroy, Claude Opalinski, Isabelle Papot, Sébastien Poinot, Pauline Induced-volatolomics, a new research field in chemical biology Comptes Rendus. Chimie VOC Induced-volatolomics Enzyme-responsive probes Diagnosis Chemical biology |
| title | Induced-volatolomics, a new research field in chemical biology |
| title_full | Induced-volatolomics, a new research field in chemical biology |
| title_fullStr | Induced-volatolomics, a new research field in chemical biology |
| title_full_unstemmed | Induced-volatolomics, a new research field in chemical biology |
| title_short | Induced-volatolomics, a new research field in chemical biology |
| title_sort | induced volatolomics a new research field in chemical biology |
| topic | VOC Induced-volatolomics Enzyme-responsive probes Diagnosis Chemical biology |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.252/ |
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