Synchronous multiple myeloma and lung adenocarcinoma: A clinical series
Background: Multiple myeloma (MM) is characterised by an increased number of monoclonal immunoglobulin-producing plasma cells that malignantly grow in the bone marrow. Lung cancer is one of the most common malignancies and at the advanced stage may become metastatic to the bone. Rarely, MM and lung...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_530_22 |
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| _version_ | 1825205459382960128 |
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| author | Fang Ye Huan Wang Ningning Li Aijun Liu Wenming Chen |
| author_facet | Fang Ye Huan Wang Ningning Li Aijun Liu Wenming Chen |
| author_sort | Fang Ye |
| collection | DOAJ |
| description | Background:
Multiple myeloma (MM) is characterised by an increased number of monoclonal immunoglobulin-producing plasma cells that malignantly grow in the bone marrow. Lung cancer is one of the most common malignancies and at the advanced stage may become metastatic to the bone. Rarely, MM and lung cancer are synchronously present in the same patient.
Materials and Methods,
Results:
In this report, we describe five cases of MM synchronous with lung adenocarcinoma including λ light chain in three cases and ϰ light chain in two cases. Two patients achieved complete remission, and no progression was seen in two patients.
Conclusion:
In conclusion, synchronous MM and lung adenocarcinoma are clinically rare, and diagnosis should be made scrupulously based on morphology, immunology, cytogenetics, molecular biology and biopsy pathology. |
| format | Article |
| id | doaj-art-9e26cb9cf7d2485db8e8ab10bfac603c |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-9e26cb9cf7d2485db8e8ab10bfac603c2025-02-07T13:58:37ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-04-0167239039510.4103/ijpm.ijpm_530_22Synchronous multiple myeloma and lung adenocarcinoma: A clinical seriesFang YeHuan WangNingning LiAijun LiuWenming ChenBackground: Multiple myeloma (MM) is characterised by an increased number of monoclonal immunoglobulin-producing plasma cells that malignantly grow in the bone marrow. Lung cancer is one of the most common malignancies and at the advanced stage may become metastatic to the bone. Rarely, MM and lung cancer are synchronously present in the same patient. Materials and Methods, Results: In this report, we describe five cases of MM synchronous with lung adenocarcinoma including λ light chain in three cases and ϰ light chain in two cases. Two patients achieved complete remission, and no progression was seen in two patients. Conclusion: In conclusion, synchronous MM and lung adenocarcinoma are clinically rare, and diagnosis should be made scrupulously based on morphology, immunology, cytogenetics, molecular biology and biopsy pathology.https://journals.lww.com/10.4103/ijpm.ijpm_530_22lung adenocarcinomalytic bone lesionsmultiple myelomasecond tumourssynchronous tumours |
| spellingShingle | Fang Ye Huan Wang Ningning Li Aijun Liu Wenming Chen Synchronous multiple myeloma and lung adenocarcinoma: A clinical series Indian Journal of Pathology and Microbiology lung adenocarcinoma lytic bone lesions multiple myeloma second tumours synchronous tumours |
| title | Synchronous multiple myeloma and lung adenocarcinoma: A clinical series |
| title_full | Synchronous multiple myeloma and lung adenocarcinoma: A clinical series |
| title_fullStr | Synchronous multiple myeloma and lung adenocarcinoma: A clinical series |
| title_full_unstemmed | Synchronous multiple myeloma and lung adenocarcinoma: A clinical series |
| title_short | Synchronous multiple myeloma and lung adenocarcinoma: A clinical series |
| title_sort | synchronous multiple myeloma and lung adenocarcinoma a clinical series |
| topic | lung adenocarcinoma lytic bone lesions multiple myeloma second tumours synchronous tumours |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_530_22 |
| work_keys_str_mv | AT fangye synchronousmultiplemyelomaandlungadenocarcinomaaclinicalseries AT huanwang synchronousmultiplemyelomaandlungadenocarcinomaaclinicalseries AT ningningli synchronousmultiplemyelomaandlungadenocarcinomaaclinicalseries AT aijunliu synchronousmultiplemyelomaandlungadenocarcinomaaclinicalseries AT wenmingchen synchronousmultiplemyelomaandlungadenocarcinomaaclinicalseries |