Daropeptide natural products
Cyclophane-containing peptides comprise an important group of macrocyclic peptides with unique structural properties and pharmaceutical relevance. Darobactin A is a ribosomally synthesized and post-translationally modified peptide (RiPP) antibiotic, which features an unusual biscyclophane moiety for...
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| Format: | Article |
| Language: | English |
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Open Exploration
2024-04-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100842/100842.pdf |
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| _version_ | 1825199592766963712 |
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| author | Suze Ma Sijia Guo Wei Ding Qi Zhang |
| author_facet | Suze Ma Sijia Guo Wei Ding Qi Zhang |
| author_sort | Suze Ma |
| collection | DOAJ |
| description | Cyclophane-containing peptides comprise an important group of macrocyclic peptides with unique structural properties and pharmaceutical relevance. Darobactin A is a ribosomally synthesized and post-translationally modified peptide (RiPP) antibiotic, which features an unusual biscyclophane moiety formed via the class-defining ether crosslink in addition to a carbon-carbon (C-C) crosslink. Because darobactin-like peptides (daropeptides) are widespread in nature, further exploration of these emerging RiPP natural products featuring ether crosslinked cyclophane could facilitate the discovery and development of new bioactive peptides. This perspective provides updated insights into the biosynthesis and classification of daropeptides, highlighting the potential to manipulate daropeptide maturases to access novel bioactive peptide cyclophanes. |
| format | Article |
| id | doaj-art-9e4e772ef1874fb68cdc5824bb096a7a |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-9e4e772ef1874fb68cdc5824bb096a7a2025-02-08T03:41:44ZengOpen ExplorationExploration of Drug Science2836-76772024-04-012219020210.37349/eds.2024.00042Daropeptide natural productsSuze Ma0https://orcid.org/0000-0001-8030-2401Sijia Guo1https://orcid.org/0009-0005-5073-2626Wei Ding2Qi Zhang3https://orcid.org/0000-0002-8135-2221State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; Department of Chemistry, Fudan University, Shanghai 200433, ChinaState Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, ChinaDepartment of Chemistry, Fudan University, Shanghai 200433, ChinaCyclophane-containing peptides comprise an important group of macrocyclic peptides with unique structural properties and pharmaceutical relevance. Darobactin A is a ribosomally synthesized and post-translationally modified peptide (RiPP) antibiotic, which features an unusual biscyclophane moiety formed via the class-defining ether crosslink in addition to a carbon-carbon (C-C) crosslink. Because darobactin-like peptides (daropeptides) are widespread in nature, further exploration of these emerging RiPP natural products featuring ether crosslinked cyclophane could facilitate the discovery and development of new bioactive peptides. This perspective provides updated insights into the biosynthesis and classification of daropeptides, highlighting the potential to manipulate daropeptide maturases to access novel bioactive peptide cyclophanes.https://www.explorationpub.com/uploads/Article/A100842/100842.pdfbiosynthesisradical s-adenosylmethionineantibioticcyclophane |
| spellingShingle | Suze Ma Sijia Guo Wei Ding Qi Zhang Daropeptide natural products Exploration of Drug Science biosynthesis radical s-adenosylmethionine antibiotic cyclophane |
| title | Daropeptide natural products |
| title_full | Daropeptide natural products |
| title_fullStr | Daropeptide natural products |
| title_full_unstemmed | Daropeptide natural products |
| title_short | Daropeptide natural products |
| title_sort | daropeptide natural products |
| topic | biosynthesis radical s-adenosylmethionine antibiotic cyclophane |
| url | https://www.explorationpub.com/uploads/Article/A100842/100842.pdf |
| work_keys_str_mv | AT suzema daropeptidenaturalproducts AT sijiaguo daropeptidenaturalproducts AT weiding daropeptidenaturalproducts AT qizhang daropeptidenaturalproducts |